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Volumn 21, Issue 5, 2015, Pages 285-294

Genetics and the placebo effect: The placebome

Author keywords

COMT; No treatment control; Pharmacogenomics; Placebo; RCT

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DOPAMINE; DOPAMINE BETA MONOOXYGENASE; MICRORNA; MU OPIATE RECEPTOR; PLACEBO; SEROTONIN UPTAKE INHIBITOR; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

EID: 84929048588     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.02.009     Document Type: Review
Times cited : (201)

References (100)
  • 1
    • 84872056489 scopus 로고    scopus 로고
    • Placebos in 19th century medicine: a quantitative analysis of the BMJ
    • Raicek J.E., et al. Placebos in 19th century medicine: a quantitative analysis of the BMJ. BMJ 2012, 345:e8326.
    • (2012) BMJ , vol.345 , pp. e8326
    • Raicek, J.E.1
  • 2
    • 0032159929 scopus 로고    scopus 로고
    • Intentional ignorance: a history of blind assessment and placebo controls in medicine
    • Kaptchuk T.J. Intentional ignorance: a history of blind assessment and placebo controls in medicine. Bull. Hist. Med. 1998, 72:389-433.
    • (1998) Bull. Hist. Med. , vol.72 , pp. 389-433
    • Kaptchuk, T.J.1
  • 3
    • 0032490288 scopus 로고    scopus 로고
    • Powerful placebo: the dark side of the randomised controlled trial
    • Kaptchuk T.J. Powerful placebo: the dark side of the randomised controlled trial. Lancet 1998, 351:1722-1725.
    • (1998) Lancet , vol.351 , pp. 1722-1725
    • Kaptchuk, T.J.1
  • 4
    • 84907985359 scopus 로고    scopus 로고
    • A meta-analysis of brain mechanisms of placebo analgesia: consistent findings and unanswered questions
    • Atlas L.Y., Wager T.D. A meta-analysis of brain mechanisms of placebo analgesia: consistent findings and unanswered questions. Handb. Exp. Pharmacol. 2014, 225:37-69.
    • (2014) Handb. Exp. Pharmacol. , vol.225 , pp. 37-69
    • Atlas, L.Y.1    Wager, T.D.2
  • 5
    • 84880933259 scopus 로고    scopus 로고
    • Placebo and the new physiology of the doctor-patient relationship
    • Benedetti F. Placebo and the new physiology of the doctor-patient relationship. Physiol. Rev. 2013, 93:1207-1246.
    • (2013) Physiol. Rev. , vol.93 , pp. 1207-1246
    • Benedetti, F.1
  • 7
    • 14044274119 scopus 로고    scopus 로고
    • Mechanisms of the placebo response and their impact on clinical trials and clinical practice
    • Finniss D.G., Benedetti F. Mechanisms of the placebo response and their impact on clinical trials and clinical practice. Pain 2005, 114:3-6.
    • (2005) Pain , vol.114 , pp. 3-6
    • Finniss, D.G.1    Benedetti, F.2
  • 8
    • 79960230129 scopus 로고    scopus 로고
    • Active albuterol or placebo, sham acupuncture, or no intervention in asthma
    • Wechsler M.E., et al. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N. Engl. J. Med. 2011, 365:119-126.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 119-126
    • Wechsler, M.E.1
  • 9
    • 84907225949 scopus 로고    scopus 로고
    • Outsmarting the placebo effect
    • Servick K. Outsmarting the placebo effect. Science 2014, 345:1446-1447.
    • (2014) Science , vol.345 , pp. 1446-1447
    • Servick, K.1
  • 10
    • 84913539693 scopus 로고    scopus 로고
    • Prediction of placebo responses: a systematic review of the literature
    • Horing B., et al. Prediction of placebo responses: a systematic review of the literature. Front. Psychol. 2014, 5:1079.
    • (2014) Front. Psychol. , vol.5 , pp. 1079
    • Horing, B.1
  • 11
    • 44149120469 scopus 로고    scopus 로고
    • Do 'placebo responders' exist?
