Alterations in the blood-spinal cord barrier in TDP-43 conditional knockout mice

Neuroscience Letters

Volumn 598, Issue , 2015, Pages 1-5

  Sasaki, Shoichi ^a   Iguchi, Yohei ^b   Katsuno, Masahisa ^b   Sobue, Gen ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amyotrophic lateral sclerosis; Blood spinal cord barrier; Fibrinogen; TDP 43 knockout mice; Tight junction proteins; Ultrastructure

Indexed keywords

FIBRINOGEN; TAR DNA BINDING PROTEIN; TIGHT JUNCTION PROTEIN; DNA BINDING PROTEIN; GALECTIN 3; TDP-43 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SPINAL CORD BARRIER; CELL VACUOLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; INVESTIGATIVE PROCEDURES; KNOCKOUT MOUSE; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PERICYTE; PERMEABILITY BARRIER; PRIORITY JOURNAL; SPINAL CORD FUNCTION; SPINAL CORD VENTRAL HORN; TIGHT JUNCTION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CAPILLARY; CAPILLARY PERMEABILITY; GENETICS; MACROPHAGE; METABOLISM; MICROGLIA; SPINAL CORD; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; CAPILLARIES; CAPILLARY PERMEABILITY; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FIBRINOGEN; GALECTIN 3; MACROPHAGES; MICE, KNOCKOUT; MICROGLIA; MOTOR NEURONS; SPINAL CORD;

EID: 84929089977     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.05.005     Document Type: Article

References (24)

1. Bartanusz V., Jezova D., Alajajian B., Digicaylioglu M. The blood-spinal cord barrier: morphology and clinical implications. Ann. Neurol. 2011, 70:194-206.
2. Garbuzova-Davis S., Sanberg P.R. Blood-CNS barrier impairment in ALS patients versus an animal model. Front. Cell. Neurosci. 2014, 10.3389/fncel.2014.00021.
3. Iguchi Y., Katsuno M., Niwa J., Takagi S., Ishigaki S., Ikenaka K., Kawai K., Watanabe H., Yamanaka K., Takahashi R., Misawa H., Sasaki S., Tanaka F., Sobue G. Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain 2013, 136:1371-1382.
4. Alexianu M.E., Kozovska M., Appel S.H. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 2001, 57:1282-1289.
5. Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
6. Leonardi A., Abbruzzese G., Arata L., Cocito L., Vische M. Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis. J. Neurol. 1984, 231:75-78.
7. Annunziata P., Volpi N. High levels of C3c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients. Acta Neurol. Scand. 1985, 72:61-64.
8. Brettschneider J., Petzold A., Süssmuth S.D., Ludolph A.C., Tumani H. Axonal damage markers in cerebrospinal fluid are increased in ALS. Neurology 2006, 66:852-856.
9. Zhong Z., Deane R., Ali Z., Parisi M., Shapovalov Y., O'Banion M.K., Stojanovic K., Sagare A., Boillee S., Cleveland D.W., Zlokovic B.V. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat. Neurosci. 2008, 11:420-422.
10. Engelhardt J.I., Tajti J., Appel S.H. Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch. Neurol. 1993, 50:30-36.
11. Henkel J.S., Engelhardt J.I., Siklos L., Simpson E.P., Kim S.H., Pan T., Goodman J.C., Siddique T., Beers D.R., Appel S.H. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann. Neurol. 2004, 55:221-235.
12. Garbuzova-Davis S., Saporta S., Haller E., Kolomey I., Bennett S.P., Potter H., Sanberg P.R. Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS. PLoS ONE 2007, 2:e1205.
13. Nicaise C., Mitrecic D., Demetter P., De Decker R., Authelet M., Boom A., Pochet R. Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat. Brain Res. 2009, 1301:152-162.
14. Regan R.F., Guo Y. Toxic effect of hemoglobin on spinal cord neurons in culture. J. Neurotrauma 1998, 15:645-653.
15. Garbuzova-Davis S., Haller E., Saporta S., Kolomey I., Nicosia S.V., Sanberg P.R. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain Res. 2007, 1157:126-137.
16. Winkler E.A., Sengillo J.D., Sullivan J.S., Henkel J.S., Appel S.H., Zlokovic B.V. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol. 2013, 125:111-120.
17. Dallasta L.M., Pisarov L.A., Esplen J.E., Werley J.V., Moses A.V., Nelson J.A., Achim C.L. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 1999, 155:1915-1927.
18. Luabeya M.K., Dallasta L.M., Achim C.L., Pauza C.D., Hamilton R.L. Blood-brain barrier disruption in simian immunodeficiency virus encephalitis. Neuropathol. Appl. Neurobiol. 2000, 26:454-462.
19. Henkel J.S., Beers D.R., Wen S., Bowser R., Appel A.H. Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS. Neurology 2009, 72:1614-1616.
20. Liebner S., Fischmann A., Rascher G., Duffner F., Grote E.-H., Kakbacher H., Wolburg H. Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastomamultiforme. Acta Neuropathol. 2000, 100:323-331.
21. Winkler E.A., Sengillo J.D., Bell R.D., Wang J., Zlokovic B.V. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J. Cereb. Blood Flow Metab. 2012, 32:1841-1852.
22. Kalaria R.N., Cohen D.L., Premkumar D.R., Nag S., LaManna J.C., Lust W.D. Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia. Brain Res. Mol. Brain Res. 1998, 62:101-105.
23. Liao B., Zhao W., Beers D.R., Henkel J.S., Appel S.H. Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS. Exp. Neurol. 2012, 237:147-152.
24. Fischer S., Wobben M., Kleinstück J., Renz D., Schaper W. Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells. Am. J. Physiol. Cell Physiol. 2000, 279:C935-944.