Melanoma differentiation associated gene-7/interleukin-24 induces caspase-3 denitrosylation to facilitate the activation of cancer cell apoptosis

Journal of Interferon and Cytokine Research

Volumn 35, Issue 3, 2015, Pages 157-167

  Tian, Hui ^a   Zhang, De Fang ^a   Zhang, Bao Fu ^a   Li, Hui Zhong ^a   Zhang, Qing ^a   Li, Lian Tao ^a   Pei, Dong Sheng ^a   Zheng, Jun Nian ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; CASPASE 3; FAS ANTIGEN; INTERLEUKIN 24; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITROPRUSSIDE SODIUM; SMALL INTERFERING RNA; THIOREDOXIN REDUCTASE 2; INTERLEUKIN DERIVATIVE; INTERLEUKIN-24; TXNRD2 PROTEIN, HUMAN;

ADENOVIRIDAE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOMA CELL; CHEMICAL MODIFICATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DENITROSYLATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; ANTIBODY SPECIFICITY; GENE TRANSFER; GENETICS; HELA CELL LINE; METABOLISM; MOLECULAR CLONING; TRANSGENE;

ADENOVIRIDAE;

ADENOVIRIDAE; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CLONING, MOLECULAR; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; INTERLEUKINS; ORGAN SPECIFICITY; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; THIOREDOXIN REDUCTASE 2; TRANSGENES;

EID: 84929174195     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2014.0061     Document Type: Article

References (26)

1. Ashkenazi A, Dixit VM. 1998. Death receptors: signaling and modulation. Science 281(5381):1305-1308.
2. Benhar M, Forrester MT, Hess DT, Stamler JS. 2008. Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. Science 320(5879):1050-1054.
3. Benhar M, Forrester MT, Stamler JS. 2009. Protein deni-trosylation: enzymatic mechanisms and cellular functions. Nat Rev Mol Cell Biol 10(10):721-732.
4. Boatright KM, Salvesen GS. 2003. Caspase activation. Bio-chem Soc Symp (70):233-242.
5. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. 1999. Role of poly(ADP-ribose) poly-merase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 274(33):22932-22940.
6. Chada S, Sutton RB, Ekmekcioglu S, Ellerhorst J, Mumm JB, Leitner WW, Yang HY, Sahin AA, Hunt KK, Fuson KL, Poindexter N, Roth JA, Ramesh R, Grimm EA, Mhashilkar AM. 2004. MDA-7/IL-24 is a unique cytokine-tumor suppressor in the IL-10 family. Int Immunopharmacol 4(5): 649-667.
7. Ellerhorst JA, Prieto VG, Ekmekcioglu S, Broemeling L, Yekell S, Chada S, Grimm EA. 2002. Loss of MDA-7 expression with progression of melanoma. J Clin Oncol 20(4):1069-1074.
8. Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P. 2003. mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. Cancer Biol Ther 2(4 Suppl 1):S23-37.
9. Gopalan B, Litvak A, Sharma S, Mhashilkar AM, Chada S, Ramesh R. 2005. Activation of the Fas-FasL signaling pathway by MDA-7/IL-24 kills human ovarian cancer cells. Cancer Res 65(8):3017-3024.
10. Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ. 2004. Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. EMBO J 23(10):2134-2145.
11. Hitoshi Y, Lorens J, Kitada SI, Fisher J, LaBarge M, Ring HZ, Francke U, Reed JC, Kinoshita S, Nolan GP. 1998. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity 8(4):461-471.
12. Jacobson MD, Weil M, Raff MC. 1997. Programmed cell death in animal development. Cell 88(3):347-354.
13. Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. 1995. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11(12):2477-2486.
14. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME. 1995. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14(22):5579-5588.
15. Lebedeva IV, Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Gupta P, Nemunaitis J, Cunningham C, Yacoub A, Dent P, Fisher PB. 2005. mda-7/IL-24: exploiting cancer's Achilles' heel. Mol Ther 11(1):4-18.
16. Madireddi MT, Su ZZ, Young CS, Goldstein NI, Fisher PB. 2000. Mda-7, a novel melanoma differentiation associated gene with promise for cancer gene therapy. Adv Exp Med Biol 465:239-261.
17. Mannick JB, Hausladen A, Liu L, Hess DT, Zeng M, Miao QX, Kane LS, Gow AJ, Stamler JS. 1999. Fas-induced caspase denitrosylation. Science 284(5414):651-654.
18. McGinnis KM, Gnegy ME, Park YH, Mukerjee N, Wang KK. 1999. Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem Biophys Res Commun 263(1): 94-99.
19. Mhashilkar AM, Schrock RD, Hindi M, Liao J, Sieger K, Kourouma F, Zou-Yang XH, Onishi E, Takh O, Vedvick TS, Fanger G, Stewart L, Watson GJ, Snary D, Fisher PB, Saeki T, Roth JA, Ramesh R, Chada S. 2001. Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy. Mol Med 7(4):271-282.
20. Rossig L, Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Mulsch A, Dimmeler S. 1999. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem 274(11):6823-6826.
21. Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G, Vandenabeele P. 2004. Toxic proteins released from mitochondria in cell death. Oncogene 23(16):2861-2874.
22. Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Lebedeva IV, Dent P, Pestka S, Fisher PB. 2003. MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev 14(1):35-51.
23. Thompson CB. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267(5203):1456-1462.
24. Whitaker EL, Filippov VA, Duerksen-Hughes PJ. 2012. Inter-leukin 24: mechanisms and therapeutic potential of an anticancer gene. Cytokine Growth Factor Rev 23(6):323-331.
25. Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL. 2006. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A 103(48):18314-18319.
26. Zhang X, Kang X, Shi L, Li J, Xu W, Qian H, Wu M, Yin Z. 2008. mda-7/IL-24 induces apoptosis in human HepG2 hep-atoma cells by endoplasmic reticulum stress. Oncol Rep 20(2):437-442.