RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response

Cell Reports

Volumn 11, Issue 2, 2015, Pages 192-200

  Takashima, Ken ^a   Oshiumi, Hiroyuki ^a   Takaki, Hiromi ^a   Matsumoto, Misako ^a   Seya, Tsukasa ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 3; MDA5 PROTEIN; PEPTIDES AND PROTEINS; PROTEIN KINASE; RIO KINASE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DEAD BOX PROTEIN; DOUBLE STRANDED RNA; IFIH1 PROTEIN, HUMAN; INTERFERON; PROTEIN SERINE THREONINE KINASE; RIO KINASE 3, HUMAN; VIRUS RNA;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; GENETICS; HEK293 CELL LINE; MEASLES; MEASLES VIRUS; MUTATION; PATHOGENICITY; PHOSPHORYLATION; VIROLOGY;

MEASLES VIRUS;

DEAD-BOX RNA HELICASES; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; MEASLES; MEASLES VIRUS; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, DOUBLE-STRANDED; RNA, VIRAL;

EID: 84929273566     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.03.027     Document Type: Article

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