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Volumn 17, Issue 3, 2005, Pages 332-340

The placebo effect in irritable bowel syndrome trials: A meta-analysis

Author keywords

Irritable bowel syndrome; Meta analysis; Placebo

Indexed keywords

ACTIVATED CARBON; ALVERINE CITRATE; AMITRIPTYLINE; CHLORDIAZEPOXIDE; CISAPRIDE; CLONIDINE; DESIPRAMINE; DIAZEPAM; DICYCLOVERINE; DOMPERIDONE; ISPAGULA; LEUPRORELIN; LIDAMIDINE; LOPERAMIDE; LOXIGLUMIDE; NALOXONE; OCTATROPINE METHYLBROMIDE; OTILONIUM BROMIDE; PEPPERMINT OIL; PHENYTOIN; PIRENZEPINE; PLACEBO; ROCIVERINE; TEGASEROD; TIMOLOL; TRIMEBUTINE; TRIMIPRAMINE;

EID: 20044379425     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2005.00650.x     Document Type: Conference Paper
Times cited : (274)

References (78)
  • 4
    • 2142755325 scopus 로고    scopus 로고
    • A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's disease
    • Su C, Lichtenstein GR, Krok K, Brensinger CM, Lewis JD. A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's disease. Gastroenterology 2004; 126: 1257-69.
    • (2004) Gastroenterology , vol.126 , pp. 1257-1269
    • Su, C.1    Lichtenstein, G.R.2    Krok, K.3    Brensinger, C.M.4    Lewis, J.D.5
  • 5
    • 0032716774 scopus 로고    scopus 로고
    • Problems and challenges in the design of irritable bowel syndrome clinical trials: Experience from published trials
    • Spiller RC. Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials. Am J Med 1999; 107: 91S-7S.
    • (1999) Am J Med , vol.107
    • Spiller, R.C.1
  • 6
    • 0034682643 scopus 로고    scopus 로고
    • Pharmacologic treatment of the irritable bowel syndrome: A systematic review of randomized, controlled trials
    • Jailwala J, Imperiale TF, Kroenke K. Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Ann Intern Med 2000; 133: 136-47.
    • (2000) Ann Intern Med , vol.133 , pp. 136-147
    • Jailwala, J.1    Imperiale, T.F.2    Kroenke, K.3
  • 7
    • 0023920461 scopus 로고
    • Controlled treatment trials in the irritable bowel syndrome: A critique
    • Klein KB. Controlled treatment trials in the irritable bowel syndrome: a critique. Gastroenterology 1988; 95: 232-41.
    • (1988) Gastroenterology , vol.95 , pp. 232-241
    • Klein, K.B.1
  • 8
    • 0033915005 scopus 로고    scopus 로고
    • Placebos: A review of the placebo response
    • Thompson WG. Placebos: a review of the placebo response. Am J Gastroenterol 2000; 95: 1637-43.
    • (2000) Am J Gastroenterol , vol.95 , pp. 1637-1643
    • Thompson, W.G.1
  • 9
    • 0028545157 scopus 로고
    • Placebo and placebo effect: Their impact on the evaluation of drug response in patients
    • Dobrilla G, Scarpignato C. Placebo and placebo effect: their impact on the evaluation of drug response in patients. Dig Dis 1994; 12: 368-77.
    • (1994) Dig Dis , vol.12 , pp. 368-377
    • Dobrilla, G.1    Scarpignato, C.2
  • 10
    • 2342453772 scopus 로고    scopus 로고
    • Pathophysiology as a basis for understanding symptom complexes and therapeutic targets
    • Camilleri M, Talley NJ. Pathophysiology as a basis for understanding symptom complexes and therapeutic targets. Neurogastroenterol Motil 2004; 16: 135-42.
