Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type Ca2+ channel current inhibitions

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 7, 2009, Pages 1224-1230

  Choi, Sun Hye ^a   Lee, Jun Ho ^a   Pyo, Mi Kyung ^a   Lee, Byung Hwan ^a   Shin, Tae Joon ^a   Hwang, Sung Hee ^a   Kim, Bo Ra ^a   Lee, Sang Mok ^a   Oh, Jae Wook ^b   Kim, Hyoung Chun ^c   Bae, Chun Sik ^d   Rhim, Hyewhon ^e   Nah, Seung Yeol ^a  

^a Konkuk University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Kangwon National University   (South Korea)

^d Chonnam National University   (South Korea)

^e Korea Institute of Science and Technology   (South Korea)

Author keywords

Ginsenoside Rg3; L type Ca2+ channel; Panax ginseng; Site directed mutation

Indexed keywords

ASPARAGINE; CALCIUM CHANNEL L TYPE; GINSENOSIDE RG 3; LEUCINE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; MICROELECTRODE; NONHUMAN; OOCYTE; POINT MUTATION; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; STEADY STATE; VOLTAGE CLAMP; WILD TYPE; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARAGINE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GINSENOSIDES; ION CHANNEL GATING; LEUCINE; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; XENOPUS LAEVIS;

EID: 67650744877     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.1224     Document Type: Article

References (26)

1. Hille B., "Ion Channels of Excitable Membranes," Sinauer Associates, Inc., Sunderland, MA, 2001.
2. Miller R. J., Trends Neurosci., 24, 445-449 (2001).
3. Kraus R. L., Hering S., Grabner M., Ostler D., Striessinig J., J. Biol. Chem., 273, 27206-27212 (1998).
4. Hering S., Trends Pharmacol. Sci., 23, 509-513 (2002).
5. Sokolov S., Timin E., Hering S., Circ. Res., 89, 700-708 (2001).
6. He M., J. Biol. Chem., 272, 2629-2633 (1997).
7. Yamaguchi S., Zhorov B. S., Yoshioka K., Nagao T., Ichijo H., Adachi- Akahane S., Mol. Pharmacol., 64, 235-248 (2003).
8. Nah S. Y., Korean J. Ginseng Sci., 21, 1-12 (1997).
9. Nah S. Y., Kim D. H., Rhim H., CNS Drug Rev., 13, 381-404 (2007).
10. Nah S. Y., McCleskey E. W., J. Ethnopharmacol., 42, 45-51 (1994).
11. Nah S. Y., Park H. J., McCleskey E. W., Proc. Natl. Acad. Sci. U.S.A., 92, 8739-8743 (1995).
12. Choi S., Jung S. Y., Kim C. H., Kim H. S., Rhim H., J. Ethnopharmacol., 74, 75-81 (2001).
13. Rhim H., Kim H., Lee D. Y., Oh T. H., Nah S. Y., Eur. J. Pharmacol., 436, 151-158 (2002).
14. Lee Jun-H., Jeong S. M., Kim J. H., Lee B. H., Yoon I. S., Lee Joon- H., Choi S. H., Lee S. M., Park Y. S., Lee Jung-H., Kim S. S., Kim H. C., Lee B. Y., Nah S. Y., Mol. Cells, 21, 52-62 (2006).
15. Jeong S. M., Lee Jun-H., Kim J. H., Lee B. H., Yoon I. S., Lee Joon- H., Kim D. H., Rhim H., Kim Y., Nah S. Y., Mol. Cells, 18, 383-389 (2004).
16. Triggle D. J., Biochem. Pharmacol., 74, 1-9 (2007).
17. Peterson B. Z., Johnson B. D., Hockerman G. H., Acheson M., Scheuer T., Catterall W. A., J. Biol. Chem., 272, 18752-18758 (1997).
18. Lee J. H., Lee B. H., Choi S. H., Yoon I. S., Shin T. J., Pyo M. K., Lee S. M., Kim H. C., Nah S. Y., Brain Res., 1203, 61-67 (2008).
19. Calin-Jageman I., Lee A., J. Neurochem., 105, 573-583 (2008).
20. McDonald T., Pelzer D., Trautwein W., J. Physiol., 414, 569-586 (1989).
21. Sokolov S., Weiss R. G., Kurka B., Gapp F., Hering S., J. Physiol., 519, 315-1222 (1999).
22. Lee J. H., Lee B. H., Choi S. H., Yoon I. S., Pyo M. K., Shin T. J., Choi W. S., Lim Y., Rhim H., Won K. H., Lim Y. W., Choe H., Kim D. H., Kim Y. I., Nah S. Y., Mol. Pharmacol., 73, 619-626 (2008).
23. Lee B. H., Lee Jun-H., Yoon I. S., Lee Joon-H., Choi S. H., Shin T. J., Pyo M. K., Choi W. S., Lee S. M., Lim Y., Rhim H., Nah S. Y., Biol. Pharm. Bull., 30, 1721-1726 (2007).
24. Gillis C. N., Biochem. Pharmacol., 54, 1-8 (1997).
25. Gao B. Y., Li X. J., Liu L., Zhang B. H., Yao Xue Xue Bao., 27, 641-644 (1992).
26. Yang Y., He K., Wu T., Li Q., Zhang J. S., Fu Z. G., Shi Yan Sheng Wu Xue Bao., 32, 349-352 (1999).