-
1
-
-
79955399340
-
Definition and classification of cancer cachexia: An international consensus
-
Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12(5):489-95
-
(2011)
Lancet Oncol
, vol.12
, Issue.5
, pp. 489-495
-
-
Fearon, K.1
Strasser, F.2
Anker, S.D.3
-
2
-
-
46249115321
-
Cachexia worsens prognosis in patients with resectable pancreatic cancer
-
Bachmann J, Heiligensetzer M, Krakowski-Roosen H, et al. Cachexia worsens prognosis in patients with resectable pancreatic cancer. J Gastrointest Surg 2008;12(7):1193-201
-
(2008)
J Gastrointest Surg
, vol.12
, Issue.7
, pp. 1193-1201
-
-
Bachmann, J.1
Heiligensetzer, M.2
Krakowski-Roosen, H.3
-
3
-
-
78650411136
-
Cachexia as a major underestimated and unmet medical need: Facts and numbers
-
von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachexia Sarcopenia Muscle 2010;1(1):1-5
-
(2010)
J Cachexia Sarcopenia Muscle
, vol.1
, Issue.1
, pp. 1-5
-
-
Von Haehling, S.1
Anker, S.D.2
-
5
-
-
79951882924
-
Cancer cachexia: Traditional therapies and novel molecular mechanism-based approaches to treatment
-
Kumar NB, Kazi A, Smith T, et al. Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment. Curr Treat Options Oncol 2010;11(3-4):107-17
-
(2010)
Curr Treat Options Oncol
, vol.11
, Issue.3-4
, pp. 107-117
-
-
Kumar, N.B.1
Kazi, A.2
Smith, T.3
-
6
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355(24):2542-50
-
(2006)
N Engl J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
7
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26(21):3543-51
-
(2008)
J Clin Oncol
, vol.26
, Issue.21
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
-
8
-
-
77950507423
-
Body composition in patients with non-small cell lung cancer: A contemporary view of cancer cachexia with the use of computed tomography image analysis
-
Baracos VE, Reiman T, Mourtzakis M, et al. Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis. Am J Clin Nutr 2010;91(4):1133S-7S
-
(2010)
Am J Clin Nutr
, vol.91
, Issue.4
, pp. 1133S-7S
-
-
Baracos, V.E.1
Reiman, T.2
Mourtzakis, M.3
-
9
-
-
84876581806
-
Cancer cachexia in the age of obesity: Skeletal muscle depletion is a powerful prognostic factor, independent of body mass index
-
Martin L, Birdsell L, Macdonald N, et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 2013;31(12):1539-47
-
(2013)
J Clin Oncol
, vol.31
, Issue.12
, pp. 1539-1547
-
-
Martin, L.1
Birdsell, L.2
Macdonald, N.3
-
10
-
-
84879630960
-
Diaphragm and ventilatory dysfunction during cancer cachexia
-
Roberts BM, Ahn B, Smuder AJ, et al. Diaphragm and ventilatory dysfunction during cancer cachexia. FASEB J 2013;27(7):2600-10
-
(2013)
FASEB J
, vol.27
, Issue.7
, pp. 2600-2610
-
-
Roberts, B.M.1
Ahn, B.2
Smuder, A.J.3
-
11
-
-
84948150423
-
Cachexia: Clinical features when inflammation drives malnutrition
-
Laviano A, Koverech A, Mari A. Cachexia: clinical features when inflammation drives malnutrition. Proc Nutr Soc 2015;1-7
-
(2015)
Proc Nutr Soc
, pp. 1-7
-
-
Laviano, A.1
Koverech, A.2
Mari, A.3
-
12
-
-
84870894707
-
The potential of ghrelin in the treatment of cancer cachexia
-
Argiles JM, Stemmler B. The potential of ghrelin in the treatment of cancer cachexia. Expert Opin Biol Ther 2013;13(1):67-76
-
(2013)
Expert Opin Biol Ther
, vol.13
, Issue.1
, pp. 67-76
-
-
Argiles, J.M.1
Stemmler, B.2
-
15
-
-
84873406669
-
Understanding the mechanisms and treatment options in cancer cachexia
-
Fearon K, Arends J, Baracos V. Understanding the mechanisms and treatment options in cancer cachexia. Nature reviews Clinical oncology 2013;10(2):90-9
-
(2013)
Nature Reviews Clinical Oncology
, vol.10
, Issue.2
, pp. 90-99
-
-
Fearon, K.1
Arends, J.2
Baracos, V.3
-
16
-
-
0032907404
-
Artificial nutrition in cancer patients: Which route, what composition?