    • (2004) Neurogastroenterol Motil , vol.16 , pp. 135-142
    • Camilleri, M.1    Talley, N.J.2
  • 11
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad AR, Moore RA, Carroll D et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 12
    • 0028310313 scopus 로고
    • Effect of leuprolide acetate in patients with moderate to severe functional bowel disease. Double-blind, placebo-controlled study
    • Mathias JR, Clench MH, Reeves-Darby VG et al. Effect of leuprolide acetate in patients with moderate to severe functional bowel disease. Double-blind, placebo-controlled study. Dig Dis Sci 1994; 39: 1155-62.
    • (1994) Dig Dis Sci , vol.39 , pp. 1155-1162
    • Mathias, J.R.1    Clench, M.H.2    Reeves-Darby, V.G.3
  • 15
    • 0033619529 scopus 로고    scopus 로고
    • Explaining heterogeneity in meta-analysis: A comparison of methods
    • Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 1999; 18: 2693-708.
    • (1999) Stat Med , vol.18 , pp. 2693-2708
    • Thompson, S.G.1    Sharp, S.J.2
  • 16
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 17
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-34.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 18
    • 20044376862 scopus 로고    scopus 로고
    • Stata v. StataCorp. Copyright 1984-2003. College Station, Texas, USA: Stata v. StataCorp.
    • Stata v. StataCorp. Copyright 1984-2003. College Station, Texas, USA: Stata v. StataCorp.
  • 19
    • 0031722682 scopus 로고    scopus 로고
    • Symptom relief with amitriptyline in the irritable bowel syndrome
    • Rajagopalan M, Kurian G, John J. Symptom relief with amitriptyline in the irritable bowel syndrome. J Gastroenterol Hepatol 1998; 13: 738-41.
    • (1998) J Gastroenterol Hepatol , vol.13 , pp. 738-741
    • Rajagopalan, M.1    Kurian, G.2    John, J.3
  • 20
    • 0037051872 scopus 로고    scopus 로고
    • Placebo response in studies of major depression: Variable, substantial, and growing
    • Walsh BT, Seidman SN, Sysko R, Gould M. Placebo response in studies of major depression: variable, substantial, and growing. JAMA 2002; 287: 1840-7.
    • (2002) JAMA , vol.287 , pp. 1840-1847
    • Walsh, B.T.1    Seidman, S.N.2    Sysko, R.3    Gould, M.4
  • 21
    • 0028242319 scopus 로고
    • The importance of placebo effects in pain treatment and research
    • Turner JA, Deyo RA, Loeser JD, Von Korff M, Fordyce WE. The importance of placebo effects in pain treatment and research. JAMA 1994; 271: 1609-14.
    • (1994) JAMA , vol.271 , pp. 1609-1614
    • Turner, J.A.1    Deyo, R.A.2    Loeser, J.D.3    Von Korff, M.4    Fordyce, W.E.5
  • 22
    • 0029937769 scopus 로고    scopus 로고
    • Variation in the placebo effect in randomised controlled trials of analgesics: All is as blind as it seems
    • McQuay H, Carroll D, Moore A. Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems. Pain 1996; 64: 331-5.
    • (1996) Pain , vol.64 , pp. 331-335
    • McQuay, H.1    Carroll, D.2    Moore, A.3
  • 23
    • 0036301888 scopus 로고    scopus 로고
    • The placebo effect and randomized trials: Analysis of conventional medicine
    • Moyad MA. The placebo effect and randomized trials: analysis of conventional medicine. Urol Clin North Am 2002; 29: 125-33, ix-x.
    • (2002) Urol Clin North Am , vol.29 , pp. 125-133
    • Moyad, M.A.1
  • 25
    • 0033789462 scopus 로고    scopus 로고
    • A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome
    • Saito YA, Locke GR, Talley NJ, Zinsmeister AR, Fett SL, Melton LJ III. A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome. Am J Gastroenterol 2000; 95: 2816-24.
    • (2000) Am J Gastroenterol , vol.95 , pp. 2816-2824
    • Saito, Y.A.1    Locke, G.R.2    Talley, N.J.3    Zinsmeister, A.R.4    Fett, S.L.5    Melton III, L.J.6
  • 26
    • 0037266035 scopus 로고    scopus 로고
    • The problem of the placebo response in clinical trials for psychiatric disorders: Culprits, possible remedies, and a novel study design approach
    • Fava M, Evins AE, Dorer DJ, Schoenfeld DA. The problem of the placebo response in clinical trials for psychiatric disorders: culprits, possible remedies, and a novel study design approach. Psychother Psychosom 2003; 72: 115-27.