    • Kaptchuk T.J., et al. Do 'placebo responders' exist?. Contemp. Clin. Trials 2008, 29:587-595.
    • (2008) Contemp. Clin. Trials , vol.29 , pp. 587-595
    • Kaptchuk, T.J.1
  • 12
    • 76749169724 scopus 로고    scopus 로고
    • Biological, clinical, and ethical advances of placebo effects
    • Finniss D.G., et al. Biological, clinical, and ethical advances of placebo effects. Lancet 2010, 375:686-695.
    • (2010) Lancet , vol.375 , pp. 686-695
    • Finniss, D.G.1
  • 13
    • 0018185529 scopus 로고
    • The narcotic antagonist naloxone enhances clinical pain
    • Levine J.D., et al. The narcotic antagonist naloxone enhances clinical pain. Nature 1978, 272:826-827.
    • (1978) Nature , vol.272 , pp. 826-827
    • Levine, J.D.1
  • 14
    • 0021723823 scopus 로고
    • Influence of the method of drug administration on analgesic response
    • Levine J.D., Gordon N.C. Influence of the method of drug administration on analgesic response. Nature 1984, 312:755-756.
    • (1984) Nature , vol.312 , pp. 755-756
    • Levine, J.D.1    Gordon, N.C.2
  • 15
    • 0019503181 scopus 로고
    • Analgesic responses to morphine and placebo in individuals with postoperative pain
    • Levine J.D., et al. Analgesic responses to morphine and placebo in individuals with postoperative pain. Pain 1981, 10:379-389.
    • (1981) Pain , vol.10 , pp. 379-389
    • Levine, J.D.1
  • 16
    • 30544433435 scopus 로고    scopus 로고
    • Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network
    • Bingel U., et al. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 2006, 120:8-15.
    • (2006) Pain , vol.120 , pp. 8-15
    • Bingel, U.1
  • 17
    • 23944464949 scopus 로고    scopus 로고
    • Placebo effects mediated by endogenous opioid activity on mu-opioid receptors
    • Zubieta J.K., et al. Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. J. Neurosci. 2005, 25:7754-7762.
    • (2005) J. Neurosci. , vol.25 , pp. 7754-7762
    • Zubieta, J.K.1
  • 18
    • 63449103043 scopus 로고    scopus 로고
    • Neurobiological mechanisms of placebo responses
    • Zubieta J.K., Stohler C.S. Neurobiological mechanisms of placebo responses. Ann. N. Y. Acad. Sci. 2009, 1156:198-210.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1156 , pp. 198-210
    • Zubieta, J.K.1    Stohler, C.S.2
  • 20
    • 0032938389 scopus 로고    scopus 로고
    • Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems
    • Amanzio M., Benedetti F. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J. Neurosci. 1999, 19:484-494.
    • (1999) J. Neurosci. , vol.19 , pp. 484-494
    • Amanzio, M.1    Benedetti, F.2
  • 21
    • 0030958301 scopus 로고    scopus 로고
    • Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide
    • Benedetti F., et al. Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain 1997, 71:135-140.
    • (1997) Pain , vol.71 , pp. 135-140
    • Benedetti, F.1
  • 22
    • 0029942941 scopus 로고    scopus 로고
    • The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia
    • Benedetti F. The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain 1996, 64:535-543.
    • (1996) Pain , vol.64 , pp. 535-543
    • Benedetti, F.1
  • 23
    • 0028827692 scopus 로고
    • Potentiation of placebo analgesia by proglumide
    • Benedetti F., et al. Potentiation of placebo analgesia by proglumide. Lancet 1995, 346:1231.
    • (1995) Lancet , vol.346 , pp. 1231
    • Benedetti, F.1
  • 24
    • 80053943575 scopus 로고    scopus 로고
    • Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
    • Benedetti F., et al. Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nat. Med. 2011, 17:1228-1230.
    • (2011) Nat. Med. , vol.17 , pp. 1228-1230
    • Benedetti, F.1
  • 25
    • 0032882313 scopus 로고    scopus 로고
    • An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
    • Price D.D., et al. An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 1999, 83:147-156.
