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Volumn 12, Issue 1, 2015, Pages

Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice

Author keywords

E cigarettes; Focal ischemia; Glucose transporter 1; Ischemia reperfusion; Middle cerebral artery occlusion; Nicotine; Stroke; Tobacco smoke

Indexed keywords

GLUCOSE TRANSPORTER 1; NICOTINE; GLUCOSE BLOOD LEVEL;

EID: 84928981955     PISSN: None     EISSN: 20458118     Source Type: Journal    
DOI: 10.1186/s12987-015-0005-y     Document Type: Article
Times cited : (29)

References (54)
  • 1
    • 84893651437 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2014 update: a report from the American Heart Association
    • Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28-292.
    • (2014) Circulation , vol.129 , Issue.3 , pp. e28-292
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3    Benjamin, E.J.4    Berry, J.D.5    Blaha, M.J.6
  • 2
    • 80052962669 scopus 로고    scopus 로고
    • Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy
    • Etter JF, Bullen C. Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy. Addiction. 2011;106(11):2017-28.
    • (2011) Addiction , vol.106 , Issue.11 , pp. 2017-2028
    • Etter, J.F.1    Bullen, C.2
  • 3
    • 84867812582 scopus 로고    scopus 로고
    • The role of glucose transporters in brain disease: diabetes and Alzheimer's Disease
    • Shah K, Desilva S, Abbruscato T. The role of glucose transporters in brain disease: diabetes and Alzheimer's Disease. Int J Mol Sci. 2012;13(10):12629-55.
    • (2012) Int J Mol Sci , vol.13 , Issue.10 , pp. 12629-12655
    • Shah, K.1    Desilva, S.2    Abbruscato, T.3
  • 5
    • 0028988818 scopus 로고
    • Review: does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI
    • Jueptner M, Weiller C. Review: does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI. NeuroImage. 1995;2(2):148-56.
    • (1995) NeuroImage , vol.2 , Issue.2 , pp. 148-156
    • Jueptner, M.1    Weiller, C.2
  • 6
    • 84897472698 scopus 로고    scopus 로고
    • The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke
    • Shah K, Abbruscato T. The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke. Curr Pharm Des. 2014;20(10):1510-22.
    • (2014) Curr Pharm Des , vol.20 , Issue.10 , pp. 1510-1522
    • Shah, K.1    Abbruscato, T.2
  • 7
    • 0029884716 scopus 로고    scopus 로고
    • Expression of glucose transporters in rat brain following transient focal ischemic injury
    • Urabe T, Hattori N, Nagamatsu S, Sawa H, Mizuno Y. Expression of glucose transporters in rat brain following transient focal ischemic injury. J Neurochem. 1996;67(1):265-71.
    • (1996) J Neurochem , vol.67 , Issue.1 , pp. 265-271
    • Urabe, T.1    Hattori, N.2    Nagamatsu, S.3    Sawa, H.4    Mizuno, Y.5
  • 8
    • 58849143505 scopus 로고    scopus 로고
    • Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity
    • Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, et al. Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity. Neurocrit Care. 2008;9(3):319-25.
    • (2008) Neurocrit Care , vol.9 , Issue.3 , pp. 319-325
    • Abate, M.G.1    Trivedi, M.2    Fryer, T.D.3    Smielewski, P.4    Chatfield, D.A.5    Williams, G.B.6
  • 10
    • 0030051010 scopus 로고    scopus 로고
    • Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain
    • Vannucci SJ, Seaman LB, Vannucci RC. Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain. J Cereb Blood Flow Metab. 1996;16(1):77-81.
    • (1996) J Cereb Blood Flow Metab , vol.16 , Issue.1 , pp. 77-81
    • Vannucci, S.J.1    Seaman, L.B.2    Vannucci, R.C.3
  • 11
    • 37349023393 scopus 로고    scopus 로고
    • Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia
    • Yeh WL, Lin CJ, Fu WM. Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia. Mol Pharmacol. 2008;73(1):170-7.
