Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease

European Journal of Preventive Cardiology

Volumn 22, Issue 6, 2015, Pages 743-752

  Svingen, Gard F T ^a   Schartum Hansen, Hall ^a,b   Ueland, Per M ^a,b   Pedersen, Eva R ^a   Seifert, Reinhard ^b   Ebbing, Marta ^c   Bønaa, Kaare H ^d   Mellgren, Gunnar ^a,b,e   Nilsen, Dennis W T ^a,f   Nordrehaug, Jan E ^a   Øyen, Jannike ^a,b   Nygård, Ottar ^a,b,e  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e KG Jebsen Center for Diabetes Research   (Norway)

^f STAVANGER UNIVERSITY HOSPITAL   (Norway)

Author keywords

acute myocardial infarction; Angina pectoris; coronary heart disease; dimethylglycine; mortality

Indexed keywords

CHOLESTEROL; CREATININE; DIMETHYLGLYCINE; TROPONIN T; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; BHMT PROTEIN, HUMAN; BIOLOGICAL MARKER; SARCOSINE;

ACUTE HEART INFARCTION; AGE; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; GLOMERULUS FILTRATION RATE; HUMAN; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REPRODUCIBILITY; SEX DIFFERENCE; SMOKING; STABLE ANGINA PECTORIS; ANALOGS AND DERIVATIVES; ANGINA, STABLE; BLOOD; CLINICAL TRIAL; GENETIC PREDISPOSITION; GENETICS; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NORWAY; PHENOTYPE; PREDICTIVE VALUE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; TIME; UPREGULATION;

ANGINA, STABLE; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; BIOMARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINEAR MODELS; LOGISTIC MODELS; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; NORWAY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; SARCOSINE; TIME FACTORS; UP-REGULATION;

EID: 84929085695     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1177/2047487314529351     Document Type: Article

References (33)

1. Sparks JD, Collins HL, Chirieac DV, et al. Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Biochem J. 2006; 395: 363-371
2. Teng YW, Mehedint MG, Garrow TA, et al. Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem. 2011; 286: 36258-36267
3. Ueland PM. Choline and betaine in health and disease. J Inherit Metab Dis. 2011; 34: 3-15
4. Fuso A, Nicolia V, Cavallaro RA, et al. DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models. J Nutr Biochem. 2011; 22: 242-251
5. Duthie SJ. Epigenetic modifications and human pathologies: Cancer and CVD. Proc Nutr Soc. 2011; 70: 47-56
6. European guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur J Prev Cardiol. 2012; 19: 585-667
7. Svingen GF, Ueland PM, Pedersen EK, et al. Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris. Arterioscler Thromb Vasc Biol. 2013; 33: 2041-2048
8. Lever M, George PM, Elmslie JL, et al. Betaine and secondary events in an acute coronary syndrome cohort. PloS One. 2012; 7: e37883-e37883
9. Gallo V, Egger M, McCormack V, et al. STrengthening the Reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): An extension of the STROBE Statement. PLoS Med. 2011; 8: e1001117-e1001117
10. Ebbing M, Bleie O, Ueland PM, et al. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: A randomized controlled trial. JAMA. 2008; 300: 795-804
11. Bonaa KH, Njolstad I, Ueland PM, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006; 354: 1578-1588
12. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004; 27: 1487-1495
13. Koenker R Quantile regression. 1 st ed. New York, USA: Cambridge University Press, 2011, pp. 366-366. New York, USA: Cambridge University Press; 2011: 366-366.
14. Clarke GM, Anderson CA, Pettersson FH, et al. Basic statistical analysis in genetic case-control studies. Nat Protoc. 2011; 6: 121-133
15. Fredriksen A, Meyer K, Ueland PM, et al. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat. 2007; 28: 856-865
16. Pencina MJ, D'Agostino RB, Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med. 2011; 30: 11-21
17. Nygard O, Nordrehaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997; 337: 230-236
18. McGregor DO, Dellow WJ, Lever M, et al. Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001; 59: 2267-2272
19. Hamm CW, Bassand JP, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011; 32: 2999-3054
20. Chopra MP, Thadani U, Aber CP, et al. Plasma cortisol, urinary 17-hydroxycorticoids, and urinary vanilyl mandelic acid after acute myocardial infarction. Br Heart J. 1972; 34: 992-997
21. Shah B, Amoroso NS, Sedlis SP. Hyperglycemia in nondiabetic patients presenting with acute myocardial infarction. Am J Med Sci. 2012; 343: 321-326
22. Ratnam S, Wijekoon EP, Hall B, et al. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab. 2006; 290: E933-E939
23. Marenzi G, Cabiati A, Bertoli SV, et al. Incidence and relevance of acute kidney injury in patients hospitalized with acute coronary syndromes. Am J Cardiol. 2013; 111: 816-822
24. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: A collaborative meta-analysis. Lancet. 2010; 375: 2073-2081
25. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000; 80: 1107-213
26. Sheikh K, Camejo G, Lanne B, et al. Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. Am J Physiol Endocrinol Metab. 2007; 292: E1157-E1165
27. Sica DA. Fibrate therapy and renal function. Curr Atheroscler Rep. 2009; 11: 338-342
28. Omland T, de Lemos JA, Sabatine MS, et al. A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med. 2009; 361: 2538-2547
29. Kubli DA, Gustafsson AB. Mitochondria and mitophagy: The yin and yang of cell death control. Circ Res. 2012; 111: 1208-1221
30. Tibbetts AS, Appling DR. Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr. 2010; 30: 57-81
31. Wang Z, Tang WH, Buffa JA, et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J. 3 Feb 2014 [Epub ahead of print].
32. Cope EL, Shrubsole MJ, Cohen SS, et al. Intraindividual variation in one-carbon metabolism plasma biomarkers. Cancer Epidemiol Biomarkers Pev. 2013; 22: 1894-1899
33. Hustad S, Eussen S, Midttun O, et al. Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism. Clin Chem. 2012; 58: 402-410