Setup and validation of shake-flask procedures for the determination of partition coefficients (log D) from low drug amounts

European Journal of Pharmaceutical Sciences

Volumn 76, Issue , 2015, Pages 181-191

  Andrés, Axel ^a   Rosés, Martí ^a   Ràfols, Clara ^a   Bosch, Elisabeth ^a   Espinosa, Sonia ^b   Segarra, Víctor ^b   Huerta, Josep M ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Computational and Structural Drug Discovery Department R and D Centre Almirall SA ^*  (Spain)

Author keywords

Hydrophobicity; Lipophilicity; logD; logPo w< inf>; Octanol water partition; Shake flask technique

Indexed keywords

ACETANILIDE; ACETOPHENONE; ANTHRACENE; ATENOLOL; BENZOIC ACID; BUTYROPHENONE; CAFFEINE; COLCHICINE; HALOPERIDOL; HYDROCORTISONE; KETOCONAZOLE; METOPROLOL; NAPHTHALENE; OCTANOL; PARACETAMOL; PHENANTHRENE; PHENOTHIAZINE; PHOSPHATE; PROCAINE; PROPIOPHENONE; RESERPINE; SALICYLIC ACID; THEOPHYLLINE; THYMOL; WARFARIN; BUFFER; DIMETHYL SULFOXIDE; DRUG; SOLVENT; WATER;

CHEMICAL PROCEDURES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; PARTITION COEFFICIENT; PARTITION RATIO; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SHAKE FLASK METHOD; SOLUBILITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DEVELOPMENT; LIQUID CHROMATOGRAPHY; PH; PHARMACEUTICS; PROCEDURES; REPRODUCIBILITY;

1-OCTANOL; BUFFERS; CHROMATOGRAPHY, LIQUID; DIMETHYL SULFOXIDE; DRUG DISCOVERY; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 84929309802     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.05.008     Document Type: Review

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