-
1
-
-
84897076939
-
Long-term safety and tolerability of prosavin a lentiviral vector-based gene therapy for parkinson's disease: A dose escalation open-label phase ' trial
-
Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, et al. (2014). Long-term safety and tolerability of ProSavin a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation open-label phase ' trial. Lancet 383: 1138-1146
-
(2014)
Lancet
, vol.383
, pp. 1138-1146
-
-
Palfi, S.1
Gurruchaga, J.M.2
Ralph, G.S.3
Lepetit, H.4
Lavisse, S.5
Buttery, P.C.6
-
2
-
-
84879086501
-
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients
-
Bartus RT, Baumann TL, Siffert J, Herzog CD, Alterman R, Boulis N, et al. (2013). Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. Neurology 80: 1698-1701
-
(2013)
Neurology
, vol.80
, pp. 1698-1701
-
-
Bartus, R.T.1
Baumann, T.L.2
Siffert, J.3
Herzog, C.D.4
Alterman, R.5
Boulis, N.6
-
3
-
-
79952740079
-
AAV2-GAD gene therapy for advanced Parkinson's disease: A double-blind sham-surgery controlled randomised trial
-
LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, et al. (2011). AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind sham-surgery controlled randomised trial. Lancet Neurol 10: 309-319
-
(2011)
Lancet Neurol
, vol.10
, pp. 309-319
-
-
Lewitt, P.A.1
Rezai, A.R.2
Leehey, M.A.3
Ojemann, S.G.4
Flaherty, A.W.5
Eskandar, E.N.6
-
4
-
-
78349247631
-
Gene delivery of AAV2-neurturin for Parkinson's disease: A double-blind randomised controlled trial
-
Marks WJ Jr, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, et al. (2010). Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind randomised controlled trial. Lancet Neurol 9: 1164-1172
-
(2010)
Lancet Neurol
, vol.9
, pp. 1164-1172
-
-
Marks, W.J.1
Bartus, R.T.2
Siffert, J.3
Davis, C.S.4
Lozano, A.5
Boulis, N.6
-
5
-
-
77956262279
-
A phase i study of aromatic l-amino acid decarboxylase gene therapy for parkinson's disease
-
Muramatsu S-I, Fujimoto K-I, Kato S, Mizukami H, Asari S, Ikeguchi K, et al. (2010). A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease. Mol Ther 18: 1731-1735
-
(2010)
Mol Ther
, vol.18
, pp. 1731-1735
-
-
Muramatsu, S.-I.1
Fujimoto, K.-I.2
Kato, S.3
Mizukami, H.4
Asari, S.5
Ikeguchi, K.6
-
6
-
-
73449128979
-
Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
-
Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, et al. (2009). Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology 73: 1662-1669
-
(2009)
Neurology
, vol.73
, pp. 1662-1669
-
-
Christine, C.W.1
Starr, P.A.2
Larson, P.S.3
Eberling, J.L.4
Jagust, W.J.5
Hawkins, R.A.6
-
7
-
-
0024802672
-
Experience with continuous enteral levodopa infusions in the treatment of 9 patients with advanced Parkinson's disease
-
discussion 72
-
Sage JI, Trooskin S, Sonsalla PK and Heikkila RE. (1989). Experience with continuous enteral levodopa infusions in the treatment of 9 patients with advanced Parkinson's disease. Neurology 39(11 Suppl 2): 60-3; discussion 72
-
(1989)
Neurology
, vol.39
, Issue.11 SUPPL2
, pp. 60-63
-
-
Sage, J.I.1
Trooskin, S.2
Sonsalla, P.K.3
Heikkila, R.E.4
-
8
-
-
0023937322
-
Long-term duodenal infusion of levodopa for motor fluctuations in parkinsonism
-
