Detection of new human metabolic urinary markers in chronic alcoholism and their reversal by aqueous extract of Tinospora cordifolia stem

Alcohol and Alcoholism

Volumn 50, Issue 3, 2014, Pages 271-281

  Mittal, Ashwani ^a   Dabur, Rajesh ^b,c  

^a KURUKSHETRA UNIVERSITY   (India)

^b MAHARSHI DAYANAND UNIVERSITY   (India)

^c National Research Institute of Basic Ayurvedic Sciences   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; 3,4 DIHYDROXYBUTYRIC ACID; 5 HYDROXYDOPAMINE; 5 HYDROXYINDOLE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARNITINE; CYSTATHIONINE; FATTY ACID; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GLUCURONIDE; GLYCODEOXYCHOLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HISTIDINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MELATONIN; PHENYLACETIC ACID; PICOLINIC ACID; PROLINE; PYRIMIDINE DERIVATIVE; QUINALDIC ACID; RIBOFLAVIN; SEROTONIN; TETRAHYDROBIOPTERIN; TINOSPORA CORDIFOLIA EXTRACT; TRIACYLGLYCEROL; TRYPTOPHAN; URIC ACID; GAMMA-GLUTAMYLTRANSFERASE, HUMAN; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOLISM; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD BIOCHEMISTRY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION MONITORING; LIPID METABOLISM; MALE; MEAN CORPUSCULAR VOLUME; MORNING DOSAGE; NEUROTRANSMISSION; OXIDATIVE STRESS; PLANT STEM; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RANDOMIZED CONTROLLED TRIAL; TIME OF FLIGHT MASS SPECTROMETRY; TINOSPORA CORDIFOLIA; TRIACYLGLYCEROL BLOOD LEVEL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URIC ACID BLOOD LEVEL; URINALYSIS; URINE LEVEL; BLOOD; CLINICAL TRIAL; MASS SPECTROMETRY; METABOLOMICS; PHYTOTHERAPY; TINOSPORA; TREATMENT OUTCOME; URINE;

TINOSPORA CORDIFOLIA;

ADULT; ALANINE TRANSAMINASE; ALCOHOLISM; ASPARTATE AMINOTRANSFERASES; BIOMARKERS; BLOOD GLUCOSE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ERYTHROCYTE INDICES; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; MALE; MASS SPECTROMETRY; METABOLOMICS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT STEMS; TINOSPORA; TREATMENT OUTCOME; TRIGLYCERIDES; URIC ACID;

EID: 84929154529     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agv012     Document Type: Article

References (50)

