Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy

Molecular Therapy

Volumn 15, Issue 1, 2007, Pages 44-52

  Lin, Darshong ^a,b   Donsante, Anthony ^a   Macauley, Shannon ^a   Levy, Beth ^c   Vogler, Carole ^c   Sands, Mark S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSYLCERAMIDASE;

ADENO ASSOCIATED VIRUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BONE MARROW TRANSPLANTATION; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CHIMERA; CONTROLLED STUDY; DATA ANALYSIS; DEGENERATIVE DISEASE; DEMYELINATION; ENZYME DEFICIENCY; GENETIC DISORDER; GLOBOID CELL LEUKODYSTROPHY; HYPOTHESIS; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; MOUSE STRAIN; NONHUMAN; PARVOVIRUS VECTOR; VIRAL GENE THERAPY;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; BODY WEIGHT; BONE MARROW TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; CHIMERISM; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE THERAPY; LEUKODYSTROPHY, GLOBOID CELL; LONGEVITY; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY; TISSUE DONORS; TRANSPLANTATION CONDITIONING;

MURINAE;

EID: 33845983322     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/sj.mt.6300026     Document Type: Article

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