A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types

Toxicology in Vitro

Volumn 22, Issue 1, 2008, Pages 261-266

  Xie, Jinger ^a   Nair, Ayyappan ^a   Hermiston, Terry W ^a  

^a Novel Technologies   (United States)

Author keywords

Cytotoxicity; Doxycycline; Ecdysone; Mifepristone

Indexed keywords

DOXYCYCLINE; ECDYSONE; LIGAND; MIFEPRISTONE; MURISTERONE A; PROGESTERONE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CULTURE; CELL DEATH; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN INDUCTION;

CELL DEATH; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; DRUG DELIVERY SYSTEMS; ECDYSTERONE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIGANDS; MIFEPRISTONE;

EID: 37249038595     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.08.019     Document Type: Article

References (40)

1. Amar L., Desclaux M., Faucon-Biguet N., Mallet J., and Vogel R. Control of small inhibitory RNA levels and RNA interference by doxycycline induced activation of a minimal RNA polymerase III promoter. Nucleic Acids Research 34 5 (2006) e37
2. Baptiste D.C., Hartwick A.T.E., Jollimore C.A.B., Baldridge W.H., Seigel G.M., and Kelly M.E.M. An investigation of the neuroprotective effects of tetracycline derivatives in experimental models of retinal cell death. Molecular Pharmacology 66 5 (2004) 1113-1122
3. Bettany J.T., and Wolowacz R.G. Tetracycline derivatives induce apoptosis selectively in cultured monocytes and macrophages but not in mesenchymal cells. Advances in Dental Research 12 (1998) 136-143
4. Bettany J.T., Peet N.M., Wolowacz R.G., Skerry T.M., and Grabowski P.S. Tetracyclines induce apoptosis in osteoclasts. Bone 27 1 (2000) 75-80
5. Cao T., He W., Roop D.R., and Wang X.J. K14-GLp65 transactivator induces transgene expression in embryonic epidermis. Genesis 32 (2002) 189-190
6. Clark Jr. J.M., and Chang A.Y. Inhibitors of the transfer of amino acids from aminoacyl soluble ribonucleic acid to proteins. Journal of Biological Chemistry 240 (1965) 4734-4739
7. Etrteby M.F.E., Liang Y., and Lewis R.W. Induction of apoptosis by mifepristone and tamoxifen in human LNCap prostate cancer cells in culture. The Prostate 43 (2000) 31-42
8. Fife R.S., Rougraff B.T., Proctor C., and Sledge Jr. G.W. Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells. The Journal of Laboratory and Clinical Medicine 130 5 (1997) 530-534
9. Fishel M.L., Smith M.L., He Y., and Kelley M.R. Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide. Clinical Cancer Research 13 1 (2007) 260-267
10. Gaddy V.T., Barrett J.T., Delk J.N., Kallab A.M., Porter A.G., and Schoenlein P.V. Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen- resistant breast cancer cells. Clinical Cancer Research 10 (2004) 5215-5225
11. Gallagher A.R., Schoenig K., Brown N., Bujard H., and Witzgall R. Use of the tetracycline system for inducible protein synthesis in the kidney. Journal of the American Society of Nephrology 14 (2003) 2042-2051
12. Gu Y., Lee H.M., Golub L.M., Sorsa T., Konttinen Y.T., and Simon S.R. Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines. Annals of Medicine 37 (2005) 450-460
13. Hosono T., Mizuguchi H., Katayama K., Xu Z., Sakurai F., Ishii-Watabe A., Kawabata K., Yamaguchi T., Nakagawa S., Mayumi T., and Hayakawa T. Adenovirus vector-mediated doxycycline-inducible RNA interference. Human Gene Therapy 15 (2004) 813-819
14. Innes F., Ramsbottom B., and White R.J. A test of the model that RNA polymerase lll transcription is regulated by selective induction of the 110 kDa subunit of TFlllC. Nucleic Acids Research 34 11 (2006) 3399-3407
15. Ito T., Hashimoto Y., Tanaka E., Kan, Takatsugu K., Tsunoda S., Sato F., Higashiyama M., Okumura T., and Shimada Y. An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo. Clinical Cancer Research 12 4 (2006) 1308-1316
16. Iwasaki H., Inoue H., Mitsuke Y., Badran A., Ikegaya S., and Ueda T. Doxycyxline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells. The Journal of Laboratory and Clinical Medicine 140 6 (2002) 382-386
17. Jaisser F. Inducible gene expression and gene modification in transgenic mice. Journal of the American Society of Nephrology 11 (2000) S95-S100
18. Kafri T., Praag H., Gage F.H., and Verma I.M. Lentiviral vectors: regulated gene expression. Molecular Therapy 1 6 (2000) 516-521