    • (1999) Pain , vol.83 , pp. 147-156
    • Price, D.D.1
  • 26
    • 38949145711 scopus 로고    scopus 로고
    • Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses
    • Scott D.J., et al. Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch. Gen. Psychiatry 2008, 65:220-231.
    • (2008) Arch. Gen. Psychiatry , vol.65 , pp. 220-231
    • Scott, D.J.1
  • 27
    • 0035838997 scopus 로고    scopus 로고
    • Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease
    • de la Fuente-Fernandez R., et al. Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease. Science 2001, 293:1164-1166.
    • (2001) Science , vol.293 , pp. 1164-1166
    • de la Fuente-Fernandez, R.1
  • 28
    • 77955894068 scopus 로고    scopus 로고
    • Effects of expectation on placebo-induced dopamine release in Parkinson disease
    • Lidstone S.C., et al. Effects of expectation on placebo-induced dopamine release in Parkinson disease. Arch. Gen. Psychiatry 2010, 67:857-865.
    • (2010) Arch. Gen. Psychiatry , vol.67 , pp. 857-865
    • Lidstone, S.C.1
  • 29
    • 0036356299 scopus 로고    scopus 로고
    • Changes in brain function of depressed subjects during treatment with placebo
    • Leuchter A.F., et al. Changes in brain function of depressed subjects during treatment with placebo. Am. J. Psychiatry 2002, 159:122-129.
    • (2002) Am. J. Psychiatry , vol.159 , pp. 122-129
    • Leuchter, A.F.1
  • 30
    • 0036237860 scopus 로고    scopus 로고
    • The functional neuroanatomy of the placebo effect
    • Mayberg H.S., et al. The functional neuroanatomy of the placebo effect. Am. J. Psychiatry 2002, 159:728-737.
    • (2002) Am. J. Psychiatry , vol.159 , pp. 728-737
    • Mayberg, H.S.1
  • 31
    • 39849093340 scopus 로고    scopus 로고
    • Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration
    • Kirsch I., et al. Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med. 2008, 5:e45.
    • (2008) PLoS Med. , vol.5 , pp. e45
    • Kirsch, I.1
  • 32
    • 38349049478 scopus 로고    scopus 로고
    • Selective publication of antidepressant trials and its influence on apparent efficacy
    • Turner E.H., et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N. Engl. J. Med. 2008, 358:252-260.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 252-260
    • Turner, E.H.1
  • 33
    • 0030004521 scopus 로고    scopus 로고
    • Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
    • Lachman H.M., et al. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996, 6:243-250.
    • (1996) Pharmacogenetics , vol.6 , pp. 243-250
    • Lachman, H.M.1
  • 34
    • 79955548738 scopus 로고    scopus 로고
    • Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia
    • Bitsios P., Roussos P. Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia. Pharmacogenomics 2011, 12:559-566.
    • (2011) Pharmacogenomics , vol.12 , pp. 559-566
    • Bitsios, P.1    Roussos, P.2
  • 35
    • 84857572587 scopus 로고    scopus 로고
    • COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition
    • Farrell S.M., et al. COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biol. Psychiatry 2012, 71:538-544.
    • (2012) Biol. Psychiatry , vol.71 , pp. 538-544
    • Farrell, S.M.1
  • 36
    • 57349086379 scopus 로고    scopus 로고
    • Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism
    • Giakoumaki S.G., et al. Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism. Neuropsychopharmacology 2008, 33:3058-3068.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 3058-3068
    • Giakoumaki, S.G.1
  • 37
    • 84899706529 scopus 로고    scopus 로고
    • Genetic biomarkers of placebo response: what could it mean for future trial design?
    • Hall K.T., Kaptchuk T.J. Genetic biomarkers of placebo response: what could it mean for future trial design?. Clin. Invest. 2013, 3:311-314.
    • (2013) Clin. Invest. , vol.3 , pp. 311-314
    • Hall, K.T.1    Kaptchuk, T.J.2
  • 38
    • 84867862609 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome
    • Hall K.T., et al. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS ONE 2012, 7:e48135.
