Modeling, molecular dynamics, and docking assessment of transcription factor rho: A potential drug target in brucella melitensis 16M

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 1897-1912

  Pradeepkiran, Jangampalli Adi ^a   Kumar, Konidala Kranthi ^a   Kumar, Yellapu Nanda ^b   Bhaskar, Matcha ^a  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b VECTOR CONTROL RESEARCH CENTRE   (India)

Author keywords

ADMET analysis; Brucellosis; Rho proteins; SMD simulations; Therapeutics; Transcription inhibitors

Indexed keywords

PROTEIN INHIBITOR; TRANSCRIPTION TERMINATION FACTOR RHO; UNCLASSIFIED DRUG; ZINC 2493454; ZINC 72319544; ANTIINFECTIVE AGENT; RHO FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRUCELLA MELITENSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ESCHERICHIA COLI; HYDROGEN BOND; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DATABASE; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; TRANSCRIPTION TERMINATION;

ANTI-BACTERIAL AGENTS; BRUCELLA MELITENSIS; DRUG DISCOVERY; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; RHO FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION TERMINATION, GENETIC;

EID: 84929166650     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S77020     Document Type: Article

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