Chick embryo chorioallantoic membrane (CAM): An alternative predictive model in acute toxicological studies for anti-cancer drugs

Experimental Animals

Volumn 64, Issue 2, 2014, Pages 129-138

  Kue, Chin Siang ^a,b   Tan, Kae Yi ^a,b   Lam, May Lynn ^b   Lee, Hong Boon ^a,b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b Sime Darby Medical Centre   (Malaysia)

Author keywords

3R s approach; Alternative predictive model; Chick embryo chorioallantoic membrane (CAM); Median lethal dose (LD50); Preclinical toxicology

Indexed keywords

ALOIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; MELPHALAN; MITOMYCIN; PACLITAXEL; VINCRISTINE;

ARTICLE; CHICK EMBRYO; CHICKEN; CHORIOALLANTOIS; CLINICAL ASSESSMENT; CORRELATION COEFFICIENT; DRUG DETERMINATION; DRUG FORMULATION; EMBRYO; EMBRYO DEVELOPMENT; LETHAL DOSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PREDICTION; SURVIVAL; SURVIVAL DOSE; TOXICITY TESTING; ANIMAL; ANIMAL MODEL; ANIMAL TESTING ALTERNATIVE; COMPARATIVE STUDY; DRUG EFFECTS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LD50; MOUSE; PROCEDURES; RAT;

MUS; RATTUS; RODENTIA;

ANIMAL TESTING ALTERNATIVES; ANIMALS; ANTINEOPLASTIC AGENTS; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; LETHAL DOSE 50; MICE; MODELS, ANIMAL; RATS; TOXICITY TESTS, ACUTE;

EID: 84929304876     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.14-0059     Document Type: Article

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