Exploring the origin and limitations of kidney regeneration

Journal of Pathology

Volumn 236, Issue 2, 2015, Pages 251-263

  Endo, Tomomi ^a,b   Nakamura, Jin ^a   Sato, Yuki ^a   Asada, Misako ^a   Yamada, Ryo ^a   Takase, Masayuki ^a,c   Takaori, Koji ^a   Oguchi, Akiko ^a   Iguchi, Taku ^a,c   Higashi, Atsuko Y ^d   Ohbayashi, Tetsuya ^e   Nakamura, Tomoyuki ^d   Muso, Eri ^b   Kimura, Takeshi ^a   Yanagita, Motoko ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Kitano Hospital   (Japan)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^d KANSAI MEDICAL UNIVERSITY   (Japan)

^e TOTTORI UNIVERSITY   (Japan)

Author keywords

acute kidney injury; chronic kidney disease; fibrosis; nephron; regeneration; tubule

Indexed keywords

CALBINDIN 1; CRE RECOMBINASE; MESSENGER RNA; CELL CYCLE PROTEIN; N-MYC DOWNSTREAM-REGULATED GENE 1 PROTEIN; SIGNAL PEPTIDE;

ACUTE KIDNEY FAILURE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX ATROPHY; CELL POPULATION; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; FIBROSING ALVEOLITIS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY CORTEX; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TISSUE REGENERATION; TISSUE REPAIR; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; FIBROSIS; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION;

ACUTE KIDNEY INJURY; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; FIBROSIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; KIDNEY TUBULES, PROXIMAL; MICE, INBRED C57BL; MICE, TRANSGENIC; REGENERATION;

EID: 84929274170     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4514     Document Type: Article

References (61)

