Increased IgG1, IFN-γ, TNF-α and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy

International Immunology

Volumn 22, Issue 9, 2010, Pages 775-782

  Mattos, Ana Márcia M ^a   de Almeida, Caroline S ^a   Franken, Kees L M C ^b   de Alves, Caio César S ^a   Abramo, Clarice ^a   de Souza, Maria Aparecida ^a   L'Hotellier, Marcos ^c   Alves, Márcio J M ^a   Ferreira, Ana Paula ^a   Oliveira, Sérgio C ^d   Ottenhoff, Tom H M ^b   Teixeira, Henrique C ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Respiratory Diseases Division   (Brazil)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Antibody response; Chemotherapy; Cytokines; ESAT 6 CFP 10; Tuberculosis

Indexed keywords

EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; ISONIAZID; MYCOBACTERIUM ANTIGEN; PYRAZINAMIDE; RIFAMPICIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; LUNG TUBERCULOSIS; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTIGENS, BACTERIAL; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-6; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956131187     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq429     Document Type: Article

References (46)

1. WHO. 2009. Global tuberculosis control: a short update to the 2009 report. WHO Press, Geneve.
2. Pilheu, J.A. 1998. Tuberculosis 2000: problems and solutions. Int. J. Tuberc. Lung Dis. 2:696.
3. American Thoracic Society, Center for Disease Control and Prevention. 2000. Diagnostic standards and classification of tuberculosis in adults and children. Am. J. Respir. Crit. Care Med. 161:1376.
4. Teixeira, H.C., Abramo, C. and Munk, M.E. 2007. Immunological diagnosis of tuberculosis: problems and strategies for success. J. Bras. Pneumol. 33:323.
5. Steingart, K.R., Ramsay, A. and Pai, M. 2007. Commercial serological tests for the diagnosis of tuberculosis: do they work? Future Microbiol. 2:355.
6. Abebe, F., Holm-Hansen, C., Wiker, H.G. and Bjune, G. 2007. Progress in serodiagnosis of Mycobacterium tuberculosis infection. Scand. J. Immunol. 66:176.
7. Chiang, I.H., Suo, J., Bai, K.J. et al. 1997. Serodiagnosis of tuberculosis. A study comparing three specific mycobacterial antigens. Am. J. Respir. Crit. Care Med. 156:906.
8. Wang, B.L., Xu, Y., Li, Z.M., Xu, Y.M., Weng, X.H. and Wang, H.H. 2005. Antibody response to four secretory proteins from Mycobacterium tuberculosis and their complex antigen in TB patients. Int. J. Tuberc. Lung Dis. 9:1327.
9. Arend, S.M., Andersen, P., Van Meijgaarden, K.E. et al. 2000. Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. J. Infect. Dis. 181:1850.
10. Abramo, C., Meijgaarden, K.E., Garcia, D. et al. 2006. Monokine induced by interferon gamma and IFN-γ response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients. Microbes Infect. 8:45.
11. Mahairas, G.G., Sabo, P.J., Hickey, M.J., Singh, D.C. and Stover, C.K. 1996. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J. Bacteriol. 178:1274.
12. Goletti, D., Carrara, S., Vicenti, D. et al. 2006. Accuracy of an immune diagnostic assay based on RD1 selected epitopes for active tuberculosis in a clinical setting: a pilot study. Clin. Microbiol. Infect. 12:544.
13. Van Pinxteren, L.A.H., Ravn, P., Agger, E.M., Pollock, J. and Andersen, P. 2000. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP-10. Clin. Diagn. Lab. Immunol. 7:155.
14. Kanunfre, K.A., Leite, O.H.M., Lopes, M.I., Litvoc, M. and Ferreira, A.W. 2008. Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis. Clin. Vaccine Immunol. 15:1028.
15. Schuck, S.D., Mueller, H., Kunitz, F. et al. 2009. Identification of T-cell antigens specific for latent Mycobacterium tuberculosis infection. PLoS One 4:e5590.
16. Demissie, A., Leyten, E.M.S., Abebe, M. et al. 2006. Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. Clin. Vaccine Immunol. 13:179.
17. Raja, A., Uma Devi, K.R., Amalingam, B. and Brennan, P.J. 2002. Immunoglobulin G, A, and M responses in serum and circulating immune complexes elicited by the 16-kilodalton antigen of Mycobacterium tuberculosis. Clin. Diagn. Lab. Immunol. 9:308.
18. Bafica, A., Scanga, C.A., Feng, C.G., Leifer, C., Cheever, A. and Sher, A. 2005. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacteria tuberculosis. J. Exp. Med. 202:1715.
19. Imanishi, T., Hara, H., Suzuki, S., Suzuki, N., Akira, S. and Saito, T. 2007. TLR2 directly triggers Th1 effector functions. J. Immunol. 178:6715.
20. Sahiratmadja, E., Alisjahbana, B., De Boer, T. et al. 2007. Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment. Infect. Immun. 75:820.
21. Kursar, M., Koch, M., Mittrücker, H. W. et al. 2007. Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J. Immunol. 178:2661.
22. Cooper, A.M. 2009. Cell-mediated immune responses in Tuberculosis. Annu. Rev. Immunol. 27:393.