    • (2012) PLoS ONE , vol.7 , pp. e48135
    • Hall, K.T.1
  • 39
    • 84906934633 scopus 로고    scopus 로고
    • Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease
    • Hall K.T., et al. Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 2014, 34:2160-2167.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 2160-2167
    • Hall, K.T.1
  • 40
    • 84922632614 scopus 로고    scopus 로고
    • Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients
    • Hall K.T., et al. Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients. Brain Behav. 2015, 5:e00294.
    • (2015) Brain Behav. , vol.5 , pp. e00294
    • Hall, K.T.1
  • 41
    • 77953809083 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine
    • Hamidovic A., et al. Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine. Psychiatr. Genet. 2010, 20:85-92.
    • (2010) Psychiatr. Genet. , vol.20 , pp. 85-92
    • Hamidovic, A.1
  • 42
    • 77950678456 scopus 로고    scopus 로고
    • Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study
    • Tchivileva I.E., et al. Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet. Genomics 2010, 20:239-248.
    • (2010) Pharmacogenet. Genomics , vol.20 , pp. 239-248
    • Tchivileva, I.E.1
  • 43
    • 84875691194 scopus 로고    scopus 로고
    • Analysis of 34 candidate genes in bupropion and placebo remission
    • Tiwari A.K., et al. Analysis of 34 candidate genes in bupropion and placebo remission. Int. J. Neuropsychopharmacol. 2013, 16:771-781.
    • (2013) Int. J. Neuropsychopharmacol. , vol.16 , pp. 771-781
    • Tiwari, A.K.1
  • 44
    • 7444232703 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    • Weickert T.W., et al. Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications. Biol. Psychiatry 2004, 56:677-682.
    • (2004) Biol. Psychiatry , vol.56 , pp. 677-682
    • Weickert, T.W.1
  • 45
    • 17844368319 scopus 로고    scopus 로고
    • Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
    • Meyer-Lindenberg A., et al. Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat. Neurosci. 2005, 8:594-596.
    • (2005) Nat. Neurosci. , vol.8 , pp. 594-596
    • Meyer-Lindenberg, A.1
  • 46
    • 34548813860 scopus 로고    scopus 로고
    • Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
    • Yavich L., et al. Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. J. Neurosci. 2007, 27:10196-10209.
    • (2007) J. Neurosci. , vol.27 , pp. 10196-10209
    • Yavich, L.1
  • 47
    • 0035173378 scopus 로고    scopus 로고
    • DbSNP: the NCBI database of genetic variation
    • Sherry S.T., et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 2001, 29:308-311.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 308-311
    • Sherry, S.T.1
  • 48
    • 0028264457 scopus 로고
    • Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans
    • McLeod H.L., et al. Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans. J. Pharmacol. Exp. Ther. 1994, 270:26-29.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 26-29
    • McLeod, H.L.1
  • 49
    • 0032777995 scopus 로고    scopus 로고
    • Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles
    • Palmatier M.A., et al. Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol. Psychiatry 1999, 46:557-567.
    • (1999) Biol. Psychiatry , vol.46 , pp. 557-567
    • Palmatier, M.A.1
  • 50
    • 43249121870 scopus 로고    scopus 로고
    • Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
    • Kaptchuk T.J., et al. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ 2008, 336:999-1003.
    • (2008) BMJ , vol.336 , pp. 999-1003
    • Kaptchuk, T.J.1
  • 51
    • 84904472318 scopus 로고    scopus 로고
    • Placebo analgesia and reward processing: integrating genetics, personality, and intrinsic brain activity
    • Yu R., et al. Placebo analgesia and reward processing: integrating genetics, personality, and intrinsic brain activity. Hum. Brain Mapp. 2014, 35:4583-4593.
    • (2014) Hum. Brain Mapp. , vol.35 , pp. 4583-4593
    • Yu, R.1
  • 52
    • 84907145066 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses
    • Wendt L., et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. PLoS ONE 2014, 9:e107665.
    • (2014) PLoS ONE , vol.9 , pp. e107665
    • Wendt, L.1
  • 53
    • 56149100442 scopus 로고    scopus 로고
    • Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo
    • Mickey B.J., et al. Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo. J. Neurosci. 2008, 28:11354-11359.
