Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats

Phytomedicine

Volumn 21, Issue 7, 2014, Pages 966-969

  Antonisamy, Paulrayer ^a   Dhanasekaran, Muniyappan ^b   Ignacimuthu, Savarimuthu ^b   Duraipandiyan, Veeramuthu ^c   Balthazar, Joseph Devadass ^b   Agastian, Paul ^b   Kim, Jong Hoon ^a  

^a Chonbuk National University   (South Korea)

^b LOYOLA COLLEGE   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antiulcer; Epoxy clerodane diterpene; Gastric ulcer; Tinospora cordifolia; Ulcer index

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ANTIULCER AGENT; CASPASE 3; CELECOXIB; DITERPENE; EPOXY CLERODANE DITERPENE; GROWTH FACTOR; INDOMETACIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OMEPRAZOLE; PROSTAGLANDIN E2; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; (5R,10R)-4R,8R-DIHYDROXY-2S,3R:15,16-DIEPOXYCLERODA-13(16),17,12S:18,1S-DILACTONE; CLERODANE DERIVATIVE; CYTOKINE; ENZYME INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTECTIVE AGENT; PYRAZOLE DERIVATIVE;

ACUTE TOXICITY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH PROTECTION; STOMACH ULCER; TINOSPORA CORDIFOLIA; ULCER HEALING; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; STOMACH MUCOSA; TINOSPORA; TOXICITY TESTING; WISTAR RAT;

RATTUS; TINOSPORA CORDIFOLIA;

ANIMALS; CYCLOOXYGENASE INHIBITORS; CYTOKINES; DINOPROSTONE; DITERPENES, CLERODANE; ENZYME INHIBITORS; FEMALE; GASTRIC MUCOSA; INDOMETHACIN; MALE; NG-NITROARGININE METHYL ESTER; PROTECTIVE AGENTS; PYRAZOLES; RATS, WISTAR; STOMACH ULCER; TINOSPORA; TOXICITY TESTS, ACUTE;

EID: 84901621724     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.02.010     Document Type: Article

References (20)

1. E. Adami, E. Marzi-ubertti, and C. Turba Pharmacological research of gefarnate, a new synthetic isoprenoid with an anti- ulcer action Archives Internationales de Pharmacodynamie et de Therapie 147 1964 113 145
2. C.K. Atal, M.L. Sharma, A. Kaul, and A. Khajuria Immunomodulating agents of plant origin. Preliminary screening Journal of Ethnopharmacology 18 1986 133 141
3. Y.R. Chadha The Wealth of India vol. 10 1976 Publication and Information Directorate. CSIR New Delhi 251
4. S. Cuzzocrea, and D. Salvemini Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes Kidney International 71 2007 290 297
5. M. Dhanasekaran, A. Albert Baskar, S. Ignacimuthu, P. Agastian, and V. Duraipandiyan Chemopreventive potential of epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma Investigatonal New Drugs 27 2008 347 355
6. O. Dormond, M. Bezzi, A. Mariotti, and A.S. Ruegg Cyclooxygenase-2 implications on maintenance of gastric mucosal integrity and ulcer healing: controversies and perspectives Gut 49 2001 443 453
7. P.A. Gladding, M.W.I. Webster, H.B. Farrell, I.S.L. Zeng, R. Park, and N. Ruijne The antiplatelet effect of six nonsteroidal anti-inflammatory drugs and their pharmacodynamics interaction with aspirin in healthy volunteers American Journal of Cardiology 101 2008 1060 1063
8. C.M. Hogaboam, E.Y. Bissonnette, B.C. Chin, A.D. Befus, and J.L. Wallace Prostaglandins inhibit inflammatory mediator release from rat mast cells Gastroenterology 104 1993 122 129
9. G.C. Jagetia, V. Nayak, and M.S. Vidyasagar Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells Cancer Letters 127 1998 71 82
10. A. Lanas, M.A. Perez-Aisa, F. Feu, J. Ponce, E. Saperas, S. Santolaria, L. Rodrigo, J. Balanzo, E. Bajador, P. Almela, J.M. Navarro, F. Carballo, M. Castro, and E. Quintero A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use American Journal of Gastroenterology 100 2005 1685 1693
11. H. Morita, M. Nakayama, H. Kojima, K. Takeya, H. Itokawa, E.P. Schenkel, and M. Motidome Structures and cytotoxic activity relationship of Casearins, New Clerodane Diterpenes from Casearia sylvestris Sw Chemical and Pharmaceutical Bulletin 39 1991 693 697
12. D.N.K. Sarma, R.L. Khosa, J.P.N. Chansouria, and M. Sahai Antiulcer activity of Tinospora cordifolia Miers and Centella asiatica Linn extracts Phytotherapy Research 9 1995 589 590
13. B.L. Slomiany, J. Piotrowski, and A. Slomiany Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: effect of antiulcer agents Scandinavian Journal of Gastroenterology 34 1999 459 464
14. B.L. Slomiany, and A. Slomiany Nitric oxide as a modulator of gastric mucin synthesis: role of ERK and p38 mitogen activated protein kinase activation IUBMB Life 54 2002 267 273
15. B.L. Slomiany, and A. Slomiany Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis IUBMB Life 56 2004 41 46
16. P. Stordeur, and M. Goldman Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects International Reviews of Immunology 16 1998 501 522
17. K. Suzuki, H. Ota, and S. Sasagawa Assay method for myeloperoxidase in human polymorphonuclear leukocytes Analytical Biochemistry 132 1983 345 352
18. S. Vedavathy, and K.N. Rao Antipyretic activity of six indigenous medicinal plants of Tirumala Hills Andhra Pradesh, India Journal of Ethnopharmacology 33 1991 1 2
19. D. Wallach Cell death induction by TNF: a matter of self control Trends in Biochemical Sciences 22 1997 107 109
20. G.B. West Testing for drugs inhibiting the formation of gastric ulcers Journal of Pharmacological Methods 8 1982 33 37