    • (2003) Psychother Psychosom , vol.72 , pp. 115-127
    • Fava, M.1    Evins, A.E.2    Dorer, D.J.3    Schoenfeld, D.A.4
  • 27
    • 0034043795 scopus 로고    scopus 로고
    • Justified deception? The single blind placebo in drug research
    • Evans M. Justified deception? The single blind placebo in drug research. J Med Ethics 2000; 26: 188-93.
    • (2000) J Med Ethics , vol.26 , pp. 188-193
    • Evans, M.1
  • 29
    • 0032054226 scopus 로고    scopus 로고
    • Threats to the validity of clinical trials employing enrichment strategies for sample selection
    • Leber PD, Davis CS. Threats to the validity of clinical trials employing enrichment strategies for sample selection. Control Clin Trials 1998; 19: 178-87.
    • (1998) Control Clin Trials , vol.19 , pp. 178-187
    • Leber, P.D.1    Davis, C.S.2
  • 30
    • 0342902205 scopus 로고    scopus 로고
    • Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment
    • Hrobjartsson A, Gotzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001; 344(Suppl. 2): 1594-602.
    • (2001) N Engl J Med , vol.344 , Issue.SUPPL. 2 , pp. 1594-1602
    • Hrobjartsson, A.1    Gotzsche, P.C.2
  • 32
    • 0346101528 scopus 로고    scopus 로고
    • Choosing outcome variables: Global assessment and diaries
    • Naliboff BD. Choosing outcome variables: global assessment and diaries. Gastroenterology 2004; 126: S129-34.
    • (2004) Gastroenterology , vol.126
    • Naliboff, B.D.1
  • 33
    • 18744388283 scopus 로고    scopus 로고
    • Systematic review on the management of irritable bowel syndrome in North America
    • Brandt LJ, Bjorkman D, Fennerty MB et al. Systematic review on the management of irritable bowel syndrome in North America. Am J Gastroenterol 2002; 97: S7-26.
    • (2002) Am J Gastroenterol , vol.97
    • Brandt, L.J.1    Bjorkman, D.2    Fennerty, M.B.3
  • 36
    • 84921002325 scopus 로고
    • A double-blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome
    • Soltoft J, Krag B, Gudmand-Hoyer E, Kristensen E, Wulff HR. A double-blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome. Lancet 1976; 7: 270-2.
    • (1976) Lancet , vol.7 , pp. 270-272
    • Soltoft, J.1    Krag, B.2    Gudmand-Hoyer, E.3    Kristensen, E.4    Wulff, H.R.5
  • 37
    • 0019156581 scopus 로고
    • Use of the peripheral dopamine antagonist, domperidone, in the management of gastro-intestinal symptoms in patients with irritable bowel syndrome
    • Milo R. Use of the peripheral dopamine antagonist, domperidone, in the management of gastro-intestinal symptoms in patients with irritable bowel syndrome. Curr Med Res Opin 1980; 6: 577-84.
    • (1980) Curr Med Res Opin , vol.6 , pp. 577-584
    • Milo, R.1
  • 38
    • 0019135104 scopus 로고
    • Double blind trial of trimebutine in the irritable bowel syndrome
    • Fielding JF. Double blind trial of trimebutine in the irritable bowel syndrome. Ir Med J 1980; 73: 377-9.
    • (1980) Ir Med J , vol.73 , pp. 377-379
    • Fielding, J.F.1
  • 40
    • 0019450179 scopus 로고
    • Timolol treatment in the irritable bowel syndrome
    • Fielding JF. Timolol treatment in the irritable bowel syndrome. Digestion 1981; 22: 155-8.