    • (2008) J. Neurosci. , vol.28 , pp. 11354-11359
    • Mickey, B.J.1
  • 54
    • 0026343878 scopus 로고
    • Human monoamine oxidase A gene determines levels of enzyme activity
    • Hotamisligil G.S., Breakefield X.O. Human monoamine oxidase A gene determines levels of enzyme activity. Am. J. Hum. Genet. 1991, 49:383-392.
    • (1991) Am. J. Hum. Genet. , vol.49 , pp. 383-392
    • Hotamisligil, G.S.1    Breakefield, X.O.2
  • 55
    • 68449085750 scopus 로고    scopus 로고
    • Monoamine oxidase a and catechol-O-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    • Leuchter A.F., et al. Monoamine oxidase a and catechol-O-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. J. Clin. Psychopharmacol. 2009, 29:372-377.
    • (2009) J. Clin. Psychopharmacol. , vol.29 , pp. 372-377
    • Leuchter, A.F.1
  • 56
    • 0034353647 scopus 로고    scopus 로고
    • Dopamine D3 receptors expressed by all mesencephalic dopamine neurons
    • Diaz J., et al. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. J. Neurosci. 2000, 20:8677-8684.
    • (2000) J. Neurosci. , vol.20 , pp. 8677-8684
    • Diaz, J.1
  • 57
    • 0025918637 scopus 로고
    • Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA
    • Bouthenet M.L., et al. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA. Brain Res. 1991, 564:203-219.
    • (1991) Brain Res. , vol.564 , pp. 203-219
    • Bouthenet, M.L.1
  • 58
    • 0031595788 scopus 로고    scopus 로고
    • Mapping of dopamine D3 receptor binding site by pharmacological characterization of mutants expressed in CHO cells with the Semliki Forest virus system
    • Lundstrom K., et al. Mapping of dopamine D3 receptor binding site by pharmacological characterization of mutants expressed in CHO cells with the Semliki Forest virus system. J. Recept. Signal Transduct. Res. 1998, 18:133-150.
    • (1998) J. Recept. Signal Transduct. Res. , vol.18 , pp. 133-150
    • Lundstrom, K.1
  • 59
    • 84878647076 scopus 로고    scopus 로고
    • Association of dopamine-related genetic loci to dopamine D3 receptor antagonist ABT-925 clinical response
    • Bhathena A., et al. Association of dopamine-related genetic loci to dopamine D3 receptor antagonist ABT-925 clinical response. Transl. Psychiatry 2013, 3:e245.
    • (2013) Transl. Psychiatry , vol.3 , pp. e245
    • Bhathena, A.1
  • 60
    • 84898842319 scopus 로고    scopus 로고
    • Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans
    • Arias A.J., et al. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans. Am. J. Addict. 2014, 23:288-293.
    • (2014) Am. J. Addict. , vol.23 , pp. 288-293
    • Arias, A.J.1
  • 61
    • 0026482150 scopus 로고
    • Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo
    • Altar C.A., et al. Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:11347-11351.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 11347-11351
    • Altar, C.A.1
  • 62
    • 0037150793 scopus 로고    scopus 로고
    • Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro
    • Goggi J., et al. Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain Res. 2002, 941:34-42.
    • (2002) Brain Res. , vol.941 , pp. 34-42
    • Goggi, J.1
  • 63
    • 79960043825 scopus 로고    scopus 로고
    • Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats
    • Miczek K.A., et al. Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats. J. Neurosci. 2011, 31:9848-9857.
    • (2011) J. Neurosci. , vol.31 , pp. 9848-9857
    • Miczek, K.A.1
  • 64
    • 35348832393 scopus 로고    scopus 로고
    • Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    • Krishnan V., et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 2007, 131:391-404.
    • (2007) Cell , vol.131 , pp. 391-404
    • Krishnan, V.1
  • 65
    • 49749091153 scopus 로고    scopus 로고
    • Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study
    • Vaccarino V., et al. Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biol. Psychiatry 2008, 64:476-483.