-
Bozzetti F, Gavazzi C, Mariani L, Crippa F. Artificial nutrition in cancer patients: which route, what composition? World J Surg 1999;23(6):577-83
-
(1999)
World J Surg
, vol.23
, Issue.6
, pp. 577-583
-
-
Bozzetti, F.1
Gavazzi, C.2
Mariani, L.3
Crippa, F.4
-
17
-
-
0027366422
-
Effect of dietary counseling on food intake, body weight, response rate, survival, and quality of life in cancer patients undergoing chemotherapy: A prospective, randomized study
-
Ovesen L, Allingstrup L, Hannibal J, et al. Effect of dietary counseling on food intake, body weight, response rate, survival, and quality of life in cancer patients undergoing chemotherapy: a prospective, randomized study. J Clin Oncol 1993;11(10):2043-9
-
(1993)
J Clin Oncol
, vol.11
, Issue.10
, pp. 2043-2049
-
-
Ovesen, L.1
Allingstrup, L.2
Hannibal, J.3
-
18
-
-
34249029380
-
Insulin treatment in cancer cachexia: Effects on survival, metabolism, and physical functioning
-
Lundholm K, Korner U, Gunnebo L, et al. Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning. Clin Cancer Res 2007;13(9):2699-706
-
(2007)
Clin Cancer Res
, vol.13
, Issue.9
, pp. 2699-2706
-
-
Lundholm, K.1
Korner, U.2
Gunnebo, L.3
-
19
-
-
84876070234
-
Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: A doubleblind placebo-controlled trial
-
Del Fabbro E, Dev R, Hui D, et al. Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a doubleblind placebo-controlled trial. J Clin Oncol 2013;31(10):1271-6
-
(2013)
J Clin Oncol
, vol.31
, Issue.10
, pp. 1271-1276
-
-
Del Fabbro, E.1
Dev, R.2
Hui, D.3
-
20
-
-
80755153256
-
Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia
-
Murphy RA, Yeung E, Mazurak VC, Mourtzakis M. Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia. Br J Cancer 2011;105(10):1469-73
-
(2011)
Br J Cancer
, vol.105
, Issue.10
, pp. 1469-1473
-
-
Murphy, R.A.1
Yeung, E.2
Mazurak, V.C.3
Mourtzakis, M.4
-
21
-
-
84879484482
-
Experiences with dronabinol (delta-tetrahydrocannabinol) in oncological patients with anorexiacachexia syndrome. Illustration of clinical problems and therapy based on 2 case reports
-
Gorter RW. [Experiences with dronabinol (delta-tetrahydrocannabinol) in oncological patients with anorexiacachexia syndrome. Illustration of clinical problems and therapy based on 2 case reports]. Schmerz 2004;18(Suppl 2):S31-3
-
(2004)
Schmerz
, vol.18
, pp. S31-S33
-
-
Gorter, R.W.1
-
22
-
-
78650641328
-
Treatment of cachexia in oncology
-
Tazi E, Errihani H. Treatment of cachexia in oncology. Indian J Palliat Care 2010;16(3):129-37
-
(2010)
Indian J Palliat Care
, vol.16
, Issue.3
, pp. 129-137
-
-
Tazi, E.1
Errihani, H.2
-
23
-
-
84866265952
-
The role of thalidomide and placebo for the treatment of cancerrelated anorexia-cachexia symptoms: Results of a double-blind placebocontrolled randomized study
-
Yennurajalingam S, Willey JS, Palmer JL, et al. The role of thalidomide and placebo for the treatment of cancerrelated anorexia-cachexia symptoms: results of a double-blind placebocontrolled randomized study. J Palliat Med 2012;15(10):1059-64
-
(2012)
J Palliat Med
, vol.15
, Issue.10
, pp. 1059-1064
-
-
Yennurajalingam, S.1
Willey, J.S.2
Palmer, J.L.3
-
24
-
-
84875804562
-
Effects of enobosarm on muscle wasting and physical function in patients with cancer: A double-blind, randomised controlled phase 2 trial
-
Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45
-
(2013)
Lancet Oncol
, vol.14
, Issue.4
, pp. 335-345
-
-