Sage JI, Trooskin S, Sonsalla PK, Heikkila R and Duvoisin RC. (1988). Long-term duodenal infusion of levodopa for motor fluctuations in parkinsonism. Ann Neurol 24: 87-89
-
(1988)
Ann Neurol
, vol.24
, pp. 87-89
-
-
Sage, J.I.1
Trooskin, S.2
Sonsalla, P.K.3
Heikkila, R.4
Duvoisin, R.C.5
-
9
-
-
0023627787
-
Motor fluctuations in Parkinson's disease: Pathogenetic and therapeutic studies
-
Mouradian MM, Juncos JL, Fabbrini G and Chase TN. (1987). Motor fluctuations in Parkinson's disease: pathogenetic and therapeutic studies. Ann Neurol 22: 475-479
-
(1987)
Ann Neurol
, vol.22
, pp. 475-479
-
-
Mouradian, M.M.1
Juncos, J.L.2
Fabbrini, G.3
Chase, T.N.4
-
10
-
-
0016587362
-
On-off response clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients
-
Shoulson I, Glaubiger GA and Chase TN. (1975). On-off response. Clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients. Neurology 25: 1144-1148
-
(1975)
Neurology
, vol.25
, pp. 1144-1148
-
-
Shoulson, I.1
Glaubiger, G.A.2
Chase, T.N.3
-
11
-
-
84865551695
-
Key factors determining the efficacy of gene therapy for continuous dopa delivery in the parkinsonian brain
-
Cederfjäll E, Sahin G and Kirik D. (2012). Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain. Neurobiol Dis 48: 222-227
-
(2012)
Neurobiol Dis
, vol.48
, pp. 222-227
-
-
Cederfjäll, E.1
Sahin, G.2
Kirik, D.3
-
12
-
-
15044365742
-
Reversal of dyskinesias in an animal model of parkinson's disease by continuous l-dopa delivery using raav vectors
-
Carlsson T, Winkler C, Burger C, Muzyczka N, Mandel RJ, Cenci A, et al. (2005). Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain 128(Pt 3): 559-569
-
(2005)
Brain
, vol.128
, Issue.PT3
, pp. 559-569
-
-
Carlsson, T.1
Winkler, C.2
Burger, C.3
Muzyczka, N.4
Mandel, R.J.5
Cenci, A.6
-
13
-
-
0037007106
-
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer
-
Kirik D, Georgievska B, Burger C, Winkler C, Muzyczka N, Mandel RJ, et al. (2002). Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. Proc Natl Acad Sci USA 99: 4708-4713
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4708-4713
-
-
Kirik, D.1
Georgievska, B.2
Burger, C.3
Winkler, C.4
Muzyczka, N.5
Mandel, R.J.6
-
14
-
-
0032101756
-
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human gtp-cyclohydrolase i in a rat model of parkinson's disease
-
Mandel RJ, Rendahl KG, Spratt SK, Snyder RO, Cohen LK and Leff SE. (1998). Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. J Neurosci 18: 4271-4284
-
(1998)
J Neurosci
, vol.18
, pp. 4271-4284
-
-
Mandel, R.J.1
Rendahl, K.G.2
Spratt, S.K.3
Snyder, R.O.4
Cohen, L.K.5
Leff, S.E.6
-
15
-
-
0026483508
-
Dopa-decarboxylation in the striata of rats with unilateral substantia nigra lesions
-
Kang UJ, Park DH, Wessel T, Baker H and Joh TH. (1992). Dopa-decarboxylation in the striata of rats with unilateral substantia nigra lesions. Neurosci Lett 147: 53-57
-
(1992)
Neurosci Lett
, vol.147
, pp. 53-57
-
-
Kang, U.J.1
Park, D.H.2
Wessel, T.3
Baker, H.4
Joh, T.H.5
-
16
-
-
0015922157
-
Immunohistochemical localization of aromatic l-amino acid decarboxylase (dopa decarboxylase) in central dopamine and 5-hydroxytryptamine nerve cell bodies of the rat
-
Hökfelt T, Fuxe K and Goldstein M. (1973). Immunohistochemical localization of aromatic L-amino acid decarboxylase (DOPA decarboxylase) in central dopamine and 5-hydroxytryptamine nerve cell bodies of the rat. Brain Res 53: 175-180
