Hyperpolarized Gas MR Imaging: Technique and Applications

Magnetic Resonance Imaging Clinics of North America

Volumn 23, Issue 2, 2015, Pages 217-229

  Roos, Justus E ^a   McAdams, Holman P ^a   Kaushik, S Sivaram ^a,b   Driehuys, Bastiaan ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Duke University   (United States)

Author keywords

Hyperpolarized gas; Lung imaging; MR imaging; Pulmonary gas exchange; Pulmonary ventilation; Xenon (129Xe)

Indexed keywords

HELIUM; XENON; ISOTOPE;

ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIFFUSION WEIGHTED IMAGING; EMPHYSEMA; HEALTH CARE COST; HUMAN; HYPERPOLARIZED GAS NUCLEAR MAGNETIC RESONANCE IMAGING; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IMAGE QUALITY; LUNG DISEASE; LUNG FUNCTION TEST; LUNG VENTILATION; MORPHOMETRICS; NUCLEAR MAGNETIC RESONANCE IMAGING; POLARIZATION; RADIATION PHYSICS; RADIOFREQUENCY; RADIOLOGICAL PROCEDURES; REVIEW; SIGNAL NOISE RATIO; THORAX RADIOGRAPHY; LUNG; LUNG GAS EXCHANGE; PHYSIOLOGY; PROCEDURES;

DIFFUSION MAGNETIC RESONANCE IMAGING; HELIUM; HUMANS; ISOTOPES; LUNG; MAGNETIC RESONANCE IMAGING; PULMONARY GAS EXCHANGE; XENON ISOTOPES;

EID: 84929317815     PISSN: 10649689     EISSN: 15579786     Source Type: Journal    
DOI: 10.1016/j.mric.2015.01.003     Document Type: Review

References (49)