Dobs, A.S.1
Boccia, R.V.2
Croot, C.C.3
-
25
-
-
84896723718
-
Results from two Phase 3 randomized trials of enobosarm, selective androgen receptor modulator (SARM), for the prevention and treatment of muscle wasting in NSCLC
-
Crawford J, Dalton JT, Hancock ML. Results from two Phase 3 randomized trials of enobosarm, selective androgen receptor modulator (SARM), for the prevention and treatment of muscle wasting in NSCLC. Eur J Cancer 2013;49(Suppl 2):LBA21
-
(2013)
Eur J Cancer
, vol.49
, pp. LBA21
-
-
Crawford, J.1
Dalton, J.T.2
Hancock, M.L.3
-
26
-
-
0033540056
-
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
-
Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402(6762):656-60
-
(1999)
Nature
, vol.402
, Issue.6762
, pp. 656-660
-
-
Kojima, M.1
Hosoda, H.2
Date, Y.3
-
27
-
-
2942530618
-
Ghrelin-A hormone with multiple functions
-
Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin-a hormone with multiple functions. Front Neuroendocrinol 2004;25(1):27-68
-
(2004)
Front Neuroendocrinol
, vol.25
, Issue.1
, pp. 27-68
-
-
Korbonits, M.1
Goldstone, A.P.2
Gueorguiev, M.3
Grossman, A.B.4
-
28
-
-
15544385058
-
Ghrelin: Structure and function
-
Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005;85(2):495-522
-
(2005)
Physiol Rev
, vol.85
, Issue.2
, pp. 495-522
-
-
Kojima, M.1
Kangawa, K.2
-
29
-
-
2942528459
-
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
-
van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004;25(3):426-57
-
(2004)
Endocr Rev
, vol.25
, Issue.3
, pp. 426-457
-
-
Van Der Lely, A.J.1
Tschop, M.2
Heiman, M.L.3
Ghigo, E.4
-
30
-
-
0040184557
-
Ghrelin strongly stimulates growth hormone release in humans
-
Takaya K, Ariyasu H, Kanamoto N, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85(12):4908-11
-
(2000)
J Clin Endocrinol Metab
, vol.85
, Issue.12
, pp. 4908-4911
-
-
Takaya, K.1
Ariyasu, H.2
Kanamoto, N.3
-
31
-
-
49349099488
-
Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine
-
Jerlhag E. Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 2008;13(3-4):358-63
-
(2008)
Addict Biol
, vol.13
, Issue.3-4
, pp. 358-363
-
-
Jerlhag, E.1
-
32
-
-
0037456519
-
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
-
Cowley MA, Smith RG, Diano S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003;37(4):649-61
-
(2003)
Neuron
, vol.37
, Issue.4
, pp. 649-661
-
-
Cowley, M.A.1
Smith, R.G.2
Diano, S.3
-
33
-
-
74749097279
-
Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats
-
Mano-Otagiri A, Iwasaki-Sekino A, Nemoto T, et al. Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. Regul Pept 2010;160(1-3):81-90
-
(2010)
Regul Pept
, vol.160
, Issue.1-3
, pp. 81-90
-
-
Mano-Otagiri, A.1
Iwasaki-Sekino, A.2
Nemoto, T.3
-
34
-
-
84883197539
-
Inhibition of Cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice
-
Garcia JM, Scherer T, Chen JA, et al. Inhibition of Cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice. Endocrinology 2013;154(9):3118-29
-
(2013)
Endocrinology
, vol.154
, Issue.9
, pp. 3118-3129
-
-
Garcia, J.M.1
Scherer, T.2
Chen, J.A.3
-
35
-
-
84922095761
-
Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients
-
Beck DE, Sweeney WB, McCarter MD, et al. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis 2014;29(12):1527-34
-
(2014)
Int J Colorectal Dis
, vol.29
, Issue.12
, pp. 1527-1534
-
-
Beck, D.E.1
Sweeney, W.B.2
McCarter, M.D.3
-
36
-
-
84904250550
-
Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131