    • (2008) Mol Pharmacol , vol.73 , Issue.1 , pp. 170-177
    • Yeh, W.L.1    Lin, C.J.2    Fu, W.M.3
  • 13
    • 0036891988 scopus 로고    scopus 로고
    • Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells
    • Abbruscato TJ, Lopez SP, Mark KS, Hawkins BT, Davis TP. Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. J Pharm Sci. 2002;91(12):2525-38.
    • (2002) J Pharm Sci , vol.91 , Issue.12 , pp. 2525-2538
    • Abbruscato, T.J.1    Lopez, S.P.2    Mark, K.S.3    Hawkins, B.T.4    Davis, T.P.5
  • 14
    • 3343007152 scopus 로고    scopus 로고
    • Regulation of blood-brain barrier Na,K,2Cl-cotransporter through phosphorylation during in vitro stroke conditions and nicotine exposure
    • Abbruscato TJ, Lopez SP, Roder K, Paulson JR. Regulation of blood-brain barrier Na,K,2Cl-cotransporter through phosphorylation during in vitro stroke conditions and nicotine exposure. J Pharmacol Exp Ther. 2004;310(2):459-68.
    • (2004) J Pharmacol Exp Ther , vol.310 , Issue.2 , pp. 459-468
    • Abbruscato, T.J.1    Lopez, S.P.2    Roder, K.3    Paulson, J.R.4
  • 17
    • 0028174956 scopus 로고
    • Nicotine downregulates alpha 2 isoform of Na, K-ATPase at the blood-brain barrier and brain in rats
    • Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na, K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994;199(3):1422-7.
    • (1994) Biochem Biophys Res Commun , vol.199 , Issue.3 , pp. 1422-1427
    • Wang, L.1    McComb, J.G.2    Weiss, M.H.3    McDonough, A.A.4    Zlokovic, B.V.5
  • 18
    • 0027141682 scopus 로고
    • Nicotine increases microvascular blood flow and flow velocity in three groups of brain areas
    • Hans FJ, Wei L, Bereczki D, Acuff V, Demaro J, Chen JL, et al. Nicotine increases microvascular blood flow and flow velocity in three groups of brain areas. Am J Physiol. 1993;265(6 Pt 2):H2142-50.
    • (1993) Am J Physiol , vol.265 , Issue.6 , pp. H2142-H2150
    • Hans, F.J.1    Wei, L.2    Bereczki, D.3    Acuff, V.4    Demaro, J.5    Chen, J.L.6
  • 19
    • 5644226650 scopus 로고    scopus 로고
    • Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution
    • Hawkins BT, Abbruscato TJ, Egleton RD, Brown RC, Huber JD, Campos CR, et al. Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Brain Res. 2004;1027(1-2):48-58. doi:10.1016/j.brainres.2004.08.043.
    • (2004) Brain Res , vol.1027 , Issue.1-2 , pp. 48-58
    • Hawkins, B.T.1    Abbruscato, T.J.2    Egleton, R.D.3    Brown, R.C.4    Huber, J.D.5    Campos, C.R.6
  • 21
    • 0023791214 scopus 로고
    • The effect of an acute nicotine infusion on the local cerebral glucose utilization of the awake rat
    • Grunwald F, Schrock H, Kuschinsky W. The effect of an acute nicotine infusion on the local cerebral glucose utilization of the awake rat. Klin Wochenschr. 1988;66 Suppl 11:37-41.
    • (1988) Klin Wochenschr , vol.66 , pp. 37-41
    • Grunwald, F.1    Schrock, H.2    Kuschinsky, W.3
  • 22
    • 0032567719 scopus 로고    scopus 로고
    • Increase of glucose transporter densities (Glut1 and Glut3) during chronic administration of nicotine in rat brain
    • Duelli R, Staudt R, Grunwald F, Kuschinsky W. Increase of glucose transporter densities (Glut1 and Glut3) during chronic administration of nicotine in rat brain. Brain Res. 1998;782(1-2):36-42.
