Cytokines for monitoring anti-tuberculous therapy: A systematic review

Tuberculosis

Volumn 95, Issue 3, 2015, Pages 217-228

  Clifford, Vanessa ^a   Zufferey, Christel ^a   Street, Alan ^b   Denholm, Justin ^b   Tebruegge, Marc ^a,c   Curtis, Nigel ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Antibiotics; Cytokines; Diagnosis; Immunomodulation; Mycobacterium tuberculosis; Tuberculosis

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUBERCULOSTATIC AGENT;

CYTOKINE RESPONSE; DRUG MONITORING; HUMAN; LONGITUDINAL STUDY; METHODOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVIEW; STUDY DESIGN; SYSTEMATIC REVIEW; TREATMENT RESPONSE; BLOOD; DRUG EFFECTS; IMMUNOLOGY; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS; PREDICTIVE VALUE; REPRODUCIBILITY; TREATMENT OUTCOME; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; BIOMARKERS; CYTOKINES; HUMANS; MYCOBACTERIUM TUBERCULOSIS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; TREATMENT OUTCOME; TUBERCULOSIS;

EID: 84929277877     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2015.01.003     Document Type: Review

References (65)

1. C.M. Perez-Velez Pediatric tuberculosis: new guidelines and recommendations Curr Opin Pediatr 24 3 2012 319 328
2. S.D. Lawn, and A.I. Zumla Tuberculosis Lancet 378 9785 2011 57 72
3. N.P. Spyridis, P.G. Spyridis, A. Gelesme, V. Sypsa, M. Valianatou, F. Metsou, D. Gourgiotis, and M.N. Tsolia The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study Clin Infect Dis 45 6 2007 715 722
4. C.B. Chee, K.W. KhinMar, S.H. Gan, T.M. Barkham, M. Pushparani, and Y.T. Wang Latent tuberculosis infection treatment and T-cell responses to Mycobacterium tuberculosis-specific antigens Am J Respir Crit Care Med 175 3 2007 282 287
5. K. Higuchi, N. Harada, and T. Mori Interferon-gamma responses after isoniazid chemotherapy for latent tuberculosis Respirology 13 3 2008 468 472
6. A.M. Aiken, P.C. Hill, A. Fox, K.P. McAdam, D. Jackson-Sillah, M.D. Lugos, S.A. Donkor, R.A. Adegbola, and R.H. Brookes Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases BMC Infect Dis 6 2006 66
7. T.G. Connell, M.A. Davies, C. Johannisen, K. Wood, S. Pienaar, K.A. Wilkinson, R.J. Wilkinson, H.J. Zar, D. Beatty, M.P. Nicol, N. Curtis, and B. Eley Reversion and conversion of Mycobacterium tuberculosis IFN-gamma ELISpot results during anti-tuberculous treatment in HIV-infected children BMC Infect Dis 10 2010 138
8. M. Pai, R. Joshi, and S. Dogra Serial testing of health care workers for tuberculosis using interferon-gamma assay American journal of respiratory and critical care medicine 174 3 2006 349 355
9. V. Bosshard, P. Roux-Lombard, T. Perneger, M. Metzger, R. Vivien, T. Rochat, and J.P. Janssens Do results of the T-SPOT.TB interferon-gamma release assay change after treatment of tuberculosis? Respir Med 103 1 2009 30 34
10. E. Chiappini, F. Fossi, F. Bonsignori, S. Sollai, L. Galli, and M. de Martino Utility of interferon-gamma release assay results to monitor anti-tubercular treatment in adults and children Clinical therapeutics 34 5 2012 1041 1048
11. T. Barbosa, S. Arruda, M. Chalhoub, F. Oliveira, J.F. Melo Jr., R. Fidelis, A.N. Neto, A.A. Barbosa Jr., and M. Barral-Netto Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients Microbes Infect 8 3 2006 889 897
12. S. Chandrasekhar, and V.K. Perumal Association of increased mycobacterium growth inhibitory factor with antituberculous immunity Eur Respir J 4 7 1991 783 788
