Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor Protein Transgenic mice

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 5053-5064

  Jendresen, Charlotte B ^a   Cui, Hao ^b   Zhang, Xiao ^c   Vlodavsky, Israel ^d   Nilsson, Lars N G ^a   Li, Jin Ping ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; NEURODEGENERATIVE DISEASES; SULFUR COMPOUNDS;

ALZHEIMER DISEASE; DEGRADING ENZYMES; HEPARAN SULFATES; HEPARANASE; OVER-EXPRESSION; PRECURSOR PROTEINS; SENILE PLAQUES; TRANSGENIC MICE;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; HEPARANASE; PROTEOHEPARAN SULFATE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); APP PROTEIN, HUMAN; BETA GLUCURONIDASE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR PATHOLOGY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; STEADY STATE; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; BRAIN; GENETICS; HUMAN; METABOLISM; PATHOLOGY;

MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; GLUCURONIDASE; HUMANS; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS;

EID: 84929000422     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.600569     Document Type: Article

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