Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: Involvement of Ca2+/calmodulin binding sites

Molecules and Cells

Volumn 37, Issue 9, 2014, Pages 656-663

  Choi, Sun Hye ^a   Lee, Byung Hwan ^a   Kim, Hyeon Joong ^a   Jung, Seok Won ^a   Kim, Hyun Sook ^a   Shin, Ho Chul ^a   Lee, Jun Hee ^b   Kim, Hyoung Chun ^c   Rhim, Hyewhon ^d   Hwang, Sung Hee ^e   Ha, Tal Soo ^f   Kim, Hyun Ji ^g   Cho, Hana ^g   Nah, Seung Yeol ^a  

^a Konkuk University   (South Korea)

^b Chongju University   (South Korea)

^c Kangwon National University   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Sangji University   (South Korea)

^f Daegu University   (South Korea)

^g Samsung Medical Center   (South Korea)

Author keywords

Ginseng; Gintonin; Heart; IKs channel; LPA receptor

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; CALCIUM ION; CALMIDAZOLIUM; CALMODULIN; DELAYED RECTIFIER POTASSIUM CHANNEL; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GINTONIN; PLANT MEDICINAL PRODUCT; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; 3-(4-(4-((1-(2-CHLOROPHENYL)ETHOXY)CARBONYL AMINO)-3-METHYL-5-ISOXAZOLYL) BENZYLSULFANYL) PROPANOIC ACID; CALCIUM; ISOXAZOLE DERIVATIVE; KCNQ1 PROTEIN, HUMAN; LYSOPHOSPHATIDIC ACID RECEPTOR; MLP151 PROTEIN, PANAX GINSENG; PROPIONIC ACID DERIVATIVE; VEGETABLE PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CARDIAC MUSCLE CELL; CONTROLLED STUDY; EC50; ELECTRIC POTENTIAL; GENE EXPRESSION SYSTEM; GINSENG; GUINEA PIG; NONHUMAN; STEADY STATE; UPREGULATION; ANIMAL; CALCIUM SIGNALING; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE CELL; HUMAN; METABOLISM; OOCYTE; PANAX; PHYSIOLOGY; XENOPUS LAEVIS;

ANIMALS; BINDING SITES; CALCIUM; CALCIUM SIGNALING; CALMODULIN; DELAYED RECTIFIER POTASSIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GUINEA PIGS; HUMANS; ISOXAZOLES; KCNQ1 POTASSIUM CHANNEL; MYOCYTES, CARDIAC; OOCYTES; PANAX; PLANT PROTEINS; PROPIONATES; RECEPTORS, LYSOPHOSPHATIDIC ACID; XENOPUS LAEVIS;

EID: 84929260573     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2014.0087     Document Type: Article

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