Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1637, Issue 2, 2003, Pages 151-155

  Elas, Martyna ^a,b,c,d   Parasca, Adrian ^a,b   Grdina, David J ^b   Halpern, Howard J ^a,b  

^a Dept of Radiat and Cell Oncology   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d MC1105 ^*  (United States)

Author keywords

Amifostine; Bioavailability; EPR; Nitroxide; Radioprotection

Indexed keywords

AMIFOSTINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; ELECTRON SPIN RESONANCE; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE;

ANIMALIA;

EID: 0037456708     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(02)00228-4     Document Type: Article

References (21)

1. Yuhas J. A more general role for WR-2721 in cancer therapy. Br. J. Cancer. 41:1980;832-834.
2. Yuhas J. Protective drugs in cancer therapy: optimal clinical testing and future directions. Int. J. Radiat. Oncol. Biol. Phys. 8:1982;513-517.
3. Yuhas J., Afzal S., Afzal V. Variation in normal tissue responsiveness to WR-2721. Int. J. Radiat. Oncol. Biol. Phys. 10:1984;1537-1539.
4. Turrisi A., Glover D., Hurwitz S., Glick J., Norfleet A., Weiler C., Yuhas J., Kligerman M. Final report of the phase I trial of single-dose WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid]. Cancer Treat. Rep. 70:1986;1389-1393.
5. Yuhas J., Spellman J., Culo F. The role of WR-2721 in radiotherapy and/or chemotherapy. Cancer Clin. Trials. 3:1980;211-216.
6. Grdina D.J., Kataoka Y., Murley J.S. Amifostine: mechanisms of action underlying cytoprotection and chemoprevention. Drug Metab. Drug Interac. 16:2000;237-279.
7. Vijgh W.J.F.v.d., Korst A.E.C. Amifostine (ethyol): pharmacokinetics and pharmacodynamic effects in vivo. Eur. J. Cancer. 32A:1996;S26-S30.
8. Miura Y., Anzai K., Ueda J., Ozawa T. Novel approach to in vivo screening for radioprotective activity in whole mice: in vivo electron spin resonance study probing the redox reaction of nitronyl. J. Radiat. Res. 41:2000;103-111.
9. Miura Y., Anzai K., Urano S., Ozawa T. In vivo electron paramagnetic resonance studies on oxidative stress caused by X-irradiation in whole mice. Free Radic. Biol. Med. 23:1997;533-540.
10. Davidson D.E., Grenan M.M., Sweeney T.R. Brady L.W. Radiation Sensitizers, their Use in Clinical Management of Cancer. vol. 5:1980;309-320.
11. Robinson B.H., Mailer C., Reese A.W. Linewidth analysis of spin labels in liquids, I. Theory and data analysis. J. Magn. Reson. 138:1999;199-209.
12. Glantz S. Primer of Biostatistics. 4th ed. 1997;McGraw-Hill, New York.
13. Shaw L.M., Bonner H.S., Shuchter L., Schiller J., Lieberman R. Pharmacokinetics of amifostine: effects of dose and method of administration. Semin. Oncol. 26:1999;34-36.
14. Mitchell J.L.A., Judd G.G., Diveley R.R., Choe C.Y., Leyser A. Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278. Carcinogenesis. 16:1995;3063-3068.
15. Kocherginsky N., Swartz H.M. Nitroxide Spin Labels. Reactions in Biology and Chemistry. 1st ed. 1995;CRC, Boca Raton.
16. Swartz H.M., Sentjurc M., Morse P.D. Cellular metabolism of water-soluble nitroxides: effect on rate of reduction of cell/nitroxide ratio, oxygen concentration, and permeability of nitroxides. Biochim. Biophys. Acta. 888:1986;82-90.
17. Samuni A., Krishna C.M., Riesz P., Finkelstein E., Russo A. A novel metal-free low molecular weight superoxide dismutase mimic. J. Biol. Chem. 263:1988;17921-17924.
18. Kroll C., Langner A., Borchert H.H. Nitroxide metabolism in the human keratinocyte cell line HaCaT. Free Radic. Biol. Med. 26:1999;850-857.
19. Rosen G.M., Britigan B.E., Halpern H.J., Pou S. Free Radicals. Biology and Detection by Spin Trapping. 1999;Oxford Univ. Press, New York.
20. Takeshita K., Hamada A., Utsumi H. Mechanism related to reduction of radical in mouse lung using an L-band ESR spectrometer. Free Radic. Biol. Med. 26:1999;951-960.
21. Han J.Y., Takeshita K., Utsumi H. Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles. Free Radic. Biol. Med. 30:2001;516-525.