    • (1981) Digestion , vol.22 , pp. 155-158
    • Fielding, J.F.1
  • 41
    • 0019460393 scopus 로고
    • Treatment of the irritable bowel syndrome with bentyl (dicyclomine hydrochloride)
    • Page JG, Dirnberger GM. Treatment of the irritable bowel syndrome with bentyl (dicyclomine hydrochloride). J Clin Gastroenterol 1981; 3: 153-6.
    • (1981) J Clin Gastroenterol , vol.3 , pp. 153-156
    • Page, J.G.1    Dirnberger, G.M.2
  • 42
    • 0019825648 scopus 로고
    • Clinical evaluation of octatropine methyl-bromide plus diazepam (Valpinax) in the treatment of the irritable bowel syndrome
    • Guslandi M, Evangelista A, Testoni PA, Tittobello A. Clinical evaluation of octatropine methyl-bromide plus diazepam (Valpinax) in the treatment of the irritable bowel syndrome. Clin Trials J 1981; 18: 138-44.
    • (1981) Clin Trials J , vol.18 , pp. 138-144
    • Guslandi, M.1    Evangelista, A.2    Testoni, P.A.3    Tittobello, A.4
  • 43
    • 0020049140 scopus 로고
    • Domperidone treatment in the irritable bowel syndrome
    • Fielding JF. Domperidone treatment in the irritable bowel syndrome. Digestion 1982; 23: 125-7.
    • (1982) Digestion , vol.23 , pp. 125-127
    • Fielding, J.F.1
  • 44
    • 0020142495 scopus 로고
    • Role of ispaghula husk in the management of irritable bowel syndrome (a randomized double-blind crossover study)
    • Golechha AC, Chadda VS, Chadda S, Sharma SK, Mishra SN. Role of ispaghula husk in the management of irritable bowel syndrome (a randomized double-blind crossover study). J Assoc Physicians India 1982; 30: 353-5.
    • (1982) J Assoc Physicians India , vol.30 , pp. 353-355
    • Golechha, A.C.1    Chadda, V.S.2    Chadda, S.3    Sharma, S.K.4    Mishra, S.N.5
  • 45
    • 0019950651 scopus 로고
    • The effect of trimipramine in patients with the irritable bowel syndrome. A double-blind study
    • Myren J, Groth H, Larssen SE, Larsen S. The effect of trimipramine in patients with the irritable bowel syndrome. A double-blind study. Scand J Gastroenterol 1982; 17: 871-5.
    • (1982) Scand J Gastroenterol , vol.17 , pp. 871-875
    • Myren, J.1    Groth, H.2    Larssen, S.E.3    Larsen, S.4
  • 46
    • 0020521452 scopus 로고
    • Double blind trial of ispaghula/poloxamer in the irritable bowel syndrome
    • Arthurs Y, Fielding JF. Double blind trial of ispaghula/poloxamer in the irritable bowel syndrome. Ir Med J 1983; 76: 253.
    • (1983) Ir Med J , vol.76 , pp. 253
    • Arthurs, Y.1    Fielding, J.F.2
  • 47
    • 0020739162 scopus 로고
    • Evaluation of tricyclic compound (Timipramine) vis-a-vis placebo in irritable bowel syndrome. Double blind randomized study
    • Tripathi BM, Misra NP, Gupta AK. Evaluation of tricyclic compound (Timipramine) vis-a-vis placebo in irritable bowel syndrome. Double blind randomized study. J Assoc Physicians India 1983; 31: 201-3.
    • (1983) J Assoc Physicians India , vol.31 , pp. 201-203
    • Tripathi, B.M.1    Misra, N.P.2    Gupta, A.K.3
  • 48
    • 0020786544 scopus 로고
    • A double blind crossover study of diphenylhydantoin in irritable bowel syndrome
    • Chadda VS, Joshi KG, Chadda S. A double blind crossover study of diphenylhydantoin in irritable bowel syndrome. J Assoc Physicians India 1983; 31: 425-7.
