Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: Involvement of tyrosine kinase and receptor protein tyrosine phosphatase α

Neuroscience Letters

Volumn 548, Issue , 2013, Pages 143-148

  Lee, Jun Ho ^a   Choi, Sun Hye ^a   Lee, Byung Hwan ^a   Hwang, Sung Hee ^a   Kim, Hyeon Joong ^a   Rhee, Jeehae ^a   Chung, ChiHye ^a   Nah, Seung Yeol ^a  

^a Konkuk University   (South Korea)

Author keywords

Ginseng; Gintonin; LPA receptor; Potassium channel; Receptor protein tyrosine phosphatase ; Tyrosine kinase

Indexed keywords

CHELATING AGENT; GENISTEIN; GINSENG EXTRACT; GINTONIN; LYSOPHOSPHATIDIC ACID RECEPTOR; PHOSPHOLIPASE C INHIBITOR; POTASSIUM CHANNEL KV1.2; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RECEPTOR BLOCKING AGENT; RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA; RNA; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; XENOPUS;

G-PROTEIN COUPLED RECEPTOR; GINSENG; GINTONIN; GPCR; GT; LPA RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR; POTASSIUM CHANNEL; RECEPTOR PROTEIN TYROSINE PHOSPHATASE Α; RPTP ALPHA; TYROSINE KINASE; TYROSINE PHOSPHATASE ALPHA;

ANIMALS; ION CHANNEL GATING; KV1.2 POTASSIUM CHANNEL; MULTIENZYME COMPLEXES; OOCYTES; PANAX; PLANT EXTRACTS; PROTEIN-TYROSINE KINASES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, LYSOPHOSPHATIDIC ACID; XENOPUS LAEVIS;

EID: 84880133701     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.05.048     Document Type: Article

References (21)

1. Castilla-Ortega E., Hoyo-Becerra C., Pedraza C., Chun J., Rodríguez De Fonseca F., Estivill-Torrús G., Santín L.J. Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA receptor knockout mice. PLoS One 2011, 6(9):e25522.
2. 1 receptor channel currents. Mol. Cells 2013, 35(2):142-150.
3. Dodson P.D., Billups B., Rusznak Z., Szucs G., Barker M.C., Forsythe I.D. Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion. J. Physiol. 2003, 550(1):27-33.
4. Dubin A.E., Bahnson T., Weiner J.A., Fukushima N., Chun J. Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. J. Neurosci. 1999, 19(4):1371-1381.
5. Dubin A.E., Herr D.R., Chun J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J. Neurosci. 2010, 30(21):7300-7309.
6. Grosse G., Draguhn A., Hohne L., Tapp R., Veh R.W., Ahnert-Hilger G. Expression of Kv1 potassium channels in mouse hippocampal primary cultures: development and activity-dependent regulation. J. Neurosci. 2000, 20(5):1869-1882.
7. Hille B. Ion Channels of Excitable Membranes 2001, 814. Sinauer Associates Inc., Sunderland, MA.
8. Hwang S.H., Shin T.J., Choi S.H., Cho H.J., Lee B.H., Pyo M.K., Lee J.H., Kang J., Kim H.J., Park C.W., Shin H.C., Nah S.Y. Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Mol. Cells 2012, 33(2):151-162.
9. Hwang S.H., Shin T.J., Choi S.H., Cho H.J., Lee B.H., Pyo M.K., Lee J.H., Kang J., Kim H.J., Park C.W., Shin H.C., Nah S.Y. Gintonin newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Mol. Cells 2012, 33(2):151-162.
10. Huang X.Y., Morielli A.D., Peralta E.G. Tyrosine kinase dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor. Cell 1993, 75(6):1145-1156.
11. Imbrici P., Tucker S.J., D'Adamo M.C., Pessia M. Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels. Pfluge Arch. 2000, 441(2-3):257-262.
12. Kimura Y., Schmitt A., Fukushima N., Ishii I., Kimura H., Nebreda A.R., Chun J. Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J. Biol. Chem. 2001, 276(18):15208-15215.
13. Lee J.H., Shin E.J., Jeong S.M., Lee B.H., Yoon I.S., Lee J.H., Choi S.H., Kim Y.H., Pyo M.K., Lee S.M., Chae J.S., Rhim H., Oh J.W., Kim H.C., Nah S.Y. Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes. Eur. J. Pharmacol. 2007, 564(1-3):7-17.
14. Matas-Rico E., García-Diaz B., Llebrez-Zayas P., López-Barroso D., Santín L., Pedraza C., Smith-Fernández A., Fernández-Llebrez P., Tellez T., Redondo M., Chun J., De Fonseca F.R., Estivill-Torrús G. Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol. Cell. Neurosci. 2008, 39(3):342-355.
15. Nah S.Y., Kim D.H., Rhim H. Ginsenosides: are any of them candidates for drugs acting on the central nervous system?. CNS Drug Rev. 2007, 13(4):381-404.
16. Nah S.Y., Gintonin A novel ginseng-derived ligand that targets g protein-coupled lysophosphatidic acid receptors. Curr. Drug Targets 2012, 13(13):1659-1664.
17. Ohta H., Sato K., Murata N., Damirin A., Malchinkhuu E., Kon J., Kimura T., Tobo M., Yamazaki Y., Watanabe T. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol. Pharmacol. 2003, 64(4):994-1005.
18. Pyo M.K., Choi S.H., Hwang S.H., Shin T.J., Lee B.H., Lee S.M., Lim Y., Kim D., Nah S.Y. Novel glycoproteins from ginseng. J. Gingseng Res. 2011, 35(1):92-103.
19. Shin T.J., Kim H.J., Kwon B.J., Choi S.H., Kim H.B., Hwang S.H., Lee B.H., Lee S.M., Zukin R.S., Park J.H., Kim H.C., Rhim H., Lee J.H., Nah S.Y. Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-d-aspartic acid receptor activation: involvement of LPA receptors. Mol. Cells 2012, 34(6):563-572.
20. Tsai W., Morielli A.D., Cachero T.G., Peralta E.G. Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity. EMBO J. 1999, 18(1):109-118.
21. Veloso A., Fernández R., Astigarraga E., Barreda-Gómez G., Manuel I., Giralt M.T., Ferrer I., Ochoa B., Rodríguez-Puertas R., Fernández J.A. Distribution of lipids in human brain. Anal. Bioanal. Chem. 2011, 401(1):89-101.