    • (2008) Biol. Psychiatry , vol.64 , pp. 476-483
    • Vaccarino, V.1
  • 66
    • 84899478067 scopus 로고    scopus 로고
    • Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans
    • Pecina M., et al. Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans. J. Neurosci. 2014, 34:5874-5881.
    • (2014) J. Neurosci. , vol.34 , pp. 5874-5881
    • Pecina, M.1
  • 67
    • 25444491710 scopus 로고    scopus 로고
    • Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    • Zhang Y., et al. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J. Biol. Chem. 2005, 280:32618-32624.
    • (2005) J. Biol. Chem. , vol.280 , pp. 32618-32624
    • Zhang, Y.1
  • 68
    • 34548653719 scopus 로고    scopus 로고
    • The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
    • Kroslak T., et al. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J. Neurochem. 2007, 103:77-87.
    • (2007) J. Neurochem. , vol.103 , pp. 77-87
    • Kroslak, T.1
  • 69
    • 84925532737 scopus 로고    scopus 로고
    • Effects of the mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures
    • Pecina M., et al. Effects of the mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures. Neuropsychopharmacology 2015, 40:957-965.
    • (2015) Neuropsychopharmacology , vol.40 , pp. 957-965
    • Pecina, M.1
  • 70
    • 84913594736 scopus 로고    scopus 로고
    • Variation in mu-opioid receptor gene as a moderator of naltrexone treatment to reduce heavy drinking in a high functioning cohort
    • Chen A.C., et al. Variation in mu-opioid receptor gene as a moderator of naltrexone treatment to reduce heavy drinking in a high functioning cohort. J. Alcohol. Drug Depend. 2013, 1:101.
    • (2013) J. Alcohol. Drug Depend. , vol.1 , pp. 101
    • Chen, A.C.1
  • 71
    • 0037207078 scopus 로고    scopus 로고
    • Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives
    • Hohmann A.G. Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives. Chem. Phys. Lipids 2002, 121:173-190.
    • (2002) Chem. Phys. Lipids , vol.121 , pp. 173-190
    • Hohmann, A.G.1
  • 72
    • 41749094029 scopus 로고    scopus 로고
    • The role of learning in nocebo and placebo effects
    • Colloca L., et al. The role of learning in nocebo and placebo effects. Pain 2008, 136:211-218.
    • (2008) Pain , vol.136 , pp. 211-218
    • Colloca, L.1
  • 73
    • 84894559946 scopus 로고    scopus 로고
    • FAAH selectively influences placebo effects
    • Pecina M., et al. FAAH selectively influences placebo effects. Mol. Psychiatry 2014, 19:385-391.
    • (2014) Mol. Psychiatry , vol.19 , pp. 385-391
    • Pecina, M.1
  • 74
    • 84880135878 scopus 로고    scopus 로고
    • A genome-wide association study of a sustained pattern of antidepressant response
    • Hunter A.M., et al. A genome-wide association study of a sustained pattern of antidepressant response. J. Psychiatr. Res. 2013, 47:1157-1165.
    • (2013) J. Psychiatr. Res. , vol.47 , pp. 1157-1165
    • Hunter, A.M.1
  • 75
    • 58149390186 scopus 로고    scopus 로고
    • A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety
    • Furmark T., et al. A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety. J. Neurosci. 2008, 28:13066-13074.
    • (2008) J. Neurosci. , vol.28 , pp. 13066-13074
    • Furmark, T.1
  • 76
    • 20044379425 scopus 로고    scopus 로고
    • The placebo effect in irritable bowel syndrome trials: a meta-analysis
    • Patel S.M., et al. The placebo effect in irritable bowel syndrome trials: a meta-analysis. Neurogastroenterol. Motil. 2005, 17:332-340.
    • (2005) Neurogastroenterol. Motil. , vol.17 , pp. 332-340
    • Patel, S.M.1
  • 77
    • 53049101630 scopus 로고    scopus 로고
    • The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications
    • Bialecka M., et al. The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. Pharmacogenet. Genomics 2008, 18:815-821.
