Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule

European Journal of Pharmaceutical Sciences

Volumn 76, Issue , 2015, Pages 57-67

  Singh, Aastha ^a   Fatima, Kaneez ^a   Singh, Arjun ^a   Behl, Akansha ^b   Mintoo, M J ^b   Hasanain, Mohammad ^c   Ashraf, Raghib ^c   Luqman, Suaib ^a   Shanker, Karuna ^a   Mondhe, D M ^b   Sarkar, Jayanta ^c   Chanda, Debabrata ^a   Negi, Arvind S ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Anticancer; Benzylidene indanone; Caspase; Cell cycle; Ehrlich ascites carcinoma; Sub acute toxicity

Indexed keywords

3 (3',4',5' TRIMETHOXYPHENYL) 4,5,6 TRIMETHOXY 2 (3'',4' METHYLENEDIOXYBENZYLIDENE) INDAN 1 ONE; ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE; COLCHICINE; COMBRETASTATIN A4; DOXORUBICIN; FLUOROURACIL; INDANONE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLASMA PROTEIN; PODOPHYLLOTOXIN; TAMOXIFEN; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; 3-(3',4',5'-TRIMETHOXYPHENYL)-4,5,6-TRIMETHOXY,2-(3',4'-METHYLENEDIOXYBENZYLIDENE)INDAN-1-ONE; INDAN DERIVATIVE; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SIZE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG POTENCY; DRUG PURITY; DRUG SCREENING; DRUG STRUCTURE; EHRLICH ASCITES TUMOR; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; M PHASE CELL CYCLE CHECKPOINT; MALE; MCF 7 CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; SINGLE DRUG DOSE; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; BREAST NEOPLASMS; CARCINOMA, EHRLICH TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PATHOLOGY; TIME FACTOR; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZODIOXOLES; BREAST NEOPLASMS; CARCINOMA, EHRLICH TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INDANS; INHIBITORY CONCENTRATION 50; MALE; MCF-7 CELLS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; TIME FACTORS; TUMOR BURDEN;

EID: 84929072957     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.04.020     Document Type: Article

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