-
Van der Ploeg L, Laken H, Sharma S, et al. Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131. Life Sci 2014;109(1):20-9
-
(2014)
Life Sci
, vol.109
, Issue.1
, pp. 20-29
-
-
Van Der Ploeg, L.1
Laken, H.2
Sharma, S.3
-
38
-
-
3242749843
-
Ghrelin inhibits leptin-and activationinduced proinflammatory cytokine expression by human monocytes and T cells
-
Dixit VD, Schaffer EM, Pyle RS, et al. Ghrelin inhibits leptin-and activationinduced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004;114(1):57-66
-
(2004)
J Clin Invest
, vol.114
, Issue.1
, pp. 57-66
-
-
Dixit, V.D.1
Schaffer, E.M.2
Pyle, R.S.3
-
39
-
-
84982179410
-
Ghrelin prevents tumor-and cisplatininduced muscle wasting: Characterization of multiple mechanisms involved
-
In press
-
Chen J, Splenser A, Guillory B, et al. Ghrelin prevents tumor-and cisplatininduced muscle wasting: characterization of multiple mechanisms involved. J Cachexia Sacropenia Muscle 2015; In press
-
(2015)
J Cachexia Sacropenia Muscle
-
-
Chen, J.1
Splenser, A.2
Guillory, B.3
-
40
-
-
2442419837
-
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells
-
Li WG, Gavrila D, Liu X, et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 2004;109(18):2221-6
-
(2004)
Circulation
, vol.109
, Issue.18
, pp. 2221-2226
-
-
Li, W.G.1
Gavrila, D.2
Liu, X.3
-
41
-
-
9844226786
-
Oral administration of growth hormone (GH) releasing peptidemimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults
-
Chapman IM, Pescovitz OH, Murphy G, et al. Oral administration of growth hormone (GH) releasing peptidemimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults. J Clin Endocrinol Metab 1997;82(10):3455-63
-
(1997)
J Clin Endocrinol Metab
, vol.82
, Issue.10
, pp. 3455-3463
-
-
Chapman, I.M.1
Pescovitz, O.H.2
Murphy, G.3
-
42
-
-
0030762351
-
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
-
Guan XM, Yu H, Palyha OC, et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997;48(1):23-9
-
(1997)
Brain Res Mol Brain Res
, vol.48
, Issue.1
, pp. 23-29
-
-
Guan, X.M.1
Yu, H.2
Palyha, O.C.3
-
43
-
-
29044434688
-
Expression of ghrelin receptor mRNA in the rat and the mouse brain
-
Zigman JM, Jones JE, Lee CE, et al. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 2006;494(3):528-48
-
(2006)
J Comp Neurol
, vol.494
, Issue.3
, pp. 528-548
-
-
Zigman, J.M.1
Jones, J.E.2
Lee, C.E.3
-
44
-
-
11144310116
-
Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus
-
Mondal MS, Date Y, Yamaguchi H, et al. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept 2005;126(1-2):55-9
-
(2005)
Regul Pept
, vol.126
, Issue.1-2
, pp. 55-59
-
-
Mondal, M.S.1
Date, Y.2
Yamaguchi, H.3
-
45
-
-
0032744366
-
Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
-
Willesen MG, Kristensen P, Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 1999;70(5):306-16
-
(1999)
Neuroendocrinology
, vol.70
, Issue.5
, pp. 306-316
-
-
Willesen, M.G.1
Kristensen, P.2
Romer, J.3
-
46
-
-
84908510168
-
Ghrelin signalling in beta-cells regulates insulin secretion and blood glucose
-
Yada T, Damdindorj B, Rita RS, et al. Ghrelin signalling in beta-cells regulates insulin secretion and blood glucose. Diabetes obesity Metabol 2014;16(Suppl 1):111-17
-
(2014)
Diabetes Obesity Metabol
, vol.16
, pp. 111-117
-
-
Yada, T.1
Damdindorj, B.2
Rita, R.S.3
-
47
-
-
3042735648
-
The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
-
Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002;87(6):2988
