Maternal perinatal undernutrition attenuates T-cell function in adult male rat offspring

Cellular Physiology and Biochemistry

Volumn 27, Issue 3-4, 2011, Pages 381-390

  Badr, Gamal ^a,b   Mohany, Mohamed ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Assiut University   (Egypt)

Author keywords

Cytokines; Maternal malnutrition; Offspring; Polyfunction; T cells

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 7; PROTEIN KINASE B; STAT5 PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELIVERY; DIET RESTRICTION; FEMALE; GESTATIONAL AGE; LACTATION; MALE; MALNUTRITION; MATERNAL NUTRITION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN PHOSPHORYLATION; RAT; T LYMPHOCYTE; WEANING;

RATTUS;

EID: 79953794354     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000327964     Document Type: Article

References (31)

1. Barker DJ: The developmental origins of chronic adult disease. Acta Paediatr Suppl 2004;93:26-33.
2. Collins S: Treating severe acute malnutrition seriously. Arch Dis Child 2007;92:453-461.
3. Woodward B: Depressed adaptive immune competence in acute proteinenergy malnutrition: a regulated pathophysiology controlled by endocrine hormones and cytokines; in Chandra RK (ed): Nutrition and Immunology in the 21st century. TSAR Health, Gurgaon/Toronto, 2004, pp 23-38.
4. Schaible UE, Kaufmann SHE: Malnutrition and infection: complex mechanisms and global impacts. PLoS Med 2007;4:806-812.
5. Woodward B: The effect of protein-energy malnutrition on immune competence; in Suskind RM, Tontisirin K (eds): Nutrition, Immunity, and Infection in Infants and Children. Vevey/Lippincott Williams & Wilkins, Philadelphia: 2001, pp 89-120.
6. Ing R, Su Z, Scott ME, Koski KG: Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice. Proc Natl Acad Sci USA. 2000;97:7078-7083. (Pubitemid 30431420)
7. Heird WC: in Nelson Behrman RE, Kliegman RM, Jenson FB (eds); Food Insecurity, Hunger and Undernutrition; 17th ed., Chapter 42, WB Saunders Company Philadelphia, 2004, pp 167-173.
8. Dai G, McMurray DN: Altered cytokine production and impaired antimycobacterial immunity in protein-malnourished guinea pigs. Infect Immun 1998;66:3562-3568. (Pubitemid 28347809)
9. Badr G, Sayed D, Alhazzaa I, Elsayh K, Ahmed E, Alwasel S: T lymphocytes from malnourished infants are short-lived and dysfunctional cells. Immunobiology 2011;216:309-315.
10. Rodríguez L, González C, Flores L, Graniel J, Ortiz R: Assessment by flow cytometry of cytokine production in malnourished children. Clin Diagn Lab Immunol 2005;12:502-507. (Pubitemid 41175317)
11. González-Martínez H, Rodríguez L, Nájera O, Cruz D, Miliar A, Domínguez A, Sánchez F, Graniel J, González-Torres MC: Expression of cytokine mRNA in lymphocytes of malnourished children. J Clin Immunol 2008;28:593-599.
12. Fock RA, Vinolo MA, de Moura Sá Rocha V, de Sá Rocha LC, Borelli P: Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in mice. Cytokine 2007;40:105-114. (Pubitemid 350180527)
13. Kisseleva T, Bhattacharya S, Braunstein J, Schindler W: Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002;285:1-24. (Pubitemid 34246317)
14. Hand T, Cui W, Jung Y, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM: Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci USA 2010;107:16601-16606.
15. El-Hodhod MA, Nassar MF, Zaki MM, Moustafa A: Apoptotic changes in lymphocytes of protein energy malnutrition children. Nutr Res 2005;25:21-29. (Pubitemid 40439190)
16. Nassar M, El-Batrawy S, Nagy N: CD95 expression in white blood cells of malnourished infants during hospitalization and catch-up growth. East Mediterr Health J 2009;15:574-83.
17. Moser B, Loetscher P: Lymphocyte traffic control by chemokines. Nat Immunol 2001;2:123-128. (Pubitemid 33707929)
18. Thelen M: Dancing to the tune of chemokines. Nat Immunol 2001;2:129-134.
19. Badr G, Borhis G, Treton D, Moog C, Garraud O, Richard Y: HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21. J Immunol 2005;175:302-310. (Pubitemid 40884332)
20. Badr G, Borhis G, Treton D, Richard Y: IFN {alpha} enhances human B-cell chemotaxis by modulating ligand-induced chemokine receptor signaling and internalization. Int Immunol 2005;17:459-467. (Pubitemid 40568121)
21. Badr G, Bédard, N, Abdel Hakeem M, Trautmann L, Willems B, Villeneuve J, Haddad E, Sékaly R, Bruneau J, Shoukry N: Early interferon therapy for HCV rescues polyfunctional virus-specific CD8+ long- lived memory T cells. J Virol 2008;82:10017-10031.
22. Hasselbalch H, Ersboll AK, Jeppesen, DL, Nielsen, MB: Thymus size in infants from birth until 24 months of age evaluated by ultrasound. Acta Radiol 1999;40:41-44.
23. Collinson AC, Moore SE, Cole TJ, Prentice AM: Birth season and environmental influences on patterns of thymic growth in rural Gambian infants. Acta Paediatr 2003;92:1014-1020. (Pubitemid 37239160)
24. Savino W: The thymus gland is a target in malnutrition. Eur J Clin Nutr 2002;56:S46-49.
25. Nathan C, Sporn M: Cytokines in context. J Cell Biol 1991;113:981-986. (Pubitemid 21909731)
26. Malek TR: T helper cells, IL-2, and the generation of cytotoxic T-cell responses. Trends Immunol 2002;23:465-467.
27. Moon J, Nelson B: Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor. J Immunol 2001;167:2714-2723. (Pubitemid 32768902)
28. Lali V, Crawley J, McCulloch D, Foxwell B: A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation. J Immunol 2004;172:3527-3534. (Pubitemid 38337933)
29. Mui A, Wakao L, Harada N, O'Farrell A, Miyajima A: Interleukin-3, granulocytemacrophage colony-stimulating factor, and interleukin- 5 transduce signals through two forms of STAT5. J Leukoc Biol 1995;57:799-803.
30. Uetrecht AC, Bear JE: Coronins: the return of the crown. Trends Cell Biol 2006;16:421-426.
31. Gomez T, Hamann M, McCarney S, Savoy D, Lubking C, Heldebrant M, Labno C, McKean D, McNiven M, Burkhardt J, Billadeau D: Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol 2005;6:261-270. (Pubitemid 41724763)