Understanding the limits of animal models as predictors of human biology: Lessons learned from the sbv IMPROVER Species Translation Challenge

Bioinformatics

Volumn 31, Issue 4, 2015, Pages 471-483

  Rhrissorrakrai, Kahn ^a   Belcastro, Vincenzo ^b,c   Bilal, Erhan ^a   Norel, Raquel ^a   Poussin, Carine ^b   Mathis, Carole ^b   Dulize, Remi H J ^b   Ivanov, Nikolai V ^b   Alexopoulos, Leonidas ^d,e   Jeremy Rice, J ^a   Peitsch, Manuel C ^b   Stolovitzky, Gustavo ^a   Meyer, Pablo ^a   Hoeng, Julia ^b  

^a IBM T J WATSON RESEARCH CENTER   (United States)

^b PHILIP MORRIS PRODUCTS S A   (Switzerland)

^c TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^d PROTATONCE LTD   (Greece)

^e NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; RATTUS; RODENTIA;

CYTOKINE; PHOSPHOPROTEIN;

ALGORITHM; ANIMAL; ANIMAL MODEL; BRONCHUS; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DNA MICROARRAY; EPITHELIUM CELL; FACTUAL DATABASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; HUMAN; METABOLISM; PHOSPHORYLATION; PROCEDURES; RAT; SOFTWARE; SPECIES DIFFERENCE; SYSTEMS BIOLOGY; TRANSLATIONAL RESEARCH;

ALGORITHMS; ANIMALS; BRONCHI; CELLS, CULTURED; CYTOKINES; DATABASES, FACTUAL; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MODELS, ANIMAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; SOFTWARE; SPECIES SPECIFICITY; SYSTEMS BIOLOGY; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84928996609     PISSN: 13674803     EISSN: 14602059     Source Type: Journal    
DOI: 10.1093/bioinformatics/btu611     Document Type: Article

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