-
(2002)
J Clin Endocrinol Metab
, vol.87
, Issue.6
, pp. 2988
-
-
Gnanapavan, S.1
Kola, B.2
Bustin, S.A.3
-
48
-
-
38549133092
-
Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
-
Sun Y, Butte NF, Garcia JM, Smith RG. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 2008;149(2):843-50
-
(2008)
Endocrinology
, vol.149
, Issue.2
, pp. 843-850
-
-
Sun, Y.1
Butte, N.F.2
Garcia, J.M.3
Smith, R.G.4
-
49
-
-
84910027414
-
Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes
-
Kitahara A, Takahashi K, Moriya R, et al. Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes. J Cell Physiol 2015;230(1):199-209
-
(2015)
J Cell Physiol
, vol.230
, Issue.1
, pp. 199-209
-
-
Kitahara, A.1
Takahashi, K.2
Moriya, R.3
-
50
-
-
84873367527
-
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice
-
Porporato PE, Filigheddu N, Reano S, et al. Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice. J Clin Invest 2013;123(2):611-22
-
(2013)
J Clin Invest
, vol.123
, Issue.2
, pp. 611-622
-
-
Porporato, P.E.1
Filigheddu, N.2
Reano, S.3
-
51
-
-
2942670638
-
Ghrelin increases energy intake in cancer patients with impaired appetite: Acute, randomized, placebo-controlled trial
-
Neary NM, Small CJ, Wren AM, et al. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 2004;89(6):2832-6
-
(2004)
J Clin Endocrinol Metab
, vol.89
, Issue.6
, pp. 2832-2836
-
-
Neary, N.M.1
Small, C.J.2
Wren, A.M.3
-
52
-
-
38549158121
-
Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: A randomised, placebocontrolled, double-blind, doublecrossover study
-
Strasser F, Lutz TA, Maeder MT, et al. Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebocontrolled, double-blind, doublecrossover study. Br J Cancer 2008;98(2):300-8
-
(2008)
Br J Cancer
, vol.98
, Issue.2
, pp. 300-308
-
-
Strasser, F.1
Lutz, T.A.2
Maeder, M.T.3
-
53
-
-
84865621644
-
Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: A prospective, randomized, placebo-controlled phase 2 study
-
Hiura Y, Takiguchi S, Yamamoto K, et al. Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study. Cancer 2012;118(19):4785-94
-
(2012)
Cancer
, vol.118
, Issue.19
, pp. 4785-4794
-
-
Hiura, Y.1
Takiguchi, S.2
Yamamoto, K.3
-
54
-
-
77951000967
-
Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients: A randomized doubleblind study
-
Lundholm K, Gunnebo L, Korner U, et al. Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients: a randomized doubleblind study. Cancer 2010;116(8):2044-52
-
(2010)
Cancer
, vol.116
, Issue.8
, pp. 2044-2052
-
-
Lundholm, K.1
Gunnebo, L.2
Korner, U.3
-
55
-
-
35549012275
-
Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: Results of a phase I, randomized, placebocontrolled, multiple-dose study in healthy volunteers
-
Garcia JM, Polvino WJ. Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebocontrolled, multiple-dose study in healthy volunteers. Oncologist 2007;12(5):594-600
-
(2007)
Oncologist
, vol.12
, Issue.5
, pp. 594-600
-
-
Garcia, J.M.1
Polvino, W.J.2
-
56
-
-
10844221772
-
Growth hormone releasing hormone plasmid supplementation, a potential treatment for cancer cachexia, does not increase tumor growth in nude mice
-
Khan AS, Smith LC, Anscombe IW, et al. Growth hormone releasing hormone plasmid supplementation, a potential treatment for cancer cachexia, does not increase tumor growth in nude mice. Cancer Gene Ther 2005;12(1):54-60
-
(2005)
Cancer Gene Ther
, vol.12
, Issue.1
, pp. 54-60
-
-
Khan, A.S.1