13. J. Dirks, U. Sester, J. Elsaser, U. Mack, M. Fousse, G.W. Sybrecht, A. Lalvani, and M. Sester Analysis of tuberculin-specific CD4 T-cell cytokine profiles by flow cytometry distinguishes active tuberculosis from successfully treated disease European Journal of Immunology 39 2009 S261
14. S.L. Feruglio, M. Troseid, J.K. Damas, D. Kvale, and A.M. Dyrhol-Riise Soluble markers of the Toll-like receptor 4 pathway differentiate between active and latent tuberculosis and are associated with treatment responses PLoS One 8 7 2013 e69896
15. R. Hussain, N. Talat, F. Shahid, and G. Dawood Longitudinal tracking of cytokines after acute exposure to tuberculosis: association of distinct cytokine patterns with protection and disease development Clin Vaccine Immunol 14 12 2007 1578 1586
16. P.M. Lago, N. Boechat, D.P. Migueis, A.S. Almeida, L.C. Lazzarini, M.M. Saldanha, A.L. Kritski, and J.L. Ho Lapa e Silva JR. Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence Int J Tuberc Lung Dis 16 5 2012 656 659
17. S.D. Lawn, M.O. Labeta, M. Arias, J.W. Acheampong, and G.E. Griffin Elevated serum concentrations of soluble CD14 in HIV- and HIV+ patients with tuberculosis in Africa: prolonged elevation during anti-tuberculosis treatment Clin Exp Immunol 120 3 2000 483 487
18. J.S. Lee, J.W. Son, S.B. Jung, Y.M. Kwon, C.S. Yang, J.H. Oh, C.H. Song, H.J. Kim, J.K. Park, T.H. Paik, and E.K. Jo Ex vivo responses for interferon-gamma and proinflammatory cytokine secretion to low-molecular-weight antigen MTB12 of Mycobacterium tuberculosis during human tuberculosis Scandinavian Journal of Immunology 64 2 2006 145 154
19. A. Mendez, R. Hernandez-Pando, S. Contreras, D. Aguilar, and G.A.W. Rook CCL2, CCL18 and sIL-4R in renal, meningeal and pulmonary TB; a 2 year study of patients and contacts Tuberculosis 91 2 2011 140 145
20. K.A. Millington, S. Gooding, T.S.C. Hinks, D.J.M. Reynolds, and A. Lalvani Mycobacterium tuberculosis-specific cellular immune profiles suggest bacillary persistence decades after spontaneous cure in untreated tuberculosis Journal of Infectious Diseases 202 11 2010 1685 1689
21. D.J. Montamat-Sicotte, K.A. Millington, C.R. Willcox, S. Hingley-Wilson, S. Hackforth, J. Innes, O.M. Kon, D.A. Lammas, D.E. Minnikin, G.S. Besra, B.E. Willcox, and A. Lalvani A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection Journal of Clinical Investigation 121 6 2011 2493 2503
22. B.G. Oliver, J.H. Elliott, P. Price, M. Phillips, V. Saphonn, M.C. Vun, J.M. Kaldor, D.A. Cooper, and M.A. French Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy Journal of Infectious Diseases 202 11 2010 1728 1737
23. V. Rodrigues, M. Silva, L. Castellano, J. Machado, A. Figueiredo, R. Oliveira, G. Faria, S. Pereira, and D. Rodrigues T cells activation and cytokines balance in active and cured tuberculosis Journal of Immunology 2010 184 (1 MeetingAbstracts)
24. E. Sahiratmadja, B. Alisjahbana, S. Buccheri, D. Di Liberto, T. de Boer, I. Adnan, R. van Crevel, M.R. Klein, K.E. van Meijgaarden, R.H.H. Nelwan, E. van de Vosse, F. Dieli, and T.H.M. Ottenhoff Plasma granulysin levels and cellular interferon-gamma production correlate with curative host responses in tuberculosis, while plasma interferon-gamma levels correlate with tuberculosis disease activity in adults Tuberculosis 87 4 2007 312 321