-
(1973)
Brain Res
, vol.53
, pp. 175-180
-
-
Hökfelt, T.1
Fuxe, K.2
Goldstein, M.3
-
17
-
-
77249179185
-
Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease
-
Björklund T, Carlsson T, Cederfjäll EA, Carta M and Kirik D. (2010). Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease. Brain 133(Pt 2): 496-511
-
(2010)
Brain
, vol.133
, Issue.PT2
, pp. 496-511
-
-
Björklund, T.1
Carlsson, T.2
Cederfjäll, E.A.3
Carta, M.4
Kirik, D.5
-
18
-
-
84863494448
-
Design of a single aav vector for coexpression of th and gch1 to establish continuous dopa synthesis in a rat model of parkinson's disease
-
Cederfjäll E, Sahin G, Kirik D and Björklund T. (2012). Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease. Mol Ther 20: 1315-1326
-
(2012)
Mol Ther
, vol.20
, pp. 1315-1326
-
-
Cederfjäll, E.1
Sahin, G.2
Kirik, D.3
Björklund, T.4
-
19
-
-
33748195107
-
A rapid reversible and tunable method to regulate protein function in living cells using synthetic small molecules
-
Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG and Wandless TJ. (2006). A rapid reversible and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126: 995-1004
-
(2006)
Cell
, vol.126
, pp. 995-1004
-
-
Banaszynski, L.A.1
Chen, L.C.2
Maynard-Smith, L.A.3
Ooi, A.G.4
Wandless, T.J.5
-
20
-
-
77956972260
-
A general chemical method to regulate protein stability in the mammalian central nervous system
-
Iwamoto M, Björklund T, Lundberg C, Kirik D and Wandless TJ. (2010). A general chemical method to regulate protein stability in the mammalian central nervous system. Chem Biol 17: 981-988
-
(2010)
Chem Biol
, vol.17
, pp. 981-988
-
-
Iwamoto, M.1
Björklund, T.2
Lundberg, C.3
Kirik, D.4
Wandless, T.J.5
-
21
-
-
84866995180
-
Destabilizing domains mediate reversible transgene expression in the brain
-
Tai K, Quintino L, Isaksson C, Gussing F and Lundberg C. (2012). Destabilizing domains mediate reversible transgene expression in the brain. PLoS One 7: e46269
-
(2012)
Plos One
, vol.7
, pp. e46269
-
-
Tai, K.1
Quintino, L.2
Isaksson, C.3
Gussing, F.4
Lundberg, C.5
-
22
-
-
84880302312
-
Continuous dopa synthesis from a single aav: Dosing and efficacy in models of parkinson's disease
-
Cederfjäll E, Nilsson N, Sahin G, Chu Y, Nikitidou E, Björklund T, et al. (2013). Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease. Sci Rep 3: 2157
-
(2013)
Sci Rep
, vol.3
, pp. 2157
-
-
Cederfjäll, E.1
Nilsson, N.2
Sahin, G.3
Chu, Y.4
Nikitidou, E.5
Björklund, T.6
-
23
-
-
84865567760
-
Regulated protein expression for in vivo gene therapy for neurological disorders: Progress strategies and issues
-
Manfredsson FP, Bloom DC and Mandel RJ. (2012). Regulated protein expression for in vivo gene therapy for neurological disorders: progress strategies and issues. Neurobiol Dis 48: 212-221
-
(2012)
Neurobiol Dis
, vol.48
, pp. 212-221
-
-
Manfredsson, F.P.1
Bloom, D.C.2
Mandel, R.J.3
-
24
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen M and Bujard H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89: 5547-5551
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
25
-
-
0033740246
-
Tetracycline-regulated gene expression in the brain
-
