Factor-induced reprogramming and zinc finger nuclease-aided gene targeting cause different genome instability in β-thalassemia induced pluripotent stem cells (iPSCs)

Journal of Biological Chemistry

Volumn 290, Issue 19, 2015, Pages 12079-12089

  Ma, Ning ^a   Shan, Yongli ^a   Liao, Baojian ^a   Kong, Guanyi ^b   Wang, Cheng ^b   Huang, Ke ^a   Zhang, Hui ^a   Cai, Xiujuan ^a   Chen, Shubin ^a   Pei, Duanqing ^a   Chen, Nansheng ^c   Pan, Guangjin ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b Wuhan Frasergen Bioinformatics Company Limited   (China)

^c SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; DRUG THERAPY; GENETIC ENGINEERING; MOBILE SECURITY; NUCLEOTIDES; STEM CELLS; VIRUSES; ZINC;

CLINICAL APPLICATION; COMPARATIVE GENOMIC HYBRIDIZATIONS; COPY NUMBER VARIATIONS; DRUG RESISTANCE GENES; GENOME INSTABILITY; INDUCED PLURIPOTENT STEM CELLS; SINGLE NUCLEOTIDES; ZINC FINGER NUCLEASE;

GENES;

CRE RECOMBINASE; HEMOGLOBIN BETA CHAIN; ZINC FINGER NUCLEASE; ENDONUCLEASE; RIBONUCLEASE; ZINC FINGER PROTEIN;

ALLELE; AMNION CELL; ARTICLE; BETA THALASSEMIA; CELL DIFFERENTIATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; EMBRYO; EXOME; FETUS; GENE; GENE DELETION; GENE INSERTION; GENE SEQUENCE; GENE TARGETING; GENETIC VARIABILITY; GENOMIC INSTABILITY; HBB GENE; HOMOZYGOTE; HUMAN; HUMAN CELL; INDEL MUTATION; INTRON; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; POINT MUTATION; PRIORITY JOURNAL; RNA EDITING; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC CELL; TARGETED GENE REPAIR; ANIMAL; CHROMOSOME; CYTOLOGY; DNA MICROARRAY; ERYTHROBLAST; GENETICS; METABOLISM; MOUSE; MUTATION; ULTRASTRUCTURE;

ALLELES; ANIMALS; BETA-GLOBINS; BETA-THALASSEMIA; CELL DIFFERENTIATION; CELLULAR REPROGRAMMING; CHROMOSOMES; COMPARATIVE GENOMIC HYBRIDIZATION; DNA COPY NUMBER VARIATIONS; ENDONUCLEASES; ENDORIBONUCLEASES; ERYTHROBLASTS; EXOME; GENE DELETION; GENE TARGETING; GENETIC VARIATION; GENOMIC INSTABILITY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ZINC FINGERS;

EID: 84929190623     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.624999     Document Type: Article

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