25. K.B. Sethna, N.F. Mistry, Y. Dholakia, N.H. Antia, and M. Harboe Longitudinal trends in serum levels of mycobacterial secretory (30 kD) and cytoplasmic (65 kD) antigens during chemotherapy of pulmonary tuberculosis patients Scandinavian Journal of Infectious Diseases 30 4 1998 363 369
26. F. Suter-Riniker, A. Berger, D. Mayor, P. Bittel, P. Iseli, and T. Bodmer Clinical significance of interleukin-2/gamma interferon ratios in Mycobacterium tuberculosis-specific T-cell signatures Clin Vaccine Immunol 18 8 2011 1395 1396
27. S.-j. Zhang, and H.-p. Xiao [Changes and significance of peripheral blood T cell subsets, soluble interleukin-2 receptor and interferon-gamma in patients with retreatment pulmonary tuberculosis and initial treatment tuberculosis] Chung Hua Chieh Ho Ho Hu Hsi Tsa Chih 34 12 2011 884 887
28. S. Bertholet, D.J. Horne, E.M. Laughlin, M. Savlov, I. Tucakovic, R.N. Coler, M. Narita, and S.G. Reed Effect of chemotherapy on whole-blood cytokine responses to Mycobacterium tuberculosis antigens in a small cohort of patients with pulmonary tuberculosis Clinical and Vaccine Immunology 18 8 2011 1378 1386
29. S. Bihari, N. Cavalcanti, J.B. Correia, G. Alves, E. Souza, B.J. Brabin, and L.E. Cuevas Interferon gamma-induced protein-10 concentrations in children with previous tuberculosis infections and disease Pediatr Infect Dis J 31 10 2012 1089 1091
30. S.-Y. Eum, Y.-J. Lee, J.-H. Min, H.-K. Kwak, M.-S. Hong, J.-H. Kong, S.-H. Hwang, S.-K. Park, J.J. Leblanc, L.E. Via, C.E. Barry 3rd, and S.-N. Cho Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis Respiration 80 4 2010 275 284
31. A. Harari, V. Rozot, F.B. Enders, M. Perreau, J.M. Stalder, L.P. Nicod, M. Cavassini, T. Calandra, C.L. Blanchet, K. Jaton, M. Faouzi, C.L. Day, W.A. Hanekom, P.-A. Bart, and G. Pantaleo Dominant TNF-+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease Nat Med 17 3 2011 372 376
32. B.S.A. Kabeer, A. Raja, B. Raman, S. Thangaraj, M. Leportier, G. Ippolito, E. Girardi, P.H. Lagrange, and D. Goletti IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy BMC Infectious Diseases 11 2011 135
33. C.H. Kim, K.J. Choi, S.S. Yoo, S.Y. Lee, D.I. Won, J.O. Lim, S.I. Cha, J.Y. Park, and J. Lee Comparative analysis of whole-blood interferon-gamma and flow cytometry assays for detecting post-treatment Immune responses in patients with active tuberculosis Cytometry B Clin Cytom 86 4 2014 236 243
34. A. Marchant, A. Amedei, A. Azzurri, J. Vekemans, M. Benagiano, C. Tamburini, C. Lienhardt, T. Corrah, K.P. McAdam, S. Romagnani, M.M. D'Elios, and G. Del Prete Polarization of PPD-specific T-cell response of patients with tuberculosis from Th0 to Th1 profile after successful antimycobacterial therapy or in vitro conditioning with interferon-alpha or interleukin-12 Am J Respir Cell Mol Biol 24 2 2001 187 194
35. A.M.M. Mattos, CdS. Almeida, K.L.M.C. Franken, CCdS. Alves, C. Abramo, M.A. de Souza, M. L'Hotellier, M.J.M. Alves, A.P. Ferreira, S.C. Oliveira, T.H.M. Ottenhoff, and H.C. Teixeira Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy Int Immunol 22 9 2010 775 782
36. K.A. Millington, J.A. Innes, S. Hackforth, T.S.C. Hinks, J.J. Deeks, D.P.S. Dosanjh, V. Guyot-Revol, R. Gunatheesan, P. Klenerman, and A. Lalvani Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load Journal of Immunology 178 8 2007 5217 5226
