Innate immunity and IgA nephropathy

Journal of Nephrology

Volumn 23, Issue 6, 2010, Pages 626-632

  Coppo, Rosanna ^a   Amore, Alessandro ^a   Peruzzi, Licia ^a   Vergano, Luca ^a   Camilla, Roberta ^a  

^a Regina Margherita Children's University Hospital   (Italy)

Author keywords

Aberrantly glycosylated IgA; Complement; IgA nephropathy; Innate immunity; Pathogenesis; Toll like receptors

Indexed keywords

BACTERIAL ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN A; PROPERDIN; TOLL LIKE RECEPTOR; VIRUS ANTIGEN;

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; COMPLEMENT ACTIVATION; DENDRITIC CELL; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN DEPOSITION; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INNATE IMMUNITY; KIDNEY CELL; LEUKOCYTE FUNCTION; MACROPHAGE FUNCTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MUCOSAL IMMUNITY; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; REVIEW; SENDAI VIRUS INFECTION; T LYMPHOCYTE ACTIVATION; VIRUS PATHOGENESIS;

ANIMALS; COMPLEMENT ACTIVATION; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNITY, INNATE; IMMUNITY, MUCOSAL; MICE; TOLL-LIKE RECEPTORS;

EID: 78549289219     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

1. Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22:240-273.
2. Rasmussen SB, Reinert LS, Paludan SR. Innate recognition of intracellular pathogens: detection and activation of the first line of defense. APMIS. 2009;117:323-337.
3. Mellanby RJ, Thomas DC, Lamb J. Role of regulatory T-cells in autoimmunity. Clin Sci (Lond). 2009;116:639-649.
4. Kim HS, Lee MS. Role of innate immunity in triggering and tuning of autoimmune diabetes. Curr Mol Med. 2009;9:30-44.
5. Kawai T, Akira S, Ann NY. Toll-like receptor and RIG-I-like receptor signaling. Acad Sci. 2008;1143:1-20.
6. Bowie AG, Haga IR. The role of Toll-like receptors in the host response to viruses. Mol Immunol. 2005;42:859-867. (Pubitemid 40489009)
7. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335-376.
8. Anders HJ, Schlöndorff D. Toll-like receptors: emerging concepts in kidney disease. Curr Opin Nephrol Hypertens. 2007;16:177-183. (Pubitemid 46608524)
9. Patole PS, Zecher D, Pawar RD, Gröne HJ, Schlöndorff D, Anders HJ. G-rich DNA suppresses systemic lupus. J Am Soc Nephrol. 2005;16:3273-3280. (Pubitemid 46187549)
10. Brown HJ, Sacks SH, Robson MG. Toll-like receptor 2 ago nists exacerbate accelerated nephrotoxic nephritis. J Am Soc Nephrol. 2006;17:1931-1939.
11. Schena FP, Coppo R. IgA nephropathies. In: Davison AM, Ritz E, Cameron JS, Winearls C, eds. Oxford textbook of clinical nephrology. 3rd ed. Oxford: Oxford University Press; 2005.
12. Valentijn RM, Radl J, Haaijman JJ, et al. Circulating and mesangial secretory component-binding IgA-1 in primary IgA nephropathy. Kidney Int. 1984;26:760-766. (Pubitemid 15216149)
13. Coppo R, Basolo B, Piccoli G, et al. IgA1 and IgA2 immune complexes in primary IgA nephropathy and Henoch-Schönlein nephritis. Clin Exp Immunol. 1984;57:583-590. (Pubitemid 14057714)
14. Valentijn RM, Kauffmann RH, de la Rivière GB, et al. Presence of circulating macromolecular IgA in patients with hematuria due to primary IgA nephropathy. Am J Med. 1983;74:375-381.
15. Coppo R, Amore A. Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int. 2004;65:1544-1547. (Pubitemid 38590997)
16. Smith AC, Molyneux K, Feehally J, Barratt J. O-Glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol. 2006;17:3520-3528. (Pubitemid 44865295)
17. Hiki Y, Horii A, Iwase H, et al. O-Linked oligosaccharide on IgA1 hinge region in IgA nephropathy: fundamental study for precise structure and possible role. Contrib Nephrol. 1995;111:73-84.
18. Kerr MA. The structure and function of human IgA. Biochem J. 1990;271:285-296.
19. Tarelli E, Smith AC, Hendry BM, Challacombe SJ, Pouria S. Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry. Carbohydr Res. 2004;339:2329-2335. (Pubitemid 39165126)
20. Allen AC, Bailey EM, Barratt J, Buck KS, Feehally J. Analysis of IgA1 O-glycans in IgA nephropathy by fluorophore-assisted carbohydrate electrophoresis. J Am Soc Nephrol. 1999;10:1763-1771. (Pubitemid 29364675)
21. Coppo R, Amore A, Gianoglio B, et al. Serum IgA and macromolecular IgA reacting with mesangial matrix components. Contrib Nephrol. 1993;104:162-171.
22. Wyatt RJ, Julian BA. Activation of complement in IgA nephropathy. Am J Kidney Dis. 1988;12:437-442.
23. Shinohara H, Nagi-Miura N, Ishibashi K, et al. Beta-mannosyl linkages negatively regulate anaphylaxis and vasculitis in mice, induced by CAWS, fungal PAMPS composed of mannoprotein- beta-glucan complex secreted by Candida albicans. Biol Pharm Bull. 2006;29:1854-1861. (Pubitemid 44338407)
24. Roos A, Rastaldi MP, Calvaresi N, et al. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol. 2006;17:1724-1734.
25. Emancipator SN, Gallo GR, Lamm ME. Experimental IgA nephropathy induced by oral immunization. J Exp Med. 1983;157:572-582. (Pubitemid 13145060)