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 815-821
    • Bialecka, M.1
  • 78
    • 84919385896 scopus 로고    scopus 로고
    • Specific and common genes implicated across major mental disorders: a review of meta-analysis studies
    • Gatt J.M., et al. Specific and common genes implicated across major mental disorders: a review of meta-analysis studies. J. Psychiatr. Res. 2015, 60C:1-13.
    • (2015) J. Psychiatr. Res. , vol.60 C , pp. 1-13
    • Gatt, J.M.1
  • 79
    • 42949179424 scopus 로고    scopus 로고
    • Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men
    • Annerbrink K., et al. Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. Metabolism 2008, 57:708-711.
    • (2008) Metabolism , vol.57 , pp. 708-711
    • Annerbrink, K.1
  • 80
    • 45749098246 scopus 로고    scopus 로고
    • Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
    • Kanasaki K., et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 2008, 453:1117-1121.
    • (2008) Nature , vol.453 , pp. 1117-1121
    • Kanasaki, K.1
  • 81
    • 77950424992 scopus 로고    scopus 로고
    • Platelet-mediated metabolism of the common dietary flavonoid, quercetin
    • Wright B., et al. Platelet-mediated metabolism of the common dietary flavonoid, quercetin. PLoS ONE 2010, 5:e9673.
    • (2010) PLoS ONE , vol.5 , pp. e9673
    • Wright, B.1
  • 82
    • 0015351514 scopus 로고
    • Comparative inhibitory effects of vitamins on methylating enzymes
    • Thithapandha A., Srinoot P. Comparative inhibitory effects of vitamins on methylating enzymes. Comp. Gen. Pharmacol. 1972, 3:139-144.
    • (1972) Comp. Gen. Pharmacol. , vol.3 , pp. 139-144
    • Thithapandha, A.1    Srinoot, P.2
  • 83
    • 84871323237 scopus 로고    scopus 로고
    • Developing new drug treatments in the era of network medicine
    • Silverman E.K., Loscalzo J. Developing new drug treatments in the era of network medicine. Clin. Pharmacol. Ther. 2013, 93:26-28.
    • (2013) Clin. Pharmacol. Ther. , vol.93 , pp. 26-28
    • Silverman, E.K.1    Loscalzo, J.2
  • 84
    • 84862529965 scopus 로고    scopus 로고
    • Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine
    • Antman E.S., et al. Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine. Wiley Interdiscip. Rev. Syst. Biol. Med. 2012, 4:367-383.
    • (2012) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.4 , pp. 367-383
    • Antman, E.S.1
  • 85
    • 84923306828 scopus 로고    scopus 로고
    • Uncovering disease-disease relationships through the incomplete interactome
    • Menche J., et al. Uncovering disease-disease relationships through the incomplete interactome. Science 2015, 347:1257601.
    • (2015) Science , vol.347 , pp. 1257601
    • Menche, J.1
  • 86
    • 79952674000 scopus 로고    scopus 로고
    • Interactome networks and human disease
    • Vidal M., et al. Interactome networks and human disease. Cell 2011, 144:986-998.
    • (2011) Cell , vol.144 , pp. 986-998
    • Vidal, M.1
  • 87
    • 61349086157 scopus 로고    scopus 로고
    • Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain
    • Rakvag T.T., et al. Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Mol. Pain 2008, 4:64.
    • (2008) Mol. Pain , vol.4 , pp. 64
    • Rakvag, T.T.1
  • 88
    • 20444451123 scopus 로고    scopus 로고
    • The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients
    • Rakvag T.T., et al. The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain 2005, 116:73-78.
    • (2005) Pain , vol.116 , pp. 73-78
    • Rakvag, T.T.1
  • 89
    • 78650988467 scopus 로고    scopus 로고
    • Placebos without deception: a randomized controlled trial in irritable bowel syndrome
    • Kaptchuk T.J., et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS ONE 2010, 5:e15591.
    • (2010) PLoS ONE , vol.5 , pp. e15591
    • Kaptchuk, T.J.1
  • 90
    • 84892514261 scopus 로고    scopus 로고
    • Altered placebo and drug labeling changes the outcome of episodic migraine attacks
    • 218ra5.
    • Kam-Hansen S., et al. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci. Transl. Med. 2014, 6:218ra5.