37. E.P. Moura, V.P.C.P. Toledo, M.H.P. Oliveira, S. Spindola-de-Miranda, H.M. Andrade, and T.M.P.D. Guimaraes Pulmonary tuberculosis: evaluation of interferon-gamma levels as an immunological healing marker based on the response to the Bacillus Calmette-Guerin Memorias do Instituto Oswaldo Cruz 99 3 2004 283 287
38. E. Petruccioli, L. Petrone, V. Vanini, A. Sampaolesi, G. Gualano, E. Girardi, F. Palmieri, and D. Goletti IFN/TNFalpha specific-cells and effector memory phenotype associate with active tuberculosis Journal of Infection 66 6 2013 475 486
39. V.H. Sai Priya, B. Anuradha, S. Latha Gaddam, S.E. Hasnain, K.J.R. Murthy, and V.L. Valluri In vitro levels of interleukin 10 (IL-10) and IL-12 in response to a recombinant 32-kilodalton antigen of Mycobacterium bovis BCG after treatment for tuberculosis Clin Vaccine Immunol 16 1 2009 111 115
40. U. Sester, M. Fousse, J. Dirks, U. Mack, A. Prasse, M. Singh, A. Lalvani, and M. Sester Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states PLoS ONE [Electronic Resource] 6 3 2011 e17813
41. A. Singh, A.B. Dey, A. Mohan, P.K. Sharma, and D.K. Mitra Foxp3+ regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-producing T cells PLoS ONE [Electronic Resource] 7 9 2012 e44728
42. C.H. Song, H.J. Kim, J.K. Park, J.H. Lim, U.O. Kim, J.S. Kim, T.H. Paik, K.J. Kim, J.W. Suhr, and E.K. Jo Depressed interleukin-12 (IL-12), but not IL-18, production in response to a 30- or 32-kilodalton mycobacterial antigen in patients with active pulmonary tuberculosis Infect Immun 68 8 2000 4477 4484
43. M. Torres, T. Herrera, H. Villareal, E.A. Rich, and E. Sada Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis Infect Immun 66 1 1998 176 180
44. J.M. Young, I.M.O. Adetifa, M.O.C. Ota, and J.S. Sutherland Expanded polyfunctional T cell response to mycobacterial antigens in TB disease and contraction post-treatment PLoS ONE [Electronic Resource] 5 6 2010 e11237
45. CdS. Almeida, C. Abramo, CCdS. Alves, L. Mazzoccoli, A.P. Ferreira, and H.C. Teixeira Anti-mycobacterial treatment reduces high plasma levels of CXC-chemokines detected in active tuberculosis by cytometric bead array Memorias do Instituto Oswaldo Cruz 104 7 2009 1039 1041
46. F. Ameglio, M. Casarini, E. Capoluongo, P. Mattia, G. Puglisi, and S. Giosue Post-treatment changes of six cytokines in active pulmonary tuberculosis: differences between patients with stable or increased fibrosis Int J Tuberc Lung Dis 9 1 2005 98 104
47. A. Azzurri, O.Y. Sow, A. Amedei, B. Bah, S. Diallo, G. Peri, M. Benagiano, M.M. D'Elios, A. Mantovani, and G. Del Prete IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection Microbes Infect 7 1 2005 1 8
48. L.G. Bekker, G. Maartens, L. Steyn, and G. Kaplan Selective increase in plasma tumor necrosis factor-alpha and concomitant clinical deterioration after initiating therapy in patients with severe tuberculosis Journal of Infectious Diseases 178 2 1998 580 584
49. T.P. da Silva, C.B.W. Giacoia-Gripp, C.A. Schmaltz, F.M. Sant' Anna, V. Rolla, and M.G. Morgado T Cell Activation and Cytokine Profile of Tuberculosis and HIV-Positive Individuals during Antituberculous Treatment and Efavirenz-Based Regimens PLoS ONE 8 6 2013
50. J.S. Friedland, J.C. Hartley, C.G. Hartley, R.J. Shattock, and G.E. Griffin Cytokine secretion in vivo and ex vivo following chemotherapy of Mycobacterium tuberculosis infection Trans R Soc Trop Med Hyg 90 2 1996 199 203