    • (1983) J Assoc Physicians India , vol.31 , pp. 425-427
    • Chadda, V.S.1    Joshi, K.G.2    Chadda, S.3
  • 49
    • 0021729961 scopus 로고
    • Peppermint oil for the irritable bowel syndrome: A multicentre trial
    • Dew MJ, Evans BK, Rhodes J. Peppermint oil for the irritable bowel syndrome: a multicentre trial. Br J Clin Pract 1984; 38: 398.
    • (1984) Br J Clin Pract , vol.38 , pp. 398
    • Dew, M.J.1    Evans, B.K.2    Rhodes, J.3
  • 50
    • 0022481709 scopus 로고
    • Peppermint oil does not relieve the pain of irritable bowel syndrome
    • Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986; 40: 292-3.
    • (1986) Br J Clin Pract , vol.40 , pp. 292-293
    • Nash, P.1    Gould, S.R.2    Bernardo, D.E.3
  • 51
    • 0022921923 scopus 로고
    • Single drug treatment for irritable colon: Rociverine versus trimebutine maleate
    • Ghidini O, Saponati G, Intrieri L. Single drug treatment for irritable colon: rociverine versus trimebutine maleate. Curr Ther Res Clin Exp 1986; 39: 541-8.
    • (1986) Curr Ther Res Clin Exp , vol.39 , pp. 541-548
    • Ghidini, O.1    Saponati, G.2    Intrieri, L.3
  • 52
    • 0023640778 scopus 로고
    • Double blind study of ispaghula in irritable bowel syndrome
    • Prior A, Whorwell PJ. Double blind study of ispaghula in irritable bowel syndrome. Gut 1987; 28: 1510-3.
    • (1987) Gut , vol.28 , pp. 1510-1513
    • Prior, A.1    Whorwell, P.J.2
  • 53
    • 0023131398 scopus 로고
    • Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled crossover study
    • Lucey MR, Clark ML, Lowndes J, Dawson AM. Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled crossover study. Gut 1987; 28: 221-5.
    • (1987) Gut , vol.28 , pp. 221-225
    • Lucey, M.R.1    Clark, M.L.2    Lowndes, J.3    Dawson, A.M.4
  • 54
    • 0023136490 scopus 로고
    • Effects of desipramine on irritable bowel syndrome compared with atropine and placebo
    • Greenbaum DS, Mayle JE, Vanegeren LE et al. Effects of desipramine on irritable bowel syndrome compared with atropine and placebo. Dig Dis Sci 1987; 32: 257-66.
    • (1987) Dig Dis Sci , vol.32 , pp. 257-266
    • Greenbaum, D.S.1    Mayle, J.E.2    Vanegeren, L.E.3
  • 55
    • 0024179156 scopus 로고
    • Double-blind study of an alpha 2 agonist in the treatment of irritable bowel syndrome
    • Prior A, Wilson KM, Whorwell PJ. Double-blind study of an alpha 2 agonist in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 1988; 2: 535-9.
    • (1988) Aliment Pharmacol Ther , vol.2 , pp. 535-539
    • Prior, A.1    Wilson, K.M.2    Whorwell, P.J.3
  • 56
    • 0023732138 scopus 로고
    • Oral cimetropium bromide, a new antimuscarinic drug, for long-term treatment of irritable bowel syndrome
    • Centonze V, Imbimbo BP, Campanozzi F, Attolini E, Daniotti S, Albano O. Oral cimetropium bromide, a new antimuscarinic drug, for long-term treatment of irritable bowel syndrome. Am J Gastroenterol 1988; 83: 1262-6.
    • (1988) Am J Gastroenterol , vol.83 , pp. 1262-1266
    • Centonze, V.1    Imbimbo, B.P.2    Campanozzi, F.3    Attolini, E.4    Daniotti, S.5    Albano, O.6
  • 57
    • 0024809933 scopus 로고
    • The non-effect of pirenzepine in dietary resistant irritable bowel syndrome
    • Gilvarry J, Kenny A, Fielding JF. The non-effect of pirenzepine in dietary resistant irritable bowel syndrome. Ir J Med Sci 1989; 158: 262.