    • (2014) Sci. Transl. Med. , vol.6
    • Kam-Hansen, S.1
  • 91
    • 84864407465 scopus 로고    scopus 로고
    • Open-label placebo for major depressive disorder: a pilot randomized controlled trial
    • Kelley J.M., et al. Open-label placebo for major depressive disorder: a pilot randomized controlled trial. Psychother. Psychosom. 2012, 81:312-314.
    • (2012) Psychother. Psychosom. , vol.81 , pp. 312-314
    • Kelley, J.M.1
  • 92
    • 84885127320 scopus 로고    scopus 로고
    • Ethical, legal, and social implications of incorporating genomic information into electronic health records
    • Hazin R., et al. Ethical, legal, and social implications of incorporating genomic information into electronic health records. Genet. Med. 2013, 15:810-816.
    • (2013) Genet. Med. , vol.15 , pp. 810-816
    • Hazin, R.1
  • 93
    • 84907424907 scopus 로고    scopus 로고
    • Personalized medicine and ethics
    • Josko D. Personalized medicine and ethics. Clin. Lab. Sci. 2014, 27:185-190.
    • (2014) Clin. Lab. Sci. , vol.27 , pp. 185-190
    • Josko, D.1
  • 94
    • 84875932002 scopus 로고    scopus 로고
    • New approaches to molecular diagnosis
    • Korf B.R., Rehm H.L. New approaches to molecular diagnosis. JAMA 2013, 309:1511-1521.
    • (2013) JAMA , vol.309 , pp. 1511-1521
    • Korf, B.R.1    Rehm, H.L.2
  • 95
    • 84899481029 scopus 로고    scopus 로고
    • Translating personalized medicine using new genetic technologies in clinical practice: the ethical issues
    • Ormond K.E., Cho M.K. Translating personalized medicine using new genetic technologies in clinical practice: the ethical issues. Per. Med. 2014, 11:211-222.
    • (2014) Per. Med. , vol.11 , pp. 211-222
    • Ormond, K.E.1    Cho, M.K.2
  • 96
    • 84892547340 scopus 로고    scopus 로고
    • Essential elements of personalized medicine
    • Burke W., et al. Essential elements of personalized medicine. Urol. Oncol. 2014, 32:193-197.
    • (2014) Urol. Oncol. , vol.32 , pp. 193-197
    • Burke, W.1
  • 97
    • 33645062724 scopus 로고    scopus 로고
    • Methodological issues in clinical trials of opioids for chronic pain
    • Katz N. Methodological issues in clinical trials of opioids for chronic pain. Neurology 2005, 65(Suppl. 4):S32-S49.
    • (2005) Neurology , vol.65 , pp. S32-S49
    • Katz, N.1
  • 98
    • 1542290332 scopus 로고    scopus 로고
    • Does elimination of placebo responders in a placebo run-in increase the treatment effect in randomized clinical trials? A meta-analytic evaluation
    • Lee S., et al. Does elimination of placebo responders in a placebo run-in increase the treatment effect in randomized clinical trials? A meta-analytic evaluation. Depress. Anxiety 2004, 19:10-19.
    • (2004) Depress. Anxiety , vol.19 , pp. 10-19
    • Lee, S.1
  • 99
    • 44649161550 scopus 로고    scopus 로고
    • Enriched enrollment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review
    • Straube S., et al. Enriched enrollment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review. Br. J. Clin. Pharmacol. 2008, 66:266-275.
    • (2008) Br. J. Clin. Pharmacol. , vol.66 , pp. 266-275
    • Straube, S.1
  • 100
    • 0036884030 scopus 로고    scopus 로고
    • Evaluating how placebos produce change. Logical and causal traps and understanding cognitive explanatory mechanisms
    • Caspi O., Bootzin R.R. Evaluating how placebos produce change. Logical and causal traps and understanding cognitive explanatory mechanisms. Eval. Health Prof. 2002, 25:436-464.
    • (2002) Eval. Health Prof. , vol.25 , pp. 436-464
    • Caspi, O.1    Bootzin, R.R.2


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