    • (1998) Brain Res , vol.782 , Issue.1-2 , pp. 36-42
    • Duelli, R.1    Staudt, R.2    Grunwald, F.3    Kuschinsky, W.4
  • 23
    • 0031768725 scopus 로고    scopus 로고
    • Local transport kinetics of glucose during acute and chronic nicotine infusion in rat brains
    • Duelli R, Staudt R, Maurer MH, Kuschinsky W. Local transport kinetics of glucose during acute and chronic nicotine infusion in rat brains. J Neural Transm. 1998;105(8-9):1017-28.
    • (1998) J Neural Transm , vol.105 , Issue.8-9 , pp. 1017-1028
    • Duelli, R.1    Staudt, R.2    Maurer, M.H.3    Kuschinsky, W.4
  • 24
    • 0023206055 scopus 로고
    • The effect of an acute nicotine infusion on the local cerebral glucose utilization of the awake rat
    • Grunwald F, Schrock H, Kuschinsky W. The effect of an acute nicotine infusion on the local cerebral glucose utilization of the awake rat. Brain Res. 1987;400(2):232-8.
    • (1987) Brain Res , vol.400 , Issue.2 , pp. 232-238
    • Grunwald, F.1    Schrock, H.2    Kuschinsky, W.3
  • 25
    • 0034619443 scopus 로고    scopus 로고
    • Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers
    • Domino EF, Minoshima S, Guthrie SK, Ohl L, Ni L, Koeppe RA, et al. Effects of nicotine on regional cerebral glucose metabolism in awake resting tobacco smokers. Neuroscience. 2000;101(2):277-82.
    • (2000) Neuroscience , vol.101 , Issue.2 , pp. 277-282
    • Domino, E.F.1    Minoshima, S.2    Guthrie, S.K.3    Ohl, L.4    Ni, L.5    Koeppe, R.A.6
  • 28
    • 84897109081 scopus 로고    scopus 로고
    • Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain
    • Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscato TJ, et al. Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain. J Neurochem. 2014;129(1):179-89.
    • (2014) J Neurochem , vol.129 , Issue.1 , pp. 179-189
    • Rashid, M.1    Wangler, N.J.2    Yang, L.3    Shah, K.4    Arumugam, T.V.5    Abbruscato, T.J.6
  • 29
    • 80054783113 scopus 로고    scopus 로고
    • Characterization of neuroprotective effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia
    • Yang L, Shah K, Wang H, Karamyan VT, Abbruscato TJ. Characterization of neuroprotective effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia. J Pharmacol Exp Ther. 2011;339(2):499-508.
    • (2011) J Pharmacol Exp Ther , vol.339 , Issue.2 , pp. 499-508
    • Yang, L.1    Shah, K.2    Wang, H.3    Karamyan, V.T.4    Abbruscato, T.J.5
  • 31
    • 0642311330 scopus 로고    scopus 로고
    • In situ brain perfusion technique
    • Smith QR, Allen DD. In situ brain perfusion technique. Methods Mol Med. 2003;89:209-18. doi:10.1385/1-59259-419-0:209.
    • (2003) Methods Mol Med , vol.89 , pp. 209-218
    • Smith, Q.R.1    Allen, D.D.2
  • 32
    • 0023196669 scopus 로고
    • Effects of insulin on hexose transport across blood-brain barrier in normoglycemia
    • Namba H, Lucignani G, Nehlig A, Patlak C, Pettigrew K, Kennedy C, et al. Effects of insulin on hexose transport across blood-brain barrier in normoglycemia. Am J Physiol. 1987;252(3 Pt 1):E299-303.
    • (1987) Am J Physiol , vol.252 , Issue.3 , pp. E299-E303
    • Namba, H.1    Lucignani, G.2    Nehlig, A.3    Patlak, C.4    Pettigrew, K.5    Kennedy, C.6
  • 33
    • 0032898973 scopus 로고    scopus 로고
    • Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited
    • Simpson IA, Appel NM, Hokari M, Oki J, Holman GD, Maher F, et al. Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. J Neurochem. 1999;72(1):238-47.