19. Klucher K.M., Lopez D.V., and Daley G.Q. Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression. Blood 91 10 (1998) 3927-3934
20. Liang Y., Eid M.A., Etreby F.E., Lewis R.W., and Kumar M.V. Mifepristone-induced secretion of transforming growth factor β1-induced apoptosis in prostate cancer cells. International Journal of Oncology 21 (2002) 1259-1267
21. Liu J., Kuszynski C.A., and Baxter B.T. Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes. Biochemical and Biophysical Research Communications 260 (1999) 562-567
22. Malich G., Markovic B., and Winder C. The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell lines. Toxicology 124 3 (1997) 179-192
23. Ngo V.N., Davis R.E., Lamy L., Yu X., Zhao H., Lenz G., Lam L.T., Dave S., Yang L., Powell J., and Staudt L.M. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 441 (2006) 106-110
24. No D., Yao T.-P., and Evans R.E. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 3346-3351
25. Oehme I., Boesser S., and Zoernig M. Agonists of an ecdysone- inducible mammalian expression system inhibit Fas Ligand- and TRAIL- induced apoptosis in the human colon carcinoma cell line RKO. Cell Death and Differentiation 13 (2006) 189-201
26. Onoda T., Ono T., Dhar D.K., Yamanoi A., and Nagasue N. Tetracycline analogues (doxycycline and COL-3) induce caspase- dependent and- independent apoptosis in human colon cancer cells. International Journal of Cancer 118 (2006) 1309-1315
27. O'Toole S.A., Sheppard B.L., Bonnar J.B., McGuinness E.P.J., Gleeson N.C., and Yoneda M. The MTS assay as an indicator of chemosensitivity/resistance in malignant gynaecological tumours. Cancer detection and prevention 27 1 (2003) 4778
28. Prange-Kiel J., Rume G.M., Wallwiener D., and Kiesel L. Inhibition of proliferation and differentiation by RU 486 in human endometrial stromal and epithelial cells in vitro. Experimental and Clinical Endocrinology and Diabetes 108 (2000) 275-281
29. Saez E., Nelson M.C., Eshelman B., Banayo E., Koder A., Cho G.J., and Evans R.M. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proceedings of the National Academy of Sciences of the United States of America 97 (2000) 14512-14517
30. Saikali Z., and Singh G. Doxycycline and other tetracyclines in the treatment of bone metastasis. Anticancer Drugs 14 (2003) 773-778
31. Sandler C., Nurmi K., Lindstedt K.A., Sorsa T., Golub L.M., Kovanen P.T., and Eklund K.K. Chemically modified tetracyclines induce apoptosis in cultured mast cells. International Immunopharmacology 5 (2005) 1611-1621
32. Sirin O., and Park F. Regulating gene expression using self-inactivating lentiviral vectors containing the mifepristone-inducible system. Gene 323 (2003) 67-77
33. Sourdeval M., Lemaire C., Brenner C., Boisvieux-Ulrich E., and Marano F. Mechanisms of doxycycline-induced cytotoxicity on human bronchial epithelial cells. Frontiers in Bioscience 11 (2006) 3036-3048
34. Tikka T., Usenius T., Tenhunen M., Keinanen R., and Koistinaho J. Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation. Journal of Neurochemistry 78 (2001) 1409-1414
35. Toniatti C., Bujard H., Cortese R., and Ciliberto G. Gene therapy progress and prospects: transcription regulatory systems. Gene Therapy 11 (2004) 649-657
36. Wang Y., DeMayo F.J., Tsai S.Y., and O'Malley B.W. Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotechnology 15 (1997) 239-243
37. Wetering M.v.d., Oving I., Muncan V., Fong M.T.P., Brantjes H., Leenen D.V., Holstege F.C.P., Brummelkamp T.R., Agami R., and Clevers H. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Reports 4 6 (2003) 609-615
38. Wu J., Liu T., Xie J., Xin F., and Guo L. Mitochondria and calpains mediate caspase-dependent apoptosis induced by doxycycline in hela cells. Cellular and Molecular Life Sciences 63 (2006) 949-957
39. Yamamoto A., Hen R., and Dauer W.T. The ons and offs of inducible transgenic technology: a review. Neurobiology of Disease 8 (2001) 923-932
40. Zhao B., Chua S.S., Burcin M.M., Reynolds S.D., Stripp B.R., Edwards R.A., Finegold M.J., Tsai S.Y., and DeMayo F.J. Phenotypic consequences of lung-specific inducible expression of FGF-3. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 5898-5903