    • (1989) Ir J Med Sci , vol.158 , pp. 262
    • Gilvarry, J.1    Kenny, A.2    Fielding, J.F.3
  • 58
    • 0024942022 scopus 로고
    • Irritable bowel syndrome: Therapeutic evaluation of indigenous drugs
    • Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989; 90: 496-503.
    • (1989) Indian J Med Res , vol.90 , pp. 496-503
    • Yadav, S.K.1    Jain, A.K.2    Tripathi, S.N.3    Gupta, J.P.4
  • 59
    • 0025366666 scopus 로고
    • Long-term treatment of irritable bowel syndrome with cimetropium bromide: A double blind placebo controlled clinical trial
    • Dobrilla G, Imbimbo BP, Piazzi L, Bensi G. Long-term treatment of irritable bowel syndrome with cimetropium bromide: a double blind placebo controlled clinical trial. Gut 1990; 31: 355-8.
    • (1990) Gut , vol.31 , pp. 355-358
    • Dobrilla, G.1    Imbimbo, B.P.2    Piazzi, L.3    Bensi, G.4
  • 60
    • 0026015978 scopus 로고
    • 'Prokinetic' treatment of constipation-predominant irritable bowel syndrome: A placebo-controlled study of cisapride
    • Van Outryve M, Milo R, Toussaint J, Van Eeghem P. 'Prokinetic' treatment of constipation-predominant irritable bowel syndrome: a placebo-controlled study of cisapride. J Clin Gastroenterol 1991; 13: 49-57.
    • (1991) J Clin Gastroenterol , vol.13 , pp. 49-57
    • Van Outryve, M.1    Milo, R.2    Toussaint, J.3    Van Eeghem, P.4
  • 61
    • 0026516810 scopus 로고
    • Irritable bowel syndrome: Assessment of psychological disturbance and its influence on the response to fibre supplementation
    • Fowlie S, Eastwood MA, Prescott R. Irritable bowel syndrome: assessment of psychological disturbance and its influence on the response to fibre supplementation. J Psychosom Res 1992; 36: 175-80.
    • (1992) J Psychosom Res , vol.36 , pp. 175-180
    • Fowlie, S.1    Eastwood, M.A.2    Prescott, R.3
  • 62
    • 0028171608 scopus 로고
    • Bran supplementation in the treatment of irritable bowel syndrome
    • Snook J, Shepherd HA. Bran supplementation in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 1994; 8: 511-4.
    • (1994) Aliment Pharmacol Ther , vol.8 , pp. 511-514
    • Snook, J.1    Shepherd, H.A.2
  • 63
    • 0028238774 scopus 로고
    • Loxiglumide, a CCK-A antagonist, in irritable bowel syndrome. A pilot multicenter clinical study
    • Cann PA, Rovati LC, Smart HL, Spiller RC, Whorwell PJ. Loxiglumide, a CCK-A antagonist, in irritable bowel syndrome. A pilot multicenter clinical study. Ann N Y Acad Sci 1994; 713: 449-50.
    • (1994) Ann N Y Acad Sci , vol.713 , pp. 449-450
    • Cann, P.A.1    Rovati, L.C.2    Smart, H.L.3    Spiller, R.C.4    Whorwell, P.J.5
  • 64
    • 0029946003 scopus 로고    scopus 로고
    • A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome
    • Efskind PS, Bernklev T, Vatn MH. A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome. Scand J Gastroenterol 1996; 31: 463-8.
    • (1996) Scand J Gastroenterol , vol.31 , pp. 463-468
    • Efskind, P.S.1    Bernklev, T.2    Vatn, M.H.3
  • 65
    • 0030967149 scopus 로고    scopus 로고
    • Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome
    • Schutze K, Brandstatter G, Dragosics B, Judmaier G, Hentschel E. Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome. Aliment Pharmacol Ther 1997; 11: 387-94.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 387-394
    • Schutze, K.1    Brandstatter, G.2    Dragosics, B.3    Judmaier, G.4    Hentschel, E.5
  • 66
    • 0031663620 scopus 로고    scopus 로고
    • Otilonium bromide in irritable bowel syndrome: A double-blind, placebo-controlled, 15-week study
    • Battaglia G, Morselli-Labate AM, Camarri E et al. Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther 1998; 12: 1003-10.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 1003-1010
    • Battaglia, G.1    Morselli-Labate, A.M.2    Camarri, E.3
  • 68
    • 0034712539 scopus 로고    scopus 로고
    • Efficacy and safety of alosetron in women with irritable bowel syndrome: A randomised, placebo-controlled trial
    • Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet 2000; 355: 1035-40.