Smith, L.C.2
Anscombe, I.W.3
-
57
-
-
84863140668
-
Pathophysiological role of hormones and cytokines in cancer cachexia
-
Kim HJ, Kim HJ, Yun J, et al. Pathophysiological role of hormones and cytokines in cancer cachexia. J Korean Med Sci 2012;27(2):128-34
-
(2012)
J Korean Med Sci
, vol.27
, Issue.2
, pp. 128-134
-
-
Kim, H.J.1
Kim, H.J.2
Yun, J.3
-
58
-
-
84951557346
-
Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: Preclinical profile
-
Pietra C, Takeda Y, Tazawa-Ogata N, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile. J Cachexia Sarcopenia Muscle 2014;5(4):329-37
-
(2014)
J Cachexia Sarcopenia Muscle
, vol.5
, Issue.4
, pp. 329-337
-
-
Pietra, C.1
Takeda, Y.2
Tazawa-Ogata, N.3
-
59
-
-
84924989934
-
An open-label clinical trial of the effects of age and gender on the pharmacodynamics, pharmacokinetics and safety of the ghrelin receptor agonist anamorelin
-
Leese PT, Trang JM, Blum RA, Groot E. An open-label clinical trial of the effects of age and gender on the pharmacodynamics, pharmacokinetics and safety of the ghrelin receptor agonist anamorelin. Clin Pharm Drug Dev 2015;4(2):112-20
-
(2015)
Clin Pharm Drug Dev
, vol.4
, Issue.2
, pp. 112-120
-
-
Leese, P.T.1
Trang, J.M.2
Blum, R.A.3
Groot, E.4
-
60
-
-
35548969512
-
Biologic activity of RC-1291, a novel oral ghrelin mimetic for cancer anorexia/cachexia: Results from a phase i randomized, double-blind, placebo-controlled trial in healthy volunteer
-
Kumor K, Polvino W. Biologic activity of RC-1291, a novel oral ghrelin mimetic for cancer anorexia/cachexia: results from a phase I randomized, double-blind, placebo-controlled trial in healthy volunteer. Supportive care cancer 2006;14:583-687
-
(2006)
Supportive Care Cancer
, vol.14
, pp. 583-687
-
-
Kumor, K.1
Polvino, W.2
-
61
-
-
67349182900
-
Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers
-
Garcia JM, Polvino WJ. Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers. Growth Horm IGF Res 2009;19(3):267-73
-
(2009)
Growth Horm IGF Res
, vol.19
, Issue.3
, pp. 267-273
-
-
Garcia, J.M.1
Polvino, W.J.2
-
62
-
-
84874083358
-
Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: A multicenter, randomized, double-blind, crossover, pilot study
-
Garcia JM, Friend J, Allen S. Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study. Support Care Cancer 2013;21(1):129-37
-
(2013)
Support Care Cancer
, vol.21
, Issue.1
, pp. 129-137
-
-
Garcia, J.M.1
Friend, J.2
Allen, S.3
-
63
-
-
84926127858
-
Anamorelin for patients with cancer cachexia: An integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials
-
Garcia JM, Boccia RV, Graham CD, et al. Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. Lancet Oncol 2015;16(1):108-16
-
(2015)
Lancet Oncol
, vol.16
, Issue.1
, pp. 108-116
-
-
Garcia, J.M.1
Boccia, R.V.2
Graham, C.D.3
-
64
-
-
84927583660
-
Anamorelin for patients with cancer cachexia: An integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials
-
Garcia JM, Boccia RV, Graham CD, et al. Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. Lancet Oncol 2014;15
-
(2014)
Lancet Oncol
, vol.15
-
-
Garcia, J.M.1
Boccia, R.V.2
Graham, C.D.3
-
65
-
-
84929220370
-
-
European Cancer Congress Amsterdam, The Netherlands 1308 [Last accessed on 14 November 2013]
-
Temel J, Bondarde S, Jain M, et al. Efficacy and safety of anamorelin HCl in NSCLC patients: results from a randomized, double-blind, placebocontrolled, multicenter Phase II study. European Cancer Congress Amsterdam, The Netherlands 1308, 2013. Available from: wwwpostersubmissioncom/ board/ [Last accessed on 14 November 2013]