23. Finkelman, F.D., Holmes, J., Katona, I.M. et al. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol 8:303.
24. Hussain, R., Dawood, G., Abrar, N. et al. 1995. Selective increases in antibody isotypes and immunoglobulin G subclass responses to secreted antigens in tuberculosis patients and healthy household contacts of the patients. Clin. Diagn. Lab. Immunol 2:726.
25. Fanger, M.W. and Guyre, P.M. 1991. Bispecific antibodies for targeted cellular cytotoxicity. Trends. Biotechnol. 11:375.
26. Franken, K.L., Hiemstra, H.S., van Meijgaarden, K.E., Subronto, Y., den Hartigh, J., Ottenhoff, T.H. and Drijfhout, J.W. 2000. Purification of histagged proteins by immobilized chelate affinity 782 IgG and cytokine responses in human TB chromatography: the benefits from the use of organic solvent. Protein Expr. Purif. 18:95.
27. Lyashchenko, K., Colangeli, R., Houde, M., Jahdali, H.A., Menzies, D. and Gennaro, M.L. 1998. Heterogeneous antibody responses in tuberculosis. Infect. Immun. 66:3936.
28. Imaz, M.S., Comini, M.A., Zerbini, E. et al. 2001. Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis. Int. J. Tuberc. Lung Dis. 5:1036.
29. Greenaway, C., Lienhardt, C., Adegbola, R., Brusasca, P., Mcadam, K. and Menzies, D. 2005. Humoral responses to Mycobacterium tuberculosis antigens in patients with tuberculosis in the Gambia. Int. J. Tuberc. Lung Dis. 9:1112.
30. Hoff, S.T., Abebe, M., Ravn, P. et al. 2007. Evaluation of Mycobacterium tuberculosis-specific antibody responses in populations with different levels of exposure from Tanzania, Ethiopia, Brazil and Denmark. Clin. Infect. Dis. 45:575.
31. Julián, E., Matas, L., Alcaide, J. and Luquin, M. 2004. Comparison of antibody responses to a potential combination of specific glycolipids and proteins for test sensitivity improvement in tuberculosis serodiagnosis. Clin. Diagn. Lab. Immunol. 11:70.
32. Yuan, Y., Crane, D.D. and Barry, C.E. 1996. Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial a-crystallin homolog. J. Bacteriol. 178:4484.
33. Imaz, M.S. and Zerbini, E. 2000. Antibody response to culture filtrate antigens of Mycobacterium tuberculosis during and after treatment of tuberculosis patients. Int. J. Tuberc. Lung Dis. 4:562.
34. Gupta, S., Shende, N., Bhatia, A.S., Kumar, S. and Harinath, B.C. 2005. IgG subclass antibody response to mycobacterial serine protease at different stages of pulmonary tuberculosis. Med. Sci. Monit. 11:585.
35. De Vallière, S., Abate, G., Blazevic, A., Heuertz, R.M. and Hoft, D.F. 2005. Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies. Infect. Immun. 73:6711.
36. Hussain, R., Shiratsuchi, H., Phillips, M., Ellner, J. and Wallis, R.S. 2001. Opsonizing antibodies (IgG1) up-regulate monocyte proin-flammatory cytokines tumour necrosis factor-alpha (TNF-α) and IL-6 but not anti-inflammatory cytokine IL-10 in mycobacterial antigen-stimulated monocytes-implications for pathogenesis. Clin. Exp. Immunol. 123:210.
37. Kawano, Y., Noma, T. and Yata, J. 1994. Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J. Immunol. 153:4948.
38. Abebe, F. and Bjune, G. 2009. The protective role of antibody responses during Mycobacterium tuberculosis infection. Clin. Exp. Immunol. 157:235.
39. Higgins, D.M., Sanchez-Campillo, J., Rosas-Taraco, A.G., Lee, E.J., Orme, I.M. and Gonzalez-Juarrero, M. 2009. Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection. Tuberculosis 89:149.
40. Almeida, C.S., Abramo, C., Alves, C.C.S., Mazzoccoli, L., Ferreira, A.P. and Teixeira, H.C. 2009. Anti-mycobacterial treatment reduces high plasma levels of CXC-chemokines detected in active tuberculosis by cytometric bead array. Mem. Inst. Oswaldo Cruz 104:1039.
41. Djoba Siawaya, J.F., Beyers, N., van Helden, P. and Walzl, G. 2009. Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis. Clin. Exp. Immunol. 156:69.
42. Ribeiro-Rodrigues, R., Resende, Co, T., Johnson, J.L. et al. 2002. Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance. Clin. Diagn. Lab. Immunol. 9:818.
43. Nicol, M.P., Pienaar, D., Wood, K. et al. 2005. Enzyme-linked immunospot assay responses to early secretory antigenic target 6, culture filtrate protein 10, and purified protein derivative among children with tuberculosis: implications for diagnosis and monitoring of therapy. Clin. Infect. Dis. 40:1301.
44. Rook, G.A., Hernandez-Pando, R., Dheda, K. and Teng Seah, G. 2004. IL-4 in tuberculosis: implications for vaccine design. Trends Immunol. 25:483.
45. Szabo, S.J., Dighe, A.S., Gubler, U. and Murphy, K. 1997. Regulation of the interleukin (IL)-12R2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
46. Elser, B., Lohoff, M., Kock, S. et al. 2002. IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity 17:703.