Mansuy IM and Bujard H. (2000). Tetracycline-regulated gene expression in the brain. Curr Opin Neurobiol 10: 593-596
-
(2000)
Curr Opin Neurobiol
, vol.10
, pp. 593-596
-
-
Mansuy, I.M.1
Bujard, H.2
-
26
-
-
65749097049
-
In vivo gene regulation using tetracycline-regulatable systems
-
Stieger K, Belbellaa B, Le Guiner C, Moullier P and Rolling F. (2009). In vivo gene regulation using tetracycline-regulatable systems. Adv Drug Deliv Rev 61: 527-541
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 527-541
-
-
Stieger, K.1
Belbellaa, B.2
Le Guiner, C.3
Moullier, P.4
Rolling, F.5
-
27
-
-
0032716172
-
Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease
-
Corti O, Sánchez-Capelo A, Colin P, Hanoun N, Hamon M and Mallet J. (1999). Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease. Proc Natl Acad Sci USA 96: 12120-12125
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12120-12125
-
-
Corti, O.1
Sánchez-Capelo, A.2
Colin, P.3
Hanoun, N.4
Hamon, M.5
Mallet, J.6
-
28
-
-
5644254312
-
Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum using a tetracycline-dependent lentiviral vector
-
Georgievska B, Jakobsson J, Persson E, Ericson C, Kirik D and Lundberg C. (2004). Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum using a tetracycline-dependent lentiviral vector. Hum Gene Ther 15: 934-944
-
(2004)
Hum Gene Ther
, vol.15
, pp. 934-944
-
-
Georgievska, B.1
Jakobsson, J.2
Persson, E.3
Ericson, C.4
Kirik, D.5
Lundberg, C.6
-
29
-
-
70449122321
-
Tight long-term dynamic doxycycline responsive nigrostriatal gdnf using a single raav vector
-
Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, et al. (2009). Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Mol Ther 17: 1857-1867
-
(2009)
Mol Ther
, vol.17
, pp. 1857-1867
-
-
Manfredsson, F.P.1
Burger, C.2
Rising, A.C.3
Zuobi-Hasona, K.4
Sullivan, L.F.5
Lewin, A.S.6
-
30
-
-
77952425513
-
Lack of humoral immune response to the tetracycline (tet) activator in rats injected intracranially with tet-off raav vectors
-
Han Y, Chang QA, Virag T, West NC, George D, Castro MG, et al. (2010). Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors. Gene Ther 17: 616-625
-
(2010)
Gene Ther
, vol.17
, pp. 616-625
-
-
Han, Y.1
Chang, Q.A.2
Virag, T.3
West, N.C.4
George, D.5
Castro, M.G.6
-
31
-
-
33747627183
-
Trends in herpes simplex virus type 1 and type 2 seroprevalence in the united states
-
Xu, F, Sternberg MR, Kottiri BJ, McQuillan GM, Lee FK, Nahmias AJ, et al. (2006). Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA 296: 964-973
-
(2006)
Jama
, vol.296
, pp. 964-973
-
-
Xu, F.1
Sternberg, M.R.2
Kottiri, B.J.3
McQuillan, G.M.4
Lee, F.K.5
Nahmias, A.J.6
-
32
-
-
84877017257
-
Pharmacokinetics of antibacterial agents in the CSF of children and adolescents
-
Sullins AK and Abdel-Rahman SM. (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatr Drugs 15: 93-117
-
(2013)
Paediatr Drugs
, vol.15
, pp. 93-117
-
-
Sullins, A.K.1
Abdel-Rahman, S.M.2
-
33
-
-
37249038595
-
A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types
-
Xie J, Nair A and Hermiston TW. (2008). A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types. Toxicol In Vitro 22: 261-266
-
(2008)
Toxicol in Vitro
, vol.22
, pp. 261-266
-
-
Xie, J.1
Nair, A.2
Hermiston, T.W.3
-
34
-
-
84887034083
-
Inducible control of gene expression with destabilized cre
