Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131

Life Sciences

Volumn 109, Issue 1, 2014, Pages 20-29

  Van Der Ploeg, Lex ^a   Laken, Haley ^a   Sharma, Shubh ^a   Datta, Rakesh ^b   Halem, Heather ^b   Dong, Jesse ^b   Touvay, Caroline ^b   Teillot, Marc ^b   Noonan, Patrick ^a   Tartaglia, Lou ^c   Stoner, Liz ^a   Henderson, Bart ^a   Gottesdiener, Keith ^a   Culler, Michael ^b  

^a Rhythm Pharmaceuticals   (United States)

^b IPSEN   (France)

^c THIRD ROCK VENTURES   (United States)

Author keywords

Diabetic gastroparesis; Gastrointestinal; Ghrelin; Inflammatory bowel disease; Prokinetic

Indexed keywords

GHRELIN RECEPTOR; GLUCOSE; INTESTINE CONTRACTION STIMULATING AGENT; PROKINETIC AGENT; RM 131; TZP 102; ULIMORELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL LINE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; DOG; DRUG EFFICACY; DRUG POTENCY; GASTROINTESTINAL DISEASE; HUMAN; INFLAMMATORY BOWEL DISEASE; LONG TERM CARE; MALE; MOUSE; NONHUMAN; POSTOPERATIVE ILEUS; POSTOPERATIVE PERIOD; RAT; SINGLE DRUG DOSE; STOMACH EMPTYING; STOMACH PARESIS; TISSUE INJURY;

CANIS FAMILIARIS; MUS; RATTUS; RODENTIA;

DIABETIC GASTROPARESIS; GASTROINTESTINAL; GHRELIN; INFLAMMATORY BOWEL DISEASE; PROKINETIC;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DIABETES COMPLICATIONS; DOGS; GASTRIC EMPTYING; GASTROINTESTINAL AGENTS; GASTROINTESTINAL DISEASES; GASTROINTESTINAL MOTILITY; GASTROPARESIS; GHRELIN; GROWTH HORMONE; HUMANS; ILEUS; INFLAMMATORY BOWEL DISEASES; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84904250550     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.06.003     Document Type: Article

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