Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity

Aging

Volumn 7, Issue 4, 2015, Pages 223-232

  Xian, Li ^a   Hou, Siyuan ^a   Huang, Zan ^a   Tang, An ^a   Shi, Peiliang ^a   Wang, Qinghua ^a   Song, Anying ^a   Jiang, Shujun ^a   Lin, Zhaoyu ^a   Guo, Shiying ^a   Gao, Xiang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Disorder; Glucose; Insulin signaling; Liver; PP2A

Indexed keywords

GLUCOSE; INSULIN; LIPID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; PROTEIN PHOSPHATASE 2C;

ANIMAL; BLOOD; GENETICS; GLUCOSE INTOLERANCE; HOMEOSTASIS; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIPID DIET; LIVER; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DIET, HIGH-FAT; GLUCOSE; GLUCOSE INTOLERANCE; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; LIPIDS; LIVER; MICE; MICE, KNOCKOUT; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN PHOSPHATASE 2C; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84929302268     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100725     Document Type: Article

References (42)

1. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988; 37:1595-1607.
2. Kaidanovich O and Eldar-Finkelman H. The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Expert opinion on therapeutic targets. 2002; 6:555-561.
3. Biddinger SB and Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annual review of physiology. 2006; 68:123-158.
4. Saltiel AR and Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001; 414:799-806.
5. White MF. Insulin signaling in health and disease. Science. 2003; 302:1710-1711.
6. Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, 3rd, Kaestner KH, Bartolomei MS, Shulman GI and Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 2001; 292:1728-1731.
7. Rintelen F, Stocker H, Thomas G and Hafen E. PDK1 regulates growth through Akt and S6K in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98:15020-15025.
8. Sarbassov DD, Guertin DA, Ali SM and Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005; 307:1098-1101.
9. Taniguchi CM, Emanuelli B and Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nature reviews Molecular cell biology. 2006; 7:85-96.
10. Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR and Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature medicine. 2012; 18:388-395.
11. Manning BD and Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007; 129:1261-1274.
12. Eldar-Finkelman H and Krebs EG. Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci U S A. 1997; 94:9660-9664.
13. Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R and Zick Y. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. J Biol Chem. 1999; 274:28816-28822.
14. Millward TA, Zolnierowicz S and Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci. 1999; 24:186-191.
15. Arroyo JD and Hahn WC. Involvement of PP2A in viral and cellular transformation. Oncogene. 2005; 24:7746-7755.
16. Schonthal AH. Role of serine/threonine protein phosphatase 2A in cancer. Cancer letters. 2001; 170:1-13.
17. Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I and Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. The Journal of biological chemistry. 2000; 275:5535-5544.
18. Standaert ML, Bandyopadhyay G, Sajan MP, Cong L, Quon MJ and Farese RV. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport. J Biol Chem. 1999; 274:14074-14078.
19. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A and Olefsky JM. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol. 2004; 24:8778-8789.
20. Galbo T, Olsen GS, Quistorff B and Nishimura E. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. PLoS One. 2011; 6:e27424.
21. Bernsmeier C, Calabrese D, Heim MH and Duong HT. Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1alpha and dephosphorylation of FoxO1. Journal of viral hepatitis. 2014; 21:9-18.
22. Bernsmeier C, Duong FH, Christen V, Pugnale P, Negro F, Terracciano L and Heim MH. Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. Journal of hepatology. 2008; 49:429-440.
23. Khew-Goodall Y and Hemmings BA. Tissue-specific expression of mRNAs encoding alpha-and beta-catalytic subunits of protein phosphatase 2A. FEBS Lett. 1988; 238:265-268.
24. Gotz J, Probst A, Ehler E, Hemmings B and Kues W. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998; 95:12370-12375.
25. Gotz J, Probst A, Mistl C, Nitsch RM and Ehler E. Distinct role of protein phosphatase 2A subunit Calpha in the regulation of Ecadherin and beta-catenin during development. Mechanisms of development. 2000; 93:83-93.
26. Gu P, Qi X, Zhou Y, Wang Y and Gao X. Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012; 50:429-436.
27. Jouihan HA. Measurement of Liver Triglyceride Content. Bioprotocol. 2012; 2.
28. Cline GW, Johnson K, Regittnig W, Perret P, Tozzo E, Xiao L, Damico C and Shulman GI. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002; 51:2903-2910.
29. Shulman GI, Cline G, Schumann WC, Chandramouli V, Kumaran K and Landau BR. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans. The American journal of physiology. 1990; 259:E335-341.
30. Kim YJ and Park T. Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet. Nutr Res. 2008; 28:414-422.
31. Cazzolli R, Carpenter L, Biden TJ and Schmitz-Peiffer C. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes. 2001; 50:2210-2218.
32. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999; 96:857-868.
33. Rena G, Guo S, Cichy SC, Unterman TG and Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. The Journal of biological chemistry. 1999; 274:17179-17183.
34. Lin HV and Accili D. Hormonal regulation of hepatic glucose production in health and disease. Cell metabolism. 2011; 14:9-19.
35. Galbo T, Perry RJ, Nishimura E, Samuel VT, Quistorff B and Shulman GI. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging. 2013; 5:770-781.
36. MacAulay K, Doble BW, Patel S, Hansotia T, Sinclair EM, Drucker DJ, Nagy A and Woodgett JR. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell metabolism. 2007; 6:329-337.
37. Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995; 378:785-789.
38. McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R and Alessi DR. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. The EMBO journal. 2005; 24:1571-1583.
39. Bouskila M, Hunter RW, Ibrahim AF, Delattre L, Peggie M, van Diepen JA, Voshol PJ, Jensen J and Sakamoto K. Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. Cell metabolism. 2010; 12(5):456-466.
40. Bouskila M, Hirshman MF, Jensen J, Goodyear LJ and Sakamoto K. Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle. American journal of physiology Endocrinology and metabolism. 2008; 294:E28-35.
41. Wan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC and Birnbaum MJ. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell metabolism. 2013; 18:99-105.
42. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G and Melchionda N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001; 50:1844-1850.