-
(2013)
Efficacy and Safety of Anamorelin HCl in NSCLC Patients: Results from A Randomized, Double-blind, Placebocontrolled, Multicenter Phase II Study
-
-
Temel, J.1
Bondarde, S.2
Jain, M.3
-
66
-
-
84929220371
-
Evaluation of quality of life from a phase II study of anamorelin HCl in NSCLC patients
-
abstr 42
-
Temel JS, Bondarde SA, Jain MM, et al. Evaluation of quality of life from a phase II study of anamorelin HCl in NSCLC patients. J Clin Oncol 2013;31:Suppl 31; abstr 42
-
(2013)
J Clin Oncol
, vol.31
-
-
Temel, J.S.1
Bondarde, S.A.2
Jain, M.M.3
-
67
-
-
84929220372
-
Anamorelin for the Treatment of Cancer Anorexia-Cachexia in Advanced NSCLC Patients: Results from ROMANA 1, a Pivotal Phase 3 Study
-
abstract 5
-
Bonomi P, Temel J, Currow D, et al. Anamorelin for the Treatment of Cancer Anorexia-Cachexia in Advanced NSCLC Patients: Results From ROMANA 1, a Pivotal Phase 3 Study. Int J Radiat Oncol Biol Phys 2014;90(5S Suppl):abstract 5
-
(2014)
Int J Radiat Oncol Biol Phys
, vol.90
, Issue.5 S
-
-
Bonomi, P.1
Temel, J.2
Currow, D.3
-
68
-
-
84929220373
-
Anamorelin for the treatment of cancer anorexia-cachexia: Baseline characteristics from three phase III clinical trials (the ROMANA program)
-
abstract e20694
-
Abernethy AP, Currow D, Fearon K, et al. Anamorelin for the treatment of cancer anorexia-cachexia: Baseline characteristics from three phase III clinical trials (the ROMANA program). J Clin Oncol 2014;32(Suppl):abstract e20694
-
(2014)
J Clin Oncol
, vol.32
-
-
Abernethy, A.P.1
Currow, D.2
Fearon, K.3
-
69
-
-
84927651302
-
Anamorelin for the treatment of cancer anorexia-cachexia in NSCLC: Results from the phase 3 studies ROMANA 1 and 2
-
Temel J, Currow D, Fearon K, et al. Anamorelin for the treatment of cancer anorexia-cachexia in NSCLC: Results from the phase 3 studies ROMANA 1 and 2. Ann Oncol 2014;25(5):1-41
-
(2014)
Ann Oncol
, vol.25
, Issue.5
, pp. 1-41
-
-
Temel, J.1
Currow, D.2
Fearon, K.3
-
70
-
-
84903519847
-
Mechanisms in endocrinology: Regulation of glucose metabolism by the ghrelin system: Multiple players and multiple actions
-
Heppner KM, Tong J. Mechanisms in endocrinology: regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions. Eur J Endocrinol 2014;171(1):R21-32
-
(2014)
Eur J Endocrinol
, vol.171
, Issue.1
, pp. R21-32
-
-
Heppner, K.M.1
Tong, J.2
-
71
-
-
84881258990
-
Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model
-
Northrup R, Kuroda K, Duus EM, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer 2013;21(9):2409-15
-
(2013)
Support Care Cancer
, vol.21
, Issue.9
, pp. 2409-2415
-
-
Northrup, R.1
Kuroda, K.2
Duus, E.M.3
-
72
-
-
84879206420
-
Predicting survival in cancer patients: The role of cachexia and hormonal, nutritional and inflammatory markers
-
Utech AE, Tadros EM, Hayes TG, Garcia JM. Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers. J Cachexia Sarcopenia Muscle 2012;3(4):245-51
-
(2012)
J Cachexia Sarcopenia Muscle
, vol.3
, Issue.4
, pp. 245-251
-
-
Utech, A.E.1
Tadros, E.M.2
Hayes, T.G.3
Garcia, J.M.4
-
73
-
-
84921761442
-
Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome
-
Fujitsuka N, Uezono Y. Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome. Frontiers in pharmacology 2014;5:271
-
(2014)
Frontiers in Pharmacology
, vol.5
, pp. 271
-
-
Fujitsuka, N.1
Uezono, Y.2
|