Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney

Journal of the American Society of Nephrology

Volumn 26, Issue 5, 2015, Pages 1027-1038

  Dimke, Henrik ^a,c,d   Sparks, Matthew A ^e   Thomson, Benjamin R ^b   Frische, Sebastian ^d   Coffman, Thomas M ^e,f   Quaggin, Susan E ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e DUKE UNIVERSITY   (United States)

^f DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; ELECTROLYTE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY DENSITY; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; ELECTROLYTE EXCRETION; EMBRYO; ERYTHROCYTE COUNT; FIBROBLAST; GENE DELETION; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HISTOLOGY; KIDNEY BLOOD VESSEL; KIDNEY TUBULE; KIDNEY TUBULE CELL; MEAN CORPUSCULAR HEMOGLOBIN; MESANGIUM CELL; MICROVASCULATURE; MOUSE; NEPHRON; NONHUMAN; POLYCYTHEMIA; PRIORITY JOURNAL; WILD TYPE; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; MALE; METABOLISM; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANIMALS; BLOOD PRESSURE; ELECTROLYTES; ERYTHROPOIETIN; HEMATOCRIT; KIDNEY TUBULES; MALE; MICE, INBRED C57BL; MICROVESSELS; POLYCYTHEMIA; RECEPTOR CROSS-TALK; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84929316625     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2014010060     Document Type: Article

References (33)

1. Kriz W: Renal medullary circulation: Morphological characteristics of vessels and their organization. Klin Wochenschr 60: 1063-1069, 1982
2. Brezis M, Heyman SN, Dinour D, Epstein FH, Rosen S: Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys. J Clin Invest 88: 390-395, 1991
3. Nangaku M: Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure. J Am Soc Nephrol 17: 17-25, 2006
4. Donnelly S: Why is erythropoietin made in the kidney? The kidney functions as a 'critmeter' to regulate the hematocrit. Adv Exp Med Biol 543: 73-87, 2003
5. Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M: Plasticity of renal erythropoietin-producing cells governs fibrosis. J Am Soc Nephrol 24: 1599-1616, 2013
6. Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, Yamamoto M: A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nat Commun 4: 1950, 2013
7. Marti HH, Risau W: Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc Natl Acad Sci U S A 95: 15809-15814, 1998
8. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290: H560-H576, 2006
9. Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP, Kikkawa Y, Miner JH, Quaggin SE: Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 111: 707-716, 2003
10. Eremina V, Quaggin SE: The role of VEGF-A in glomerular development and function. Curr Opin Nephrol Hypertens 13:9-15, 2004
11. Miquerol L, Gertsenstein M, Harpal K, Rossant J, Nagy A: Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol 212: 307-322, 1999
12. Miquerol L, Langille BL, Nagy A: Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development 127: 3941-3946, 2000
13. Ema M, Takahashi S, Rossant J: Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood 107:111-117, 2006
14. Robert B, St John PL, Hyink DP, Abrahamson DR: Evidence that embryonic kidney cells expressing flk-1 are intrinsic, vasculogenic angioblasts. Am J Physiol 271: F744-F753, 1996
15. Robert B, St John PL, Abrahamson DR: Direct visualization of renal vascular morphogenesis in Flk1 heterozygous mutant mice. Am J Physiol 275: F164-F172, 1998
16. Maxwell PH, Ferguson DJ, Nicholls LG, Johnson MH, Ratcliffe PJ: The interstitial response to renal injury: Fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression. Kidney Int 52: 715-724, 1997
17. Gerber HP, Hillan KJ, Ryan AM, Kowalski J, Keller GA, Rangell L, Wright BD, Radtke F, Aguet M, Ferrara N: VEGF is required for growth and survival in neonatal mice. Development 126: 1149-1159, 1999
18. Traykova-Brauch M, Schönig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R: An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med 14: 979-984, 2008
19. Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE: VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358: 1129-1136, 2008
20. Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, Yamamoto M: Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice. PLoS ONE 6: e25839, 2011
21. Osborne WR, Ramesh N, Lau S, Clowes MM, Dale DC, Clowes AW: Gene therapy for long-term expression of erythropoietin in rats. Proc Natl Acad Sci U S A 92: 8055-8058, 1995
22. Boor P, Floege J: The renal (myo-)fibroblast: A heterogeneous group of cells. Nephrol Dial Transplant 27: 3027-3036, 2012
23. LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R: Origin and function of myofibroblasts in kidney fibrosis. Nat Med 19: 1047-1053, 2013
24. Theilig F, Enke AK, Scolari B, Polzin D, Bachmann S, Koesters R: Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. Am J Pathol 179: 2177-2188, 2011
25. Chen YT, Chang FC, Wu CF, Chou YH, Hsu HL, Chiang WC, Shen J, Chen YM, Wu KD, Tsai TJ, Duffield JS, Lin SL: Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int 80: 1170-1181, 2011
26. Steeghs N, Rabelink TJ, op't Roodt J, Batman E, Cluitmans FH, Weijl NI, de Koning E, Gelderblom H: Reversibility of capillary density after discontinuation of bevacizumab treatment. Ann Oncol 21: 1100-1105, 2010
27. Hakroush S, Moeller MJ, Theilig F, Kaissling B, Sijmonsma TP, Jugold M, Akeson AL, Traykova-Brauch M, Hosser H, Hähnel B, Gröne HJ, Koesters R, Kriz W: Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. Am J Pathol 175: 1883-1895, 2009
28. Belteki G, Haigh J, Kabacs N, Haigh K, Sison K, Costantini F, Whitsett J, Quaggin SE, Nagy A: Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33: e51, 2005
29. Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM: Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A 103: 17985-17990, 2006
30. Butz GM, Davisson RL: Long-term telemetric measurement of cardiovascular parameters in awake mice: A physiological genomics tool. Physiol Genomics 5: 89-97, 2001
31. Dimke H, Flyvbjerg A, Bourgeois S, Thomsen K, Frøkiaer J, Houillier P, Nielsen S, Frische S: Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2. Am J Physiol Renal Physiol 292: F723-F735, 2007
32. Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A: Fiji: An open-source platform for biological-image analysis. Nat Methods 9: 676-682, 2012
33. Cruz-Orive LM, Weibel ER: Recent stereological methods for cell biology: A brief survey. Am J Physiol 258: L148-L156, 1990