Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Kultti, Anne ^a   Zhao, Chunmei ^a   Singha, Netai C ^a   Zimmerman, Susan ^a   Osgood, Ryan J ^a   Symons, Rebecca ^a   Jiang, Ping ^a   Li, Xiaoming ^a   Thompson, Curtis B ^a   Infante, Jeffrey R ^b   Jacobetz, Michael A ^c   Tuveson, David A ^d   Frost, Gregory I ^e   Shepard, H Michael ^a   Huang, Zhongdong ^a  

^a Halozyme Therapeutics Inc   (United States)

^b SARAH CANNON RESEARCH INSTITUTE   (United States)

^c Labfinity   (United States)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e INTREXON CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; HYALURONAN SYNTHASE 3; HYALURONIC ACID; RECOMBINANT HYALURONIDASE; SYNTHETASE; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; GLUCURONOSYLTRANSFERASE; HAS2 PROTEIN, HUMAN; HAS3 PROTEIN, HUMAN; HYALURONOGLUCOSAMINIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PATIENT; CELL ADHESION; CELL JUNCTION; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; ANIMAL; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; BETA CATENIN; CADHERINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL LINE, TUMOR; GLUCURONOSYLTRANSFERASE; HUMANS; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; MICE; PANCREATIC NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84929014619     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/817613     Document Type: Article

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