Polyfunctional T cells in human tuberculosis

European Journal of Immunology

Volumn 40, Issue 8, 2010, Pages 2139-2142

  Wilkinson, Katalin A ^a,b   Wilkinson, Robert J ^a,b,c  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Correlates of protection; Cytokines; HIV; Polyfunctional cells; Tuberculosis

Indexed keywords

CULTURE FILTRATE PROTEIN 10; CYTOKINE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR;

BACTERIAL IMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE RELEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTE PROLIFERATION; MIXED INFECTION; MYCOBACTERIUM TUBERCULOSIS; NOTE; PRIORITY JOURNAL; T LYMPHOCYTE; TUBERCULOSIS;

ANIMALS; ANTIGENS, BACTERIAL; CD4-POSITIVE T-LYMPHOCYTES; CLINICAL TRIALS AS TOPIC; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS, PULMONARY;

EID: 77956110338     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040731     Document Type: Note

References (24)

1. Hamann, D., Baars, P. A., Rep, M. H., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R. and van Lier, R. A., Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 1997. 186: 1407-1418.
2. Sallusto, F., Geginat, J. and Lanzavecchia, A., Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 2004. 22: 745-763.
3. Appay, V., van Lier, R. A., Sallusto, F. and Roederer, M., Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 2008. 73: 975-983.
4. Appay, V., Dunbar, P. R., Callan, M., Klenerman, P., Gillespie, G. M., Papagno, L., Ogg, G. S. et al., Memory CD81 T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002. 8: 379-385.
5. Harari, A., Vallelian, F., Meylan, P. R. and Pantaleo, G., Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J. Immunol. 2005. 174: 1037-1045.
6. Klenerman, P. and Hill, A., T cells and viral persistence: lessons from diverse infections. Nat. Immunol. 2005. 6: 873-879.
7. Harari, A., Dutoit, V., Cellerai, C., Bart, P. A., Du Pasquier, R. A. and Pantaleo, G., Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol. Rev. 2006. 211: 236-254.
8. Harari, A., Petitpierre, S., Vallelian, F. and Pantaleo, G., Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood 2004. 103: 966-972.
9. Owen, R. E., Heitman, J.W., Hirschkorn, D. F., Lanteri,M. C., Biswas, H. H., Martin, J. N., Krone, M. R. et al., HIV1 elite controllers have low HIVspecific T-cell activation yet maintain strong, polyfunctional T-cell responses. Aids 2010. 24: 1095-1105.
10. Beveridge, N. E., Price, D. A., Casazza, J. P., Pathan, A. A., Sander, C. R., Asher, T. E., Ambrozak, D. R. et al., Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD41 memory T lymphocyte populations. Eur. J. Immunol. 2007. 37: 3089-3100.
11. Scriba, T. J., Tameris, M., Mansoor, N., Smit, E., van der Merwe, L., Isaacs, F., Keyser, A. et al., Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD41 T cells. Eur. J. Immunol. 2010. 40: 279-290.
12. Abel, B., Tameris, M., Mansoor, N., Gelderbloem, S., Hughes, J., Abrahams, D., Makhethe, L. et al., The Novel TB Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4 and CD8 T Cells in Adults. Am J. Respir. Crit. Care. Med. 2010. 181: 1407-1417.
13. Soares, A. P., Scriba, T. J., Joseph, S., Harbacheuski, R., Murray, R. A., Gelderbloem, S. J., Hawkridge, A. et al., Bacillus calmette-guerin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J. Immunol. 2008. 180: 3569-3577.
14. Day, C. L., Mkhwanazi, N., Reddy, S., Mncube, Z., van der Stok, M., Klenerman, P. and Walker, B. D., Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. J. Infect. Dis. 2008. 197: 990-999.
15. Millington, K. A., Innes, J. A., Hackforth, S., Hinks, T. S., Deeks, J. J., Dosanjh, D. P., Guyot-Revol, V. et al., Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. J. Immunol 2007. 178: 5217-5226.
16. Darrah, P. A., Patel, D. T., De Luca, P. M., Lindsay, R. W., Davey, D. F., Flynn, B. J., Hoff, S. T. et al., Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 2007. 13: 843-850.
17. Forbes, E. K., Sander, C., Ronan, E. O., McShane, H., Hill, A. V., Beverley, P. C. and Tchilian, E. Z., Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice. J. Immunol. 2008. 181: 4955-4964.
18. Caccamo, N., Guggino, G., Joosten, S. A., Gelsomino, G., Di Carlo, P., Titone, L., Galati, D., Bocchino, M. et al., Multifunctional CD41 T cells correllate with active Mycobacterium tuberculosis infection. Eur. J. Immunol. 2010. 40: 2211-2220.
19. Sutherland, J. S., Adetifa, I. M., Hill, P. C., Adegbola, R. A. and Ota, M. O., Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur. J. Immunol. 2009. 39: 723-729.
20. Wilkinson, K. A., Wilkinson, R. J., Pathan, A., Ewer, K., Prakash, M., Klenerman, P., Maskell, N. et al., Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. Clin. Infect. Dis. 2005. 40: 184-187.
21. Kalsdorf, B., Scriba, T. J., Wood, K., Day, C. L., Dheda, K., Dawson, R., Hanekom,W. A. et al., HIV-1 Infection Impairs the Bronchoalveolar T Cell Response to Mycobacteria. Am. J. Respir. Crit. Care Med. 2009. 180: 1262-1270.
22. Barry C. E. 3rd., Boshoff, H. I., Dartois, V., Dick, T., Ehrt, S., Flynn, J., Schnappinger, D. et al., The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat. Rev. Microbiol. 2009. 7: 845-855.
23. Wilkinson, K. A., Seldon, R., Meintjes, G., Rangaka, M. X., Hanekom, W. A., Maartens, G. andWilkinson, R. J., Dissection of regenerating T cell responses against tuberculosis in HIV infected adults with latent tuberculosis. Am. J. Respir. Crit. Care Med. 2009. 180: 674-683.
24. Sutherland, J. S., Young, J. M., Peterson, K. L., Sanneh, B., Whittle, H. C., Rowland-Jones, S. L., Adegbola, R. A. et al., Polyfunctional CD4(1) and CD8(1) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment. J. Immunol. 2010. 184: 6537-6544.