1. Antonisamy P, Dhanasekaran M, Ignacimuthu S, et al. (2014) Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats. Phytomed 21:966-9.
2. Barik J, Wonnacott S. (2009) Molecular and cellular mechanisms of action of nicotine in the CNS. Handb Exp Pharmacol 192:173-207.
3. Basuroy S, Sheth P, Mansbach CM, et al. (2005) Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine. Am J Physiol Gastrointest Liver Physiol 289: G367-75.
4. Benedetto C, Marozio L, Neri I, et al. (2000) Increased L-citrulline/L-arginine plasma ratio in severe preeclampsia. Obstet Gynecol 96:395-9.
5. Bermingham A, Price E, Marchand C, et al. (2014) A screen for the identification of inhibitors of tyrosyl-DNA phosphodiesterase 1. Planta Medica 80: PQ4.
6. Blum K, Oscar-BermanM, Badgaiyan RD, et al. (2014) Hypothesizing darkness induced alcohol intake linked to dopaminergic regulation of brain function. Psychol (Irvine) 5:282-8.
7. Bosco MC, Rapisarda A, Massazza S, et al. (2000) The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1a and-1β in macrophages. J Immunol 164:3283-91.
8. Castillo AL, Ramos JDA, De Francia JL, et al. (2014) Immunomodulatory effects of tinospora cordifolia lotion on interleukin-1, interleukin-6 and interleukin-8 levels in scabies-infected pediatric patients: a single blind, randomized trial. Intl J Pharma Sci Drug Res 6:204-10.
9. Clements K, Glautier S, Stolerman IP, et al. (1996) Classical conditioning in humans: nicotine as CS and alcohol as US. Hum Psychopharmacol 11:85-95.
10. Deas D, May MP, Randall C, et al. (2005) Naltrexone treatment of adolescent alcoholics: an open-label pilot study. J Child Adolesc Psychopharmacol 15:723-8.
11. Devaud LL, Fritschy JM, Sieghart W, et al. (1997) Bidirectional alterations of GABAA receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J Neurochem 69:126-30.
12. Erickson CK. (1996) Review of neurotransmitters and their role in alcoholism treatment. Alcohol Alcohol 31:5-11.
13. Gerlo E, Van Coster R, Lissens W, et al. (2006) Gas chromatographic-mass spectrometric analysis of N- acetylated amino acids: The first case of aminoacylase I deficiency. Anal Chimica Acta 571:191-9.
14. Gramignano G, Lusso MR, Madeddu C, et al. (2006) Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Nutrition 22:136-45.
15. Haskell WL, Camargo C Jr, Williams PT, et al. (1984) The effect of cessation and resumption of moderate alcohol intake on serum high-densitylipoprotein subfractions: a controlled study. N Engl J Med 310:805-10.
16. Heap LC, Pratt OE, Ward RJ, et al. (2002) Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers. Psychiatr Genet 12:217-24.
17. Johnson BA. (2004) Role of the serotonergic system in the neurobiology of alcoholism. CNS Drugs 18:1105-18.
18. Joshi MS, Ponthier JL, Lancaster JR Jr. (1999) Cellular antioxidant and pro-oxidant actions of nitric oxide. Free Rad Biol Med 27:1357-66.
19. Jousilahti P, Rastenyte D, Tuomilehto J. (2000) Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke. Stroke 31:1851-5.
20. Kong W, Wei J, Abidi P, et al. (2004) Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 10:1344-51.
21. Kosaraju J, Chinni S, Roy PD, et al. (2014) Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism. Indian J Pharmacol 46:176.
22. Lee JH, Kim SC, Kim KH, et al. (2014) Decreased cellular levels of palmitic amide are linked to 5-fluorouracil resistance in human colon cancer cells. Hepatogastroenterology 61:343-8.
23. Litten RZ, Bradley AM, Moss HB. (2010) Alcohol biomarkers in applied settings: recent advances and future research opportunities. Alcohol Clin Exp Res 34:955-67.
24. Liu G, HeW, Cai H, et al. (2014) The simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine in rat plasma by LC-MS/MS and a pharmacokinetic comparison after the oral administration of Rhizoma coptidis and Jiao-Tai-Wan extract. Anal Methods 6:2998-3008.
25. Loftus N, Barnes A, Ashton S, et al. (2010) Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res 10:705-13.
26. Maccioni P, Vargiolu D, Falchi M, et al. (2014) Reducing effect of the Chinese medicinal herb, Salvia miltiorrhiza, on alcohol self-administration in Sardinian alcohol-preferring rats. Alcohol 48:587-93.
27. Maha A, Agarwal KS, Alqudah M, et al. (2013) Tyrosyl DNA phosphodiesterase I is a prognostic factor and its inhibition synergizes response to topoisomerase poisons in malignant glioma. Cancer Res 73:2194.
28. Mahadevan S, Shah SL, Marrie TJ, et al. (2008) Analysis of metabolomic data using support vector machines. Anal Chem 80:7562-70.
29. Mak S, Luk WW, Cui W, et al. (2014) Synergistic inhibition on acetylcholinesterase by the combination of berberine and oalmatine originally isolated from Chinese medicinal herbs. J Mol Neurosci 53:511-6.
30. Manna SK, Patterson AD, Yang Q, et al. (2011) UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Prot Res 10:4120-33.
31. Mihas AA, Tavassoli M. (1992) Laboratory markers of ethanol intake and abuse: a critical appraisal. Am J Med Sci 303:415-28.
32. Mikosch P, Marksteiner J. (2014) Alcohol induced disorders. Wien Med Wochenschr 164:1-2.
33. Nanji AA, Greenberg SS, Tahan SR, et al. (1995) Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Gastroenterology 109:899-907.
34. Pomerleau OF, Rosecrans J. (1989) Neuroregulatory effects of nicotine. Psychoneuroendocrinol 14:407-23.
35. Puranik N, Sak K, Bidare C, et al. (2014) Protein anabolic and antihyperglycemic activity of Tinospora cordifolia (Willd.) in experimental diabetes mellitus: its efficacy in comparison with novel drug insulin. Res Rev: J Med Health Sci 3:82-6.
36. Racine SX, Le Toumelin P, Adnet F, et al. (2004) N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and glycopeptide antibiotic therapy. Nephron Physiol 97:53-7.
37. Ray LA, Chin PF, Miotto K. (2010) Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics. CNS Neurol Disord Drug Targets 9:13-22.
38. Reynolds K, Lewis B, Nolen JDL, et al. (2003) Alcohol consumption and risk of stroke: a meta-analysis. JAMA 289:579-88.
39. Sano H, Suzuki Y, Ohara K, et al. (1992) Circadian variation in plasma homovanillic acid level during and after alcohol withdrawal in alcoholic patients. Alcohol Clin Exp Res 16:1047-51.
40. Schroeder RL, Stevens CL, Sridhar J. (2014) Small molecule tyrosine kinase inhibitors of ErbB2/HER2/Neu in the treatment of aggressive breast cancer. Molecules 19:15196-212.
41. Shirolkar A, Gahlaut A, Hooda V, et al. (2013) Phytochemical composition changes in untreated stem juice of Tinospora cordifolia (W) Mier during refrigerated storage. J Pharm Res 7:1-6.
42. Song T, Zhang KY, Lao L, et al. (2014) Simultaneous determination of berberine and palmatine in human plasma and in urine by capillary electrophoresis combined with polypropylene hollow fiber liquid-liquid-liquid microextraction. Anal Methods 6:7928-34.
43. Spinozzi S, Colliva C, Camborata C, et al. (2014) Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects. J Nat Prod 77:766-72.
44. Stroes E, Kastelein J, Cosentino F, et al. (1997) Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 99:41-6. Supuran CT. (2013) Carbonic anhydrase inhibitors: an editorial. Expert Opin Ther Pat 23:677-9.
45. Supuran CT. (2013) Carbonic anhydrase inhibitors: an editorial. Expert Opin Ther Pat 23:677-9
46. Tiwari M, Dwivedi UN, Kakkar P. (2014) Tinospora cordifolia extract modulates COX-2, iNOS, ICAM-1, pro-inflammatory cytokines and redox status in murine model of asthma. J Ethnopharmacol 153:326-37.
47. Valenzuela CF. (1997) Alcohol and neurotransmitter interactions. Alcohol Health Res World 21:144-8.
48. Weiss F, Parsons LH, Schulteis G, et al. (1996) Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci 16:3474-85.
49. Wurst FM, Wiesbeck GA,Metzger JW, et al. (2004) On sensitivity, specificity, and the influence of various parameters on ethyl glucuronide levels in urine-results from the WHO/ISBRA study. Alcohol Clin Exp Res 28:1220-8.
50. Zindel LR, Kranzler HR. (2014) Pharmacotherapy of alcohol use disorders: seventy-five years of progress. J Stud Alcohol Drugs Suppl 17:79.