Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia

British Journal of Cancer

Volumn 105, Issue 10, 2011, Pages 1469-1473

  Murphy, R A ^a   Yeung, E ^b   Mazurak, V C ^a   Mourtzakis, M ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

fish oil; muscle loss; n 3 fatty acids; sarcopenia

Indexed keywords

CYTOKINE; ICOSAPENTAENOIC ACID; UBIQUITIN;

APOPTOSIS; CACHEXIA; CALORIC INTAKE; CANCER CACHEXIA; CANCER CHEMOTHERAPY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; DOWN REGULATION; HUMAN; INSULIN SENSITIVITY; LEAN BODY WEIGHT; NECROSIS; NEOPLASM; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTAKE; PROTEIN SYNTHESIS; REVIEW; TREATMENT RESPONSE;

BODY COMPOSITION; CACHEXIA; CLINICAL TRIALS AS TOPIC; EICOSAPENTAENOIC ACID; HUMANS; NEOPLASMS;

EID: 80755153256     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.391     Document Type: Review

References (31)

1. Asp ML, Tian M, Wendel AA, Belury MA (2010) Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice. Int J Cancer 126: 756-763
2. Barber MD, Ross JA, Voss AC, Tisdale MJ, Fearon KC (1999) The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. Br J Cancer 81: 80-86 (Pubitemid 29415495)
3. Bougnoux P, Hajjaji N, Maheo K, Couet C, Chevalier S (2010) Fatty acids and breast cancer: sensitization to treatments and prevention of metastatic re-growth. Prog Lipid Res 49: 76-86
4. Bruera E, Strasser F, Palmer JL, Willey J, Calder K, Amyotte G, Baracos V (2003) Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. J Clin Oncol 21: 129-134
5. Dewey A, Baughan C, Dean T, Higgins B, Johnson I (2007) Eicosapentae-noic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia. Cochrane Database Syst Rev 1: CD004597
6. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, Cohen MH, Douglass Jr HO , Engstrom PF, Ezdinli EZ, Horton J, Johnson GJ, Moertel CG, Oken MM, Perlia C, Rosenbaum C, Silverstein MN, Skeel RT, Sponzo RW, Tormey DC (1980) Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 69(4): 491-497 (Pubitemid 10018703)
7. Dodesini AR, Benedini S, Terruzzi I, Sereni LP, Luzi L (2007) Protein, glucose and lipid metabolism in the cancer cachexia: a preliminary report. Acta Oncol 46: 118-120
8. Dodson S, Baracos VE, Jatoi A, Evans WJ, Cella D, Dalton JT, Steiner MS (2011) Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies. Annu Rev Med 62: 265-279
9. Evans WJ, Morley JE, Argiles J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD (2008) Cachexia: a new definition. Clin Nutr 27: 793-799
10. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, Macdonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12: 489-495
11. Fearon KC, Barber MD, Moses AG, Ahmedzai SH, Taylor GS, Tisdale MJ, Murray GD (2006) Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. J Clin Oncol 24: 3401-3407 (Pubitemid 46638896)
12. Fearon KC, Von Meyenfeldt MF, Moses AG, Van Geenen R, Roy A, Gouma DJ, Giacosa A, Van Gossum A, Bauer J, Barber MD, Aaronson NK, Voss AC, Tisdale MJ (2003) Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut 52: 1479-1486 (Pubitemid 37176729)
13. Frontera WR, Meredith CN, O0Reilly KP, Knuttgen HG, Evans WJ (1988) Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 64: 1038-1044 (Pubitemid 18088522)
14. Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F (1998) Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer 82: 395-402 (Pubitemid 28060258)
15. Jatoi A, Rowland K, Loprinzi CL, Sloan JA, Dakhil SR, MacDonald N, Gagnon B, Novotny PJ, Mailliard JA, Bushey TI, Nair S, Christensen B (2004) An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada collaborative effort. J Clin Oncol 22: 2469-2476 (Pubitemid 41115406)
16. Klastersky J, Paesmans M (2001) Response to chemotherapy, quality of life benefits and survival in advanced non-small cell lung cancer: review of literature results. Lung Cancer 34(Suppl 4): S95-S101
17. Lieffers JR, Mourtzakis M, Hall KD, McCargar LJ, Prado CM, Baracos VE (2009) A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am J Clin Nutr 89: 1173-1179
18. Magee P, Pearson S, Allen J (2008) The omega-3 fatty acid, eicosapentae-noic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation. Lipids Health Dis 7: 24
19. McNamara MJ, Alexander HR, Norton JA (1992) Cytokines and their role in the pathophysiology of cancer cachexia. JPEN J Parenter Enteral Nutr 16: 50S-55S
20. Moses AW, Slater C, Preston T, Barber MD, Fearon KC (2004) Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer 90: 996-1002 (Pubitemid 38495818)
21. Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE (2008) A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 33: 997-1006
22. Murphy RA, Mourtzakis M, Chu QSC, Baracos VE, Reiman T, Mazurak VC (2011a) Nutritional intervention with fish oil provides a benefit over standard of care on weight and skeletal muscle mass in non-small cell lung cancer patients receiving chemotherapy. Cancer 117: 1775-1782
23. Murphy RA, Mourtzakis M, Chu QSC, Baracos VE, Reiman T, Mazurak VC (2011b) Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced non-small cell lung cancer. Cancer 117: 3774-3780; doi: 10.1002/cncr.25933
24. Murphy RA, Wilke MS, Perrine M, Pawlowicz M, Mourtzakis M, Lieffers JR, Maneshgar M, Bruera E, Clandinin MT, Baracos VE, Mazurak VC (2010) Loss of adipose tissue and plasma phospholipids: relationship to survival in advanced cancer patients. Clin Nutr 29: 482-487
25. Ryan AM, Reynolds JV, Healy L, Byrne M, Moore J, Brannelly N, McHugh A, McCormack D, Flood P (2009) Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trial. Ann Surg 249: 355-363
26. Tisdale MJ (2009) Mechanisms of cancer cachexia. Physiol Rev 89: 381-410
27. van der Meij BS, Langius JA, Smit EF, Spreeuwenberg MD, von Blomberg BM, Heijboer AC, Paul MA, van Leeuwen PA (2010) Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment. J Nutr 140: 1774-1780
28. Weed HG, Ferguson ML, Gaff RL, Hustead DS, Nelson JL, Voss AC (2011) Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein-and energy-dense nutritional supplement containing eicosapentaenoic acid. Head Neck 33(7): 1027-1033
29. Wigmore SJ, Barber MD, Ross JA, Tisdale MJ, Fearon KC (2000) Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer. Nutr Cancer 36: 177-184 (Pubitemid 30437038)
30. Wigmore SJ, Fearon KC, Maingay JP, Ross JA (1997) Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. Clin Sci (Lond) 92: 215-221 (Pubitemid 27075725)
31. Xue H, Sawyer MB, Field CJ, Dieleman LA, Baracos VE (2007) Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor. Clin Cancer Res 13: 7146-7154 (Pubitemid 350276901)