26. Coppo R, Mazzucco G, Martina G, et al. Gluten-induced experimental IgA glomerulopathy. Lab Invest. 1989;60:499-506.
27. Russell MW, Mestecky J, Julian BA, Galla JH. Detection of antigenic substances in patients with IgA nephropathy. J Clin Immunol. 1986;6:74-86.
28. Tomino Y, Sakai H, Miura M, Nomoto Y, Umehara K, Hashimoto K. IgA-associated renal diseases: antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruli. Contrib Nephrol. 1984;40:69-73.
29. Harper SJ, Allen AC, Pringle JH, Feehally J. Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA. J Clin Pathol. 1996;49:38-42. (Pubitemid 26037051)
30. de Fijter JW, Eijgenraam JW, Braam CA, et al. Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy. Kidney Int. 1996;50:952-961.
31. Buck KS, Smith AC, Molyneux K, El-Barbary H, Feehally J, Barratt J. B-cell O-galactosyltransferase activity, and expression of O-glycosylation genes in bone marrow in IgA nephropathy. Kidney Int. 2008;73:1128-1136. (Pubitemid 351620426)
32. Gesualdo L, Lamm ME, Emancipator SN. Defective oral tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization. J Immunol. 1990;145:3684-3691.
33. Weisz-Carrington P, Grimes SR Jr, Lamm ME. Gut-associated lymphoid tissue as source of an IgA immune response in respiratory tissues after oral immunization and intrabronchial challenge. Cell Immunol. 1987;106:132-138. (Pubitemid 17064342)
34. Yan D, Rumbeiha WK, Pestka JJ. Experimental murine IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies. Food Chem Toxicol. 1998;36:1095-1106. (Pubitemid 29002892)
35. Kai H, Shimizu Y, Hagiwara M, et al. Post-MRSA infection glomerulonephritis with marked Staphylococcus aureus cell envelope antigen deposition in glomeruli. J Nephrol. 2006;19:215-219. (Pubitemid 44420115)
36. Satoskar AA, Nadasdy G, Plaza JA, et al. Staphylococcus infection-associated glomerulonephritis mimicking IgA nephropathy. Clin J Am Soc Nephrol. 2006;1:1179-1186.
37. Yamamoto C, Suzuki S, Kimura H, Yoshida H, Gejyo F. Experimental nephropathy induced by Haemophilus parainfluenzae antigens. Nephron. 2002;90:320-327. (Pubitemid 34195759)
38. Cioc AM, Sedmak DD, Nuovo GJ, Dawood MR, Smart G, Magro CM. Parvovirus B19 associated adult Henoch Schönlein purpura. J Cutan Pathol. 2002;29:602-607. (Pubitemid 36001995)
39. Jessen RH, Emancipator SN, Jacobs GH, Nedrud JG. Experimental IgA-IgG nephropathy induced by a viral respiratory pathogen: dependence on antigen form and immune status. Lab Invest. 1992;67:379-386.
40. Amore A, Coppo R, Nedrud JG, Sigmund N, Lamm ME, Emancipator SN. The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus. Clin Immunol. 2004;113:101-108. (Pubitemid 39468273)
41. Sharmin S, Shimizu Y, Hagiwara M, Hirayama K, Koyama A. Staphylococcus aureus antigens induce IgA-type glomerulonephritis in Balb/c mice. J Nephrol. 2004;17:504-511. (Pubitemid 39302877)
42. Wang J, Anders RA, Wu Q, et al. Dysregulated LIGHT expres sion on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest. 2004;113:826-835. (Pubitemid 38544141)
43. Suzuki H, Suzuki Y, Narita I, et al. Toll-like receptor 9 affects severity of IgA nephropathy. J Am Soc Nephrol. 2008;19:2384-2395.
44. Coppo R, Camilla R, Amore A, et al. Toll-like receptor 4 expression is increased in circulating mononuclear cells of patients with immunoglobulin A nephropathy. Clin Exp Immunol. 2009; Epub ahead of print.
45. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335-376.
46. Brown HJ, Lock HR, Wolfs TG, et al. Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody- mediated glomerulonephritis via CXCL1 and CXCL2. J Am Soc Nephrol. 2007;18:1732-1739.
47. Yoon HJ, Shin JH, Yang SH, et al. Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. J Med Genet. 2003;40:104-108. (Pubitemid 36232814)
48. McCarthy DD, Chiu S, Gao Y, et al. BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT. Cell Immunol. 2006;241:85-94. (Pubitemid 44649295)
49. Yuling H, Ruijing X, Xiang J, et al. CD19+CD5+ B cells in primary IgA nephropathy. J Am Soc Nephrol. 2008;19:2130-2139.
50. Goto T, Bandoh N, Yoshizaki T, et al. Increase in B-cell-activation factor (BAFF) and IFN-gamma productions by tonsillar mononuclear cells stimulated with deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) in patients with IgA nephropathy. Clin Immunol. 2008;126:260-269.
51. Inoue T, Sugiyama H, Kikumoto Y, et al. Downregulation of the beta1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy. Contrib Nephrol. 2007;157:120-124.
52. Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyl-transferase. Proc Natl Acad Sci U S A. 2002;99:16613-16618. (Pubitemid 36034021)
53. Qin W, Zhong X, Fan JM, et al. External suppression causes the low expression of the Cosmc gene in IgA nephropathy. Nephrol Dial Transplant. 2008;23:1608-1614. (Pubitemid 351767729)
54. Cederholm D, Wieslander J, Bygren NP, et al. Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy. Proc Natl Acad Sci U S A. 1988;88:4865-4868.