    • (1999) J Neurochem , vol.72 , Issue.1 , pp. 238-247
    • Simpson, I.A.1    Appel, N.M.2    Hokari, M.3    Oki, J.4    Holman, G.D.5    Maher, F.6
  • 34
    • 0028095189 scopus 로고
    • Hypoxia increases glucose transport at blood-brain barrier in rats
    • Harik SI, Behmand RA, LaManna JC. Hypoxia increases glucose transport at blood-brain barrier in rats. J Appl Physiol. 1994;77(2):896-901.
    • (1994) J Appl Physiol , vol.77 , Issue.2 , pp. 896-901
    • Harik, S.I.1    Behmand, R.A.2    LaManna, J.C.3
  • 36
    • 84920182944 scopus 로고    scopus 로고
    • NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke
    • Brennan-Minnella AM, Won SJ, Swanson RA. NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke. Antioxid Redox Signal. 2015;22(2):161-74.
    • (2015) Antioxid Redox Signal , vol.22 , Issue.2 , pp. 161-174
    • Brennan-Minnella, A.M.1    Won, S.J.2    Swanson, R.A.3
  • 37
    • 84863935926 scopus 로고    scopus 로고
    • Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain
    • Wu F, Wu J, Nicholson AD, Echeverry R, Haile WB, Catano M, et al. Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain. J Neurosci. 2012;32(29):9848-58.
    • (2012) J Neurosci , vol.32 , Issue.29 , pp. 9848-9858
    • Wu, F.1    Wu, J.2    Nicholson, A.D.3    Echeverry, R.4    Haile, W.B.5    Catano, M.6
  • 38
    • 60549108722 scopus 로고    scopus 로고
    • The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study
    • Fuentes B, Castillo J, San Jose B, Leira R, Serena J, Vivancos J, et al. The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study. Stroke. 2009;40(2):562-8.
    • (2009) Stroke , vol.40 , Issue.2 , pp. 562-568
    • Fuentes, B.1    Castillo, J.2    San Jose, B.3    Leira, R.4    Serena, J.5    Vivancos, J.6
  • 39
    • 77949491218 scopus 로고    scopus 로고
    • Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management
    • Kruyt ND, Biessels GJ, Devries JH, Roos YB. Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management. Nat Rev Neurol. 2010;6(3):145-55.
    • (2010) Nat Rev Neurol , vol.6 , Issue.3 , pp. 145-155
    • Kruyt, N.D.1    Biessels, G.J.2    Devries, J.H.3    Roos, Y.B.4
  • 40
    • 0032894044 scopus 로고    scopus 로고
    • Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST)
    • Scott JF, Robinson GM, French JM, O'Connell JE, Alberti KG, Gray CS. Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST). Stroke. 1999;30(4):793-9.
    • (1999) Stroke , vol.30 , Issue.4 , pp. 793-799
    • Scott, J.F.1    Robinson, G.M.2    French, J.M.3    O'Connell, J.E.4    Alberti, K.G.5    Gray, C.S.6
  • 42
    • 39349094881 scopus 로고    scopus 로고
    • Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial
    • Bruno A, Kent TA, Coull BM, Shankar RR, Saha C, Becker KJ, et al. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke. 2008;39(2):384-9.
    • (2008) Stroke , vol.39 , Issue.2 , pp. 384-389
    • Bruno, A.1    Kent, T.A.2    Coull, B.M.3    Shankar, R.R.4    Saha, C.5    Becker, K.J.6
  • 44
    • 79951880894 scopus 로고    scopus 로고
    • Intravenous insulin therapy in the maintenance of strict glycemic control in nondiabetic acute stroke patients with mild hyperglycemia
    • Staszewski J, Brodacki B, Kotowicz J, Stepien A. Intravenous insulin therapy in the maintenance of strict glycemic control in nondiabetic acute stroke patients with mild hyperglycemia. J Stroke Cerebrovasc Dis. 2011;20(2):150-4.