1. Thadhani R, Pascual M, Bonventre JV,. Acute renal failure. N Engl J Med 1996; 334: 1448-1460.
2. Dennen P, Douglas IS, Anderson R,. Acute kidney injury in the intensive care unit: an update and primer for the intensivist. Crit Care Med 2010; 38: 261-275.
3. Chertow GM, Burdick E, Honour M, et al., Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16: 3365-3370.
4. Lewington AJ, Cerda J, Mehta RL,. Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int 2013; 84: 457-467.
5. Bonventre JV, Basile D, Liu KD, et al., AKI: a path forward. Clin J Am Soc Nephrol 2013; 8: 1606-1608.
6. McCampbell KK, Wingert RA,. Renal stem cells: fact or science fiction? Biochem J 2012; 444: 153-168.
7. Reule S, Gupta S,. Kidney regeneration and resident stem cells. Organogenesis 2011; 7: 135-139.
8. Duffield JS, Humphreys BD,. Origin of new cells in the adult kidney: results from genetic labeling techniques. Kidney Int 2011; 79: 494-501.
9. Little MH, Bertram JF,. Is there such a thing as a renal stem cell? J Am Soc Nephrol 2009; 20: 2112-2117.
10. Vogetseder A, Palan T, Bacic D, et al., Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. Am J Physiol Cell Physiol 2007; 292: C807-C813.
11. Vogetseder A, Picard N, Gaspert A, et al., Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells. Am J Physiol Cell Physiol 2008; 294: C22-C28.
12. Sagrinati C, Netti GS, Mazzinghi B, et al., Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 2006; 17: 2443-2456.
13. Appel D, Kershaw DB, Smeets B, et al., Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 2009; 20: 333-343.
14. Ronconi E, Sagrinati C, Angelotti ML, et al., Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 2009; 20: 322-332.
15. Kitamura S, Yamasaki Y, Kinomura M, et al., Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney. FASEB J 2005; 19: 1789-1797.
16. Maeshima A, Yamashita S, Nojima Y,. Identification of renal progenitor-like tubular cells that participate in the regeneration processes of the kidney. J Am Soc Nephrol 2003; 14: 3138-3146.
17. Challen GA, Bertoncello I, Deane JA, et al., Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity. J Am Soc Nephrol 2006; 17: 1896-1912.
18. Langworthy M, Zhou B, de Caestecker M, et al., NFATc1 identifies a population of proximal tubule cell progenitors. J Am Soc Nephrol 2009; 20: 311-321.
19. Gupta S, Verfaillie C, Chmielewski D, et al., Isolation and characterization of kidney-derived stem cells. J Am Soc Nephrol 2006; 17: 3028-3040.
20. Kobayashi A, Valerius MT, Mugford JW, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008; 3: 169-181.
21. Humphreys BD, Valerius MT, Kobayashi A, et al., Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2: 284-291.
22. Lachat P, Shaw P, Gebhard S, et al., Expression of NDRG1, a differentiation-related gene, in human tissues. Histochem Cell Biol 2002; 118: 399-408.
23. Okuda T, Higashi Y, Kokame K, et al., Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol 2004; 24: 3949-3956.
24. Seibler J, Zevnik B, Kuter-Luks B, et al., Rapid generation of inducible mouse mutants. Nucleic Acids Res 2003; 31: e12.
25. Kusaba T, Lalli M, Kramann R, et al., Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A 2014; 111: 1527-1532.
26. Berger K, Bangen JM, Hammerich L, et al., Origin of regenerating tubular cells after acute kidney injury. Proc Natl Acad Sci U S A 2014; 111: 1533-1538.
27. Coca SG, Singanamala S, Parikh CR,. Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int 2012; 81: 442-448.
28. James MT, Hemmelgarn BR, Wiebe N, et al., Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study. Lancet 2010; 376: 2096-2103.
29. Lo LJ, Go AS, Chertow GM, et al., Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int 2009; 76: 893-899.
30. Sanoff S, Okusa MD,. Impact of acute kidney injury on chronic kidney disease and its progression. Contrib Nephro 2011; 171: 213-217.
31. Ishani A, Xue JL, Himmelfarb J, et al., Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 2009; 20: 223-228.
32. Goldstein SL, Jaber BL, Faubel S, et al., AKI transition of care: a potential opportunity to detect and prevent CKD. Clin J Am Soc Nephrol 2013; 8: 476-483.
33. Chawla LS, Kimmel PL,. Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int 2012; 82: 516-524.
34. Bucaloiu ID, Kirchner HL, Norfolk ER, et al., Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int 2012; 81: 477-485.
35. Hebert LA, Agarwal G, Sedmak DD, et al., Proximal tubular epithelial hyperplasia in patients with chronic glomerular proteinuria. Kidney Int 2000; 57: 1962-1967.
36. Shimono A, Okuda T, Kondoh H,. N-myc-dependent repression of Ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech Dev 1999; 83: 39-52.
37. Higashi AY, Ikawa T, Muramatsu M, et al., Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J Immunol 2009; 182: 5633-5640.
38. Srinivas S, Watanabe T, Lin CS, et al., Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 2001; 1: 4.
39. Soriano P., Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet 1999; 21: 70-71.
40. Tanaka M, Endo S, Okuda T, et al., Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int 2008; 73: 181-191.
41. Oliver JA, Maarouf O, Cheema FH, et al., The renal papilla is a niche for adult kidney stem cells. J Clin Invest 2004; 114: 795-804.
42. Yanagita M, Arai H, Nakano T, et al., Gas6 induces mesangial cell proliferation via latent transcription factor STAT3. J Biol Chem 2001; 276: 42364-42369.
43. Yanagita M, Okuda T, Endo S, et al., Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury. J Clin Invest 2006; 116: 70-79.
44. Asada N, Takase M, Nakamura J, et al., Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest 2011; 121: 3981-3990.
45. Tanaka T, Miyata T, Inagi R, et al., Hypoxia in renal disease with proteinuria and/or glomerular hypertension. Am J Pathol 2004; 165: 1979-1992.
46. Forbes MS, Thornhill BA, Chevalier RL,. Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model. Am J Physiol Renal Physiol. 2011; 301: F110-F117.
47. Thornhill BA, Forbes MS, Marcinko ES, et al., Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction. Kidney Int 2007; 72: 1103-1112.
48. Pagtalunan ME, Olson JL, Tilney NL, et al., Late consequences of acute ischemic injury to a solitary kidney. J Am Soc Nephrol 1999; 10: 366-373.
49. Wakisaka Y, Furuta A, Masuda K, et al., Cellular distribution of NDRG1 protein in the rat kidney and brain during normal postnatal development. J Histochem Cytochem 2003; 51: 1515-1525.
50. Kazama I, Mahoney Z, Miner JH, et al., Podocyte-derived BMP7 is critical for nephron development. J Am Soc Nephrol 2008; 19: 2181-2191.
51. Nakhoul N, Batuman V,. Role of proximal tubules in the pathogenesis of kidney disease. Contrib Nephrol 2011; 169: 37-50.
52. Kohan DE,. Progress in gene targeting: using mutant mice to study renal function and disease. Kidney Int 2008; 74: 427-437.
53. Little MH,. Tracing the life of the kidney tubule-re-establishing dogma and redirecting the options. Cell Stem Cell 2008; 2: 191-192.
54. Lindgren D, Bostrom AK, Nilsson K, et al., Isolation and characterization of progenitor-like cells from human renal proximal tubules. Am J Pathol 2011; 178: 828-837.
55. Angelotti ML, Ronconi E, Ballerini L, et al., Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells 2012; 30: 1714-1725.
56. Loverre A, Capobianco C, Ditonno P, et al., Increase of proliferating renal progenitor cells in acute tubular necrosis underlying delayed graft function. Transplantation 2008; 85: 1112-1119.
57. Barker N, Rookmaaker MB, Kujala P, et al., Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep 2012; 2: 540-552.
58. Smeets B, Boor P, Dijkman H, et al., Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration. J Pathol 2013; 229: 645-659.
59. Welling LW, Linshaw MA,. Structural and functional development of outer versus inner cortical proximal tubules. Pediatr Nephrol 1988; 2: 108-114.
60. Little MH, McMahon AP,. Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol 2012; 4.
61. Ishani A, Nelson D, Clothier B, et al., The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch Intern Med 2011; 171: 226-233.