Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy

Journal of Neuroscience

Volumn 35, Issue 16, 2015, Pages 6495-6505

  Hawkins Salsbury, Jacqueline A ^a   Shea, Lauren ^a   Jiang, Xuntian ^a   Hunter, Daniel A ^a   Miguel Guzman, A ^b   Reddy, Adarsh S ^a   Qin, Elizabeth Y ^a   Li, Yedda ^a   Gray, Steven J ^c   Ory, Daniel S ^a   Sands, Mark S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Dysmyelination; Gene therapy; Globoid cell leukodystrophy; Krabbe disease; Lysosomal storage disease

Indexed keywords

BETA ACTIN; CD68 ANTIGEN; CHEMOKINE; CYCLOSERINE; GALACTOSYLCERAMIDASE; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 10; PSYCHOSINE; VIRUS VECTOR; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BODY WEIGHT; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DOT HYBRIDIZATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; FLOW CYTOMETRY; GENE THERAPY; GENOTYPE; GLOBOID CELL LEUKODYSTROPHY; IMMUNOHISTOCHEMISTRY; LIFESPAN; MALE; MORPHOMETRICS; MOTOR PERFORMANCE; MOUSE; MYELINATION; NONHUMAN; PERIPHERAL NEUROPATHY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCIATIC NERVE; ANIMAL; BRAIN; DRUG EFFECTS; GENETICS; INBRED MOUSE STRAIN; LEUKODYSTROPHY, GLOBOID CELL; METABOLISM; MULTIMODALITY CANCER THERAPY; MYELIN SHEATH; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BODY WEIGHT; BONE MARROW TRANSPLANTATION; BRAIN; COMBINED MODALITY THERAPY; CYCLOSERINE; CYTOKINES; FEMALE; GALACTOSYLCERAMIDASE; GENETIC THERAPY; LEUKODYSTROPHY, GLOBOID CELL; MALE; MICE; MICE, INBRED STRAINS; MOTOR SKILLS; MYELIN SHEATH; PSYCHOSINE; SCIATIC NERVE;

EID: 84929340483     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4199-14.2015     Document Type: Article

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