51. J.Y. Hong, H.J. Lee, S.Y. Kim, K.S. Chung, E.Y. Kim, J.Y. Jung, M.S. Park, Y.S. Kim, S.K. Kim, J. Chang, S.N. Cho, and Y.A. Kang Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment The Journal of infection 68 3 2014 252 258
52. N.P. Juffermans, A. Verbon, S.J. van Deventer, H. van Deutekom, P. Speelman, and T. van der Poll Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis Am J Respir Crit Care Med 157 4 Pt 1 1998 1328 1331
53. J.H. Lee, and J.H. Chang Changes of plasma interleukin-1 receptor antagonist, interleukin-8 and other serologic markers during chemotherapy in patients with active pulmonary tuberculosis Korean J Intern Med 18 3 2003 138 145
54. E. Peresi, S.M.U.R. Silva, S.A. Calvi, and J. Marcondes-Machado Cytokines and acute phase serum proteins as markers of inflammatory regression during the treatment of pulmonary tuberculosis J Bras Pneumol 34 11 2008 942 949
55. W.-L. Su, W.-C. Perng, C.-H. Huang, C.-Y. Yang, C.-P. Wu, and J.-H. Chen Association of reduced tumor necrosis factor alpha, gamma interferon, and interleukin-1beta (IL-1beta) but increased IL-10 expression with improved chest radiography in patients with pulmonary tuberculosis Clin Vaccine Immunol 17 2 2010 223 231
56. S. Tang, H. Xiao, Y. Fan, F. Wu, Z. Zhang, H. Li, and Y. Yang [Changes of proinflammatory cytokines and their receptors in serum from patients with pulmonary tuberculosis] Chung Hua Chieh Ho Ho Hu Hsi Tsa Chih 25 6 2002 325 329
57. A. Verbon, N. Juffermans, S.J. Van Deventer, P. Speelman, H. Van Deutekom, and T. Van Der Poll Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment Clin Exp Immunol 115 1 1999 110 113
58. J.Y. Wang, H.C. Chang, J.L. Liu, C.C. Shu, C.H. Lee, J.T. Wang, and L.N. Lee Expression of toll-like receptor 2 and plasma level of interleukin-10 are associated with outcome in tuberculosis Eur J Clin Microbiol Infect Dis 31 9 2012 2327 2333
59. J.Y. Wang, H.C. Chang, J.L. Liu, C.C. Shu, C.H. Lee, J.T. Wang, and L.N. Lee Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients Journal of Acquired Immune Deficiency Syndromes 39 3 2005 265 271
60. T. Chiacchio, E. Petruccioli, V. Vanini, O. Butera, G. Cuzzi, L. Petrone, G. Matteucci, F.N. Lauria, K.L.M.C. Franken, E. Girardi, T.H.M. Ottenhoff, and D. Goletti Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood PLoS ONE [Electronic Resource] 6 11 2011 e27539
61. K.A. Wilkinson, and R.J. Wilkinson Polyfunctional T cells in human tuberculosis European journal of immunology 40 8 2010 2139 2142
62. B.M. Kagina, B. Abel, T.J. Scriba, E.J. Hughes, A. Keyser, A. Soares, H. Gamieldien, M. Sidibana, M. Hatherill, S. Gelderbloem, H. Mahomed, A. Hawkridge, G. Hussey, G. Kaplan, and W.A. Hanekom Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns American journal of respiratory and critical care medicine 182 8 2010 1073 1079
63. N. Hagau, A. Slavcovici, D.N. Gonganau, S. Oltean, D.S. Dirzu, E.S. Brezoszki, M. Maxim, C. Ciuce, M. Mlesnite, R.L. Gavrus, C. Laslo, R. Hagau, M. Petrescu, and D.M. Studnicska Clinical aspects and cytokine response in severe H1N1 influenza A virus infection Critical care (London, England) 14 6 2010 R203
64. A. Waage, A. Halstensen, and T. Espevik Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease Lancet 1 8529 1987 355 357
65. P. Kragsbjerg, T. Vikerfors, and H. Holmberg Cytokine responses in patients with pneumonia caused by Chlamydia or Mycoplasma Respiration 65 4 1998 299 303