The molecular phenotype of endocapillary proliferation: Novel therapeutic targets for IgA nephropathy

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Hodgin, Jeffrey B ^a   Berthier, Celine C ^a   John, Rohan ^b,f   Grone, Elisabeth ^c   Porubsky, Stefan ^c,d   Gron̈e, Hermann Josef ^c   Herzenberg, Andrew M ^b,f   Scholey, James W ^b   Hladunewich, Michelle ^b,e   Cattran, Daniel C ^b   Kretzler, Matthias ^a   Reich, Heather N ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CORTICOSTEROID; HYDROQUININE; MESSENGER RNA; RESVERATROL; TRANSCRIPTOME;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MICROARRAY ANALYSIS; MICRODISSECTION; PHENOTYPE; SCORING SYSTEM; COMPUTER SIMULATION; DRUG SCREENING; GLOMERULONEPHRITIS, IGA; GLOMERULUS; METABOLISM; MIDDLE AGED; MOLECULARLY TARGETED THERAPY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; VASCULARIZATION; YOUNG ADULT;

ADRENAL CORTEX HORMONES; ADULT; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; FEMALE; GLOMERULONEPHRITIS, IGA; HUMANS; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; MOLECULAR TARGETED THERAPY; NEOVASCULARIZATION, PATHOLOGIC; PHENOTYPE; TRANSCRIPTOME; YOUNG ADULT;

EID: 84929138298     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103413     Document Type: Article

References (32)

1. Bartosik LP, Lajoie G, Sugar L, Cattran DC (2001) Predicting progression in IgA nephropathy. American Journal of Kidney Diseases 38: 728-735.
2. Barratt J, Feehally J (2005) IgA nephropathy. Journal of the American Society of Nephrology 16: 2088-2097. (Pubitemid 41716440)
3. Roberts IS, Cook HT, Troyanov S, Alpers CE, Amore A, et al. (2009) The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney International.
4. Cattran DC, Coppo R, Cook HT, Feehally J, Roberts IS, et al. (2009) The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney International.
5. Herzenberg AM, Fogo AB, Reich HN, Troyanov S, Bavbek N, et al. (2011) Validation of the Oxford classification of IgA nephropathy. Kidney International 80: 310-317.
6. El Karoui K, Hill GS, Karras A, Moulonguet L, Caudwell V, et al. (2011) Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies. Kidney international 79: 643-654.
7. Lee H, Yi SH, Seo MS, Hyun JN, Jeon JS, et al. (2012) Validation of the Oxford classification of IgA nephropathy: a single-center study in Korean adults. The Korean journal of internal medicine 27: 293-300.
8. Edstrom HS, Soderberg MP, Berg UB (2012) Predictors of outcome in paediatric IgA nephropathy with regard to clinical and histopathological variables (Oxford classification). Nephrology, Dialysis, Transplantation 27: 715-722.
9. Shi SF, Wang SX, Jiang L, Lv JC, Liu LJ, et al. (2011) Pathologic predictors of renal outcome and therapeutic efficacy in IgA nephropathy: validation of the oxford classification. ClinJAmSocNephrol 6: 2175-2184.
10. Zeng CH, Le W, Ni Z, Zhang M, Miao L, et al. (2012) A multicenter application and evaluation of the oxford classification of IgA nephropathy in adult chinese patients. American journal of kidney diseases : the official journal of the National Kidney Foundation 60: 812-820.
11. Roberts IS (2013) Oxford classification of immunoglobulin A nephropathy: an update. Current opinion in nephrology and hypertension 22: 281-286.
12. Hotta O, Furuta T, Chiba S, Tomioka S, Taguma Y (2002) Regression of IgA nephropathy: a repeat biopsy study. American journal of kidney diseases : the official journal of the National Kidney Foundation 39: 493-502.
13. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS, Jr. (1995) Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270: 283-286.
14. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M (1995) Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270: 286-290.
15. Cohen CD, Frach K, Schlondorff D, Kretzler M (2002) Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. Kidney International 61: 133-140. (Pubitemid 34075139)
16. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, 3rd, et al. (2009) A new equation to estimate glomerular filtration rate. Annals of internal medicine 150: 604-612.
17. Schmid H, Henger A, Kretzler M (2006) Molecular approaches to chronic kidney disease. Current opinion in nephrology and hypertension 15: 123-129.
18. Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-193. (Pubitemid 36181903)
19. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, et al. (2006) TM4 microarray software suite. Methods in enzymology 411: 134-193.
20. Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, et al. (2006) The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313: 1929-1935. (Pubitemid 44497995)
21. Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, et al. (2010) An atlas of combinatorial transcriptional regulation in mouse and man. Cell 140: 744-752.
22. Lv J, Xu D, Perkovic V, Ma X, Johnson DW, et al. (2012) Corticosteroid therapy in IgA nephropathy. Journal of the American Society of Nephrology : JASN 23: 1108-1116.
23. Coppo R, Basolo B, Piccoli G, Mazzucco G, Bulzomi MR, et al. (1984) IgA1 and IgA2 immune complexes in primary IgA nephropathy and Henoch-Schonlein nephritis. Clinical and experimental immunology 57: 583-590. (Pubitemid 14057714)
24. Gesualdo L, Lamm ME, Emancipator SN (1990) Defective oral tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization. Journal of immunology 145: 3684-3691.
25. Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397. (Pubitemid 27334820)
26. Coppo R, Amore A, Peruzzi L, Vergano L, Camilla R (2010) Innate immunity and IgA nephropathy. Journal of nephrology 23: 626-632.
27. Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annual review of immunology 21: 335-376. (Pubitemid 37174535)
28. Butte AJ, Ito S (2012) Translational bioinformatics: data-driven drug discovery and development. Clinical pharmacology and therapeutics 91: 949-952.
29. Zhong Y, Chen EY, Liu R, Chuang PY, Mallipattu SK, et al. (2013) Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase. Journal of the American Society of Nephrology : JASN 24: 801-811.
30. Giovannini L, Migliori M, Longoni BM, Das DK, Bertelli AA, et al. (2001) Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys. Journal of cardiovascular pharmacology 37: 262-270. (Pubitemid 32193504)
31. Wen D, Huang X, Zhang M, Zhang L, Chen J, et al. (2013) Resveratrol attenuates diabetic nephropathy via modulating angiogenesis. PloS one 8: e82336.
32. Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, et al. (2010) Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer research 70: 9003-9011.