1. Hoyert D.L., Xu J. Deaths: preliminary data for 2011. Natl Vital Stat Rep 2012, 61(6):1-51.
2. Barnett S.B., Nurmagambetov T.A. Costs of asthma in the United States: 2002-2007. JAllergy Clin Immunol 2011, 127(1):145-152.
3. Nalysnyk L., Cid-Ruzafa J., Rotella P., et al. Incidence and prevalence of idiopathic pulmonary fibrosis: review of the literature. Eur Respir Rev 2012, 21(126):355-361.
4. Hogg J.C., Chu F., Utokaparch S., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. NEngl J Med 2004, 350(26):2645-2653.
5. Ashutosh K., Haldipur C., Boucher M.L. Clinical and personality profiles and survival in patients with COPD. Chest 1997, 111(1):95-98.
6. Mahler D.A., Mackowiak J.I. Evaluation of the short-form 36-item questionnaire to measure health-related quality of life in patients with COPD. Chest 1995, 107(6):1585-1589.
7. Nishimura K., Izumi T., Tsukino M., et al. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002, 121(5):1434-1440.
8. Fain S.B., Panth S.R., Evans M.D., et al. Early emphysematous changes in asymptomatic smokers: detection with 3HE MR imaging 1. Radiology 2006, 239(3):875-883.
9. Kirby M., Mathew L., Wheatley A., et al. Chronic obstructive pulmonary disease: longitudinal hyperpolarized 3He MR imaging 1. Radiology 2010, 256(1):280-289.
10. McAdams H.P., Palmer S.M., Donnelly L.F., et al. Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results. AJR Am J Roentgenol 1999, 173(4):955-959.
11. McMahon C.J., Dodd J.D., Hill C., et al. Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry. Eur Radiol 2006, 16(11):2483-2490.
12. Mentore K., Froh D.K., de Lange E.E., et al. Hyperpolarized HHe 3 MRI of the lung in cystic fibrosis. Acad Radiol 2005, 12(11):1423-1429.
13. Salerno M., de Lange E.E., Altes T.A., et al. Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes-initial experience1. Radiology 2002, 222(1):252-260.
14. Kramer D. For some, helium-3 supply picture is brightening. Physics Today 2011.
15. Kaushik S.S., Freeman M.S., Yoon S.W., et al. Measuring diffusion limitation with a perfusion-limited gas-hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis. JAppl Physiol (1985) 2014, 117(6):577-585.
16. Albert M.S., Cates G.D., Driehuys B., et al. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature 1994, 370(6486):199-201.
17. Mugler J.P., Driehuys B., Brookeman J.R. MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magn Reson Med 1997, 37:809-815.
18. Kennedy R.R., Stokes J.W., Downing P. Anaesthesia and the 'inert' gases with special reference to xenon. Anaesth Intensive Care 1992, 20(1):66-70.
19. Ebert M., Grossmann T., Heil W., et al. Nuclear magnetic resonance imaging with hyperpolarised helium-3. Lancet 1996, 347(9011):1297-1299.
20. MacFall J.R., Charles H.C., Black R.D., et al. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology 1996, 200(2):553-558.
21. van Beek E.J., Dahmen A.M., Stavngaard T., et al. Hyperpolarised 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial. Eur Respir J 2009, 34(6):1311-1321.
22. Chen X.J., Möller H.E., Chawla M.S., et al. Spatially resolved measurements of hyperpolarized gas properties in the lung invivo. Part I: diffusion coefficient. Magn Reson Med 1999, 42(4):721-728.
23. Kaushik S.S., Cleveland Z.I., Cofer G.P., et al. Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med 2011, 65(4):1154-1165.
24. Swift A.J., Wild J.M., Fichele S., et al. Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI. Eur J Radiol 2005, 54(3):352-358.
25. Patz S., Hersman F.W., Muradian I., et al. Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality?. Eur J Radiol 2007, 64(3):335-344.
26. Latchaw R.E., Yonas H., Pentheny S.L., et al. Adverse reactions to xenon-enhanced CT cerebral blood flow determination. Radiology 1987, 163(1):251-254.
27. Driehuys B., Martinez-Jimenez S., Cleveland Z.I., et al. Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology 2012, 262(1):279-289.
28. Ruset I.C., Ketel S., Hersman F.W. Optical pumping system design for large production of hyperpolarized Xe 129. Phys Rev Lett 2006, 96(5):53002.
29. Shukla Y., Wheatley A., Kirby M., et al. Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease. Acad Radiol 2012, 19(8):941-951.
30. Bouchiat M.A., Carver T.R., Varnum C.M. Nuclear polarization in He 3 gas induced by optical pumping and dipolar exchange. Phys Rev Lett 1960.
31. Kastler A. The optical production and the optical detection of an inequality of population of the levels of spatial quantification of atoms. Application to the experiments. JPhys Radium 1950.
32. Goodson B.M. Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms. JMagn Reson 2002, 155(2):157-216.
33. Walker T.G., Happer W. Spin-exchange optical pumping of noble-gas nuclei. Rev Mod Phys 1997, 69(2):629-642.
34. Nikolaou P., Coffey A.M., Walkup L.L., et al. Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proc Natl Acad Sci U S A 2013, 110:14150-14155.
35. Zhao L., Albert M.S. Biomedical imaging using hyperpolarized noble gas MRI: pulse sequence considerations. Nucl Instrum Methods Phys Res A 1998, 402:454-460.
36. 3He MRI in mouse models of asthma. Magn Reson Med 2007, 58(5):893-900.
37. Marshall H., Deppe M.H., Parra-Robles J., et al. Direct visualisation of collateral ventilation in COPD with hyperpolarised gas MRI. Thorax 2012, 67(7):613-617.
38. Svenningsen S., Kirby M., Starr D., et al. Hyperpolarized (3) He and (129) Xe MRI: differences in asthma before bronchodilation. JMagn Reson Imaging 2013, 38(6):1521-1530.
39. Wang C., Mugler J.P., de Lange E.E., et al. Lung injury induced by secondhand smoke exposure detected with hyperpolarized helium-3 diffusion MR. JMagn Reson Imaging 2014, 39(1):77-84.
40. Fain S.B., Altes T.A., Panth S.R., et al. Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI. Acad Radiol 2005, 12(11):1385-1393.
41. Diaz S., Casselbrant I., Piitulainen E., et al. Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references. Eur J Radiol 2009, 71(2):257-263.
42. Weathersby P.K., Homer L.D. Solubility of inert gases in biological fluids and tissues: a review. Undersea Biomed Res 1980, 7(4):277-296.
43. Mugler J.P., Altes T.A., Ruset I.C., et al. Image-based measurement of T2* for dissolved-phase Xe129 in the human lung 2012, International Society for Magnetic Resonance in Medicine, Berkeley (CA).
44. Ruppert K., Brookeman J.R., Hagspiel K.D., et al. Probing lung physiology with xenon polarization transfer contrast (XTC). Magn Reson Med 2000, 44(3):349-357.
45. Cleveland Z.I., Cofer G.P., Metz G., et al. Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans. PLoS One 2010, 5(8):e12192.
46. Mugler J.P., Altes T.A., Ruset I.C., et al. Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc Natl Acad Sci U S A 2010, 107:21707-21712.
47. Qing K., Ruppert K., Jiang Y., et al. Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI. JMagn Reson Imaging 2014, 39(2):346-359.
48. Kaushik S.S., Robertson S.H., Freeman M.S., et al. Imaging hyperpolarized 129Xe uptake in pulmonary barrier and red blood cells using a 3D Radial 1-point Dixon approach: results in healthy volunteers and subjects with pulmonary fibrosis 2014, International Society for Magnetic Resonance in Medicine, Berkeley (CA).
49. Johnson K.M., Fain S.B., Schiebler M.L., et al. Optimized 3D ultrashort echo time pulmonary MRI. Magn Reson Med 2013, 70(5):1241-1250.