    • (2000) Lancet , vol.355 , pp. 1035-1040
    • Camilleri, M.1    Northcutt, A.R.2    Kong, S.3    Dukes, G.E.4    McSorley, D.5    Mangel, A.W.6
  • 69
    • 0034794595 scopus 로고    scopus 로고
    • Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
    • Muller-Lissner SA, Fumagalli I, Bardhan KD et al. Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther 2001; 15: 1655-66.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1655-1666
    • Muller-Lissner, S.A.1    Fumagalli, I.2    Bardhan, K.D.3
  • 70
    • 0034827794 scopus 로고    scopus 로고
    • Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome
    • Lembo T, Wright RA, Bagby B et al. Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001; 96: 2662-70.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2662-2670
    • Lembo, T.1    Wright, R.A.2    Bagby, B.3
  • 71
    • 0034917335 scopus 로고    scopus 로고
    • A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome
    • Camilleri M, Chey WY, Mayer EA et al. A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001; 161: 1733-40.
    • (2001) Arch Intern Med , vol.161 , pp. 1733-1740
    • Camilleri, M.1    Chey, W.Y.2    Mayer, E.A.3
  • 72
    • 0036829638 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation
    • Novick J, Miner P, Krause R et al. A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2002; 16: 1877-88.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1877-1888
    • Novick, J.1    Miner, P.2    Krause, R.3
  • 73
    • 0036766221 scopus 로고    scopus 로고
    • Charcoal tablets in the treatment of patients with irritable bowel syndrome
    • Hubner WD, Moser EH. Charcoal tablets in the treatment of patients with irritable bowel syndrome. Adv Ther 2002; 19: 245-52.
    • (2002) Adv Ther , vol.19 , pp. 245-252
    • Hubner, W.D.1    Moser, E.H.2
  • 74
    • 0036932020 scopus 로고    scopus 로고
    • Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome
    • Glende M, Morselli-Labate AM, Battaglia G, Evangelista S. Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome. Eur J Gastroenterol Hepatol 2002; 14: 1331-8.
    • (2002) Eur J Gastroenterol Hepatol , vol.14 , pp. 1331-1338
    • Glende, M.1    Morselli-Labate, A.M.2    Battaglia, G.3    Evangelista, S.4
  • 75
    • 0036897288 scopus 로고    scopus 로고
    • Patient satisfaction with alosetron for the treatment of women with diarrhea-predominant irritable bowel syndrome
    • Olden K, DeGarmo RG, Jhingran P et al. Patient satisfaction with alosetron for the treatment of women with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2002; 97: 3139-46.
    • (2002) Am J Gastroenterol , vol.97 , pp. 3139-3146
    • Olden, K.1    DeGarmo, R.G.2    Jhingran, P.3
  • 76
    • 0035999157 scopus 로고    scopus 로고
    • Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: Results of a double-blind, randomized, placebo-controlled trial
    • Mitchell SA, Mee AS, Smith GD, Palmer KR, Chapman RW. Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial. Aliment Pharmacol Ther 2002; 16: 1187-95.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1187-1195
    • Mitchell, S.A.1    Mee, A.S.2    Smith, G.D.3    Palmer, K.R.4    Chapman, R.W.5
  • 77
  • 78
    • 0141961575 scopus 로고    scopus 로고
    • A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome
    • Camilleri M, Kim D, McKinzie S et al. A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2003; 1: 111-21.
    • (2003) Clin Gastroenterol Hepatol , vol.1 , pp. 111-121
    • Camilleri, M.1    Kim, D.2    McKinzie, S.3


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