Amyloid-β and tau dynamics in human brain interstitial fluid in patients with suspected normal pressure hydrocephalus

Journal of Alzheimer's Disease

Volumn 46, Issue 1, 2015, Pages 261-269

  Herukka, Sanna Kaisa ^a,b   Rummukainen, Jaana ^b   Ihalainen, Jouni ^a   Von Und Zu Fraunberg, Mikael ^a,b   Koivisto, Anne M ^a,b   Nerg, Ossi ^b   Puli, Lakshman K ^a   Seppälä, Toni T ^a   Zetterberg, Henrik ^c,d   Pyykkö, Okko T ^a,b   Helisalmi, Seppo ^a   Tanila, Heikki ^a   Alafuzoff, Irina ^e,f   Hiltunen, Mikko ^a,b   Rinne, Jaakko ^g   Soininen, Hilkka ^a,b   Jääskeläinen, Juha E ^a,b   Leinonen, Ville ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UPPSALA UNIVERSITY   (Sweden)

^f UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^g TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alzheimer's disease; amyloid ; biomarkers; normal pressure hydrocephalus; tau

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; PHOSPHOPROTEIN; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); APOLIPOPROTEIN E4; PEPTIDE FRAGMENT;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BIOPSY; CEREBROSPINAL FLUID; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; INTERSTITIAL FLUID; INTRACRANIAL PRESSURE MONITORING; MALE; MICRODIALYSIS; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPATHOLOGY; NORMOTENSIVE HYDROCEPHALUS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN PHOSPHORYLATION; VERY ELDERLY; BRAIN; CHI SQUARE DISTRIBUTION; COGNITION DISORDERS; COMPLICATION; EXTRACELLULAR FLUID; GENETICS; METABOLISM; PATHOLOGY;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PEPTIDES; APOLIPOPROTEIN E4; BRAIN; CHI-SQUARE DISTRIBUTION; COGNITION DISORDERS; EXTRACELLULAR FLUID; FEMALE; HUMANS; HYDROCEPHALUS, NORMAL PRESSURE; MALE; MICRODIALYSIS; MIDDLE AGED; PEPTIDE FRAGMENTS; TAU PROTEINS;

EID: 84929337397     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-142862     Document Type: Article

References (27)

1. Walsh DM, Selkoe DJ (2007) A beta oligomers-a decade of discovery. J Neurochem 101, 1172-1184.
2. Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL (2013) Amyloid-β oligomeriza-tion in Alzheimer dementia versus high-pathology controls. Ann Neurol 73, 104-119.
3. Blennow K, Hampel H, Weiner M, Zetterberg H (2010) Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 6, 131-144.
4. Molinuevo JL, Blennow K, Dubois B, Engelborghs S, Lewczuk P, Perret-Liaudet A, Teunissen CE, Parnetti L (2014) The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimers Dement 10, 808-817.
5. Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ (2011) Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. J Neurosci 31, 15861-15869.
6. Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM (2008) Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science 321, 1221-1224.
7. Marklund N, Blennow K, Zetterberg H, Ronne-Engström E, Enblad P, Hillered L (2009) Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. J Neurosurg 110, 1227-1237.
8. Magnoni S, Esparza TJ, Conte V, Carbonara M, Carrabba G, Holtzman DM, Zipfel GJ, Stocchetti N, Brody DL (2012) Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury. Brain 135, 1268-1280.
9. Malm J, Graff-Radford NR, Ishikawa M, Kristensen B, Leinonen V, Mori E, Owler BK, Tullberg M, Williams MA, Relkin NR (2013) Influence of comorbidities in idiopathic normal pressure hydrocephalus-research and clinical care. A report of the ISHCSF task force on comorbidities in INPH. Fluids Barriers CNS 20, 22.
10. Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I (2012) Post-mortem findings in 10 patients with presumed normal pressure hydrocephalus and review of the literature. Neuropathol Appl Neurobiol 38, 72-86.
11. Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J, Alafuzoff I (2010) Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease. Ann Neurol 68, 446-453.
12. Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka SK (2012) CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings. Neurology 78, 1568-1575.
13. Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMat-tos RB, Holtzman DM (2003) In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. J Neurosci 23, 8844-8853.
14. Tsukamoto K, Watanabe T, Matsushima T, Kinoshita M, Kato H, Hashimoto Y, Kurokawa K, Teramoto T (1993) Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med 121, 598-602.
15. Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Ala-fuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V (2014) Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus. PLoS One 9, e91974.
16. DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 41, 193-202.
17. Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM (2011) Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med 3, 89ra57.
18. Herukka SK, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T (2007) CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI. Neurobiol Aging 28, 507-514.
19. Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JAA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M (2012) APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. J Neurol Neuro-surg Psychiatry 83, 1119-1124.
20. Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM (2007) Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity. Proc Natl Acad Sci USA 104, 10673-10678.
21. Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM (2014) Neuronal activity regulates extracellular tau in vivo. J Exp Med 211, 387-393.
22. Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326, 1005-1007.
23. Bateman RJ, Wen G, Morris JC, Holtzman DM (2007) Fluctuations of CSF amyloid-beta levels: Implications for a diagnostic and therapeutic biomarker. Neurology 68, 666-669.
24. Huang Y, Potter R, Sigurdson W, Santacruz A, Shih S, Ju YE, Kasten T, Morris JC, Mintun M, Duntley S, Bateman RJ (2012) Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system. Arch Neurol 69, 51-58.
25. Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT (2013) Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. FASEB J 27, 3239-3248.
26. Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM (2011) In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci 31, 13110-13117.
27. Jeppsson A, Zetterberg H, Blennow K, Wikkelsø C (2013) Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers. Neurology 80, 1385-1392.