-
Sando R 3rd, Baumgaertel K, Pieraut S, Torabi-Rander N, Wandless TJ, Mayford M, et al. (2013). Inducible control of gene expression with destabilized Cre. Nat Methods 10: 1085-1088
-
(2013)
Nat Methods
, vol.10
, pp. 1085-1088
-
-
Sando, R.1
Baumgaertel, K.2
Pieraut, S.3
Torabi-Rander, N.4
Wandless, T.J.5
Mayford, M.6
-
35
-
-
0025129116
-
Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson's disease
-
Mouradian MM, Heuser IJ, Baronti F and Chase TN. (1990). Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson's disease. Ann Neurol 27: 18-23
-
(1990)
Ann Neurol
, vol.27
, pp. 18-23
-
-
Mouradian, M.M.1
Heuser, I.J.2
Baronti, F.3
Chase, T.N.4
-
37
-
-
0033022953
-
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
-
Zolotukhin S, Byrne BJ, Mason E, Zolotukhin I, Potter M, Chesnut K, et al. (1999). Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 6: 973-985
-
(1999)
Gene Ther
, vol.6
, pp. 973-985
-
-
Zolotukhin, S.1
Byrne, B.J.2
Mason, E.3
Zolotukhin, I.4
Potter, M.5
Chesnut, K.6
-
38
-
-
84871997054
-
Universal real-time pcr for the detection and quantification of adenoassociated virus serotype 2-derived inverted terminal repeat sequences
-
Aurnhammer C, Haase M, Muether N, Hausl M, Rauschhuber C, Huber I, et al. (2012). Universal real-time PCR for the detection and quantification of adenoassociated virus serotype 2-derived inverted terminal repeat sequences. Hum Gene Ther Methods 23: 18-28
-
(2012)
Hum Gene Ther Methods
, vol.23
, pp. 18-28
-
-
Aurnhammer, C.1
Haase, M.2
Muether, N.3
Hausl, M.4
Rauschhuber, C.5
Huber, I.6
-
39
-
-
28144440866
-
The corridor task: A simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum
-
Dowd E, Monville C, Torres EM and Dunnett SB. (2005). The Corridor Task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum. Brain Res Bull 68: 24-30
-
(2005)
Brain Res Bull
, vol.68
, pp. 24-30
-
-
Dowd, E.1
Monville, C.2
Torres, E.M.3
Dunnett, S.B.4
-
40
-
-
0018421663
-
Excessive bracing reactions and their control by atropine and l-dopa in an animal analog of parkinsonism
-
Schallert T, De Ryck M, Whishaw IQ, Ramirez VD and Teitelbaum P. (1979). Excessive bracing reactions and their control by atropine and L-DOPA in an animal analog of Parkinsonism. Exp Neurol 64: 33-43
-
(1979)
Exp Neurol
, vol.64
, pp. 33-43
-
-
Schallert, T.1
De Ryck, M.2
Whishaw, I.Q.3
Ramirez, V.D.4
Teitelbaum, P.5
-
41
-
-
0029064091
-
Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
-
Olsson M, Nikkhah G, Bentlage C and Björklund A. (1995). Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15(5 Pt 2): 3863-3875
-
(1995)
J Neurosci
, vol.15
, Issue.5 PT2
, pp. 3863-3875
-
-
Olsson, M.1
Nikkhah, G.2
Bentlage, C.3
Björklund, A.4
-
42
-
-
84985280160
-
The efficiency of systematic sampling in stereology and its prediction
-
Gundersen HJ and Jensen EB. (1987). The efficiency of systematic sampling in stereology and its prediction. J Microsc 147(Pt 3): 229-263
-
(1987)
J Microsc
, vol.147
, Issue.PT3
, pp. 229-263
-
-
Gundersen, H.J.1
Jensen, E.B.2
-
43
-
-
0033083082
-
Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
-
West, MJ. (1999). Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci 22: 51-61
-
(1999)
Trends Neurosci
, vol.22
, pp. 51-61
-
-
West, M.J.1
|