    • (2011) J Stroke Cerebrovasc Dis , vol.20 , Issue.2 , pp. 150-154
    • Staszewski, J.1    Brodacki, B.2    Kotowicz, J.3    Stepien, A.4
  • 45
    • 80055089305 scopus 로고    scopus 로고
    • Insulin for glycaemic control in acute ischaemic stroke
    • Bellolio MF, Gilmore RM, Stead LG. Insulin for glycaemic control in acute ischaemic stroke. Cochrane Database Syst Rev. 2011;9:CD005346. doi:10.1002/14651858.CD005346.pub3.
    • (2011) Cochrane Database Syst Rev , vol.9 , pp. CD005346
    • Bellolio, M.F.1    Gilmore, R.M.2    Stead, L.G.3
  • 46
    • 32544433631 scopus 로고    scopus 로고
    • Protein kinase C family members as a target for regulation of blood-brain barrier Na, K,2Cl-cotransporter during in vitro stroke conditions and nicotine exposure
    • Yang T, Roder KE, Bhat GJ, Thekkumkara TJ, Abbruscato TJ. Protein kinase C family members as a target for regulation of blood-brain barrier Na, K,2Cl-cotransporter during in vitro stroke conditions and nicotine exposure. Pharm Res. 2006;23(2):291-302.
    • (2006) Pharm Res , vol.23 , Issue.2 , pp. 291-302
    • Yang, T.1    Roder, K.E.2    Bhat, G.J.3    Thekkumkara, T.J.4    Abbruscato, T.J.5
  • 47
    • 34547663520 scopus 로고    scopus 로고
    • Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes
    • Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower Jr WR, et al. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest. 2007;117(8):2289-301.
    • (2007) J Clin Invest , vol.117 , Issue.8 , pp. 2289-2301
    • Farese, R.V.1    Sajan, M.P.2    Yang, H.3    Li, P.4    Mastorides, S.5    Gower, W.R.6
  • 48
    • 0034999443 scopus 로고    scopus 로고
    • Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation
    • DeBosch BJ, Baur E, Deo BK, Hiraoka M, Kumagai AK. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67.
    • (2001) J Neurochem , vol.77 , Issue.4 , pp. 1157-1167
    • DeBosch, B.J.1    Baur, E.2    Deo, B.K.3    Hiraoka, M.4    Kumagai, A.K.5
  • 49
    • 0026553539 scopus 로고
    • GLUT-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular endothelia with and without tight junctions
    • Farrell CL, Yang J, Pardridge WM. GLUT-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular endothelia with and without tight junctions. J Histochem Cytochem. 1992;40(2):193-9.
    • (1992) J Histochem Cytochem , vol.40 , Issue.2 , pp. 193-199
    • Farrell, C.L.1    Yang, J.2    Pardridge, W.M.3
  • 50
    • 0034043043 scopus 로고    scopus 로고
    • Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells
    • Sone H, Deo BK, Kumagai AK. Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells. Invest Ophthalmol Vis Sci. 2000;41(7):1876-84.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , Issue.7 , pp. 1876-1884
    • Sone, H.1    Deo, B.K.2    Kumagai, A.K.3
  • 51
    • 12344337754 scopus 로고    scopus 로고
    • Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy
    • Cornford EM, Hyman S. Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy. NeuroRx. 2005;2(1):27-43.
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 27-43
    • Cornford, E.M.1    Hyman, S.2
  • 52
    • 0026493905 scopus 로고
    • Long-term nicotine exposure increases aortic endothelial cell death and enhances transendothelial macromolecular transport in rats
    • Lin SJ, Hong CY, Chang MS, Chiang BN, Chien S. Long-term nicotine exposure increases aortic endothelial cell death and enhances transendothelial macromolecular transport in rats. Arterioscler Thromb. 1992;12(11):1305-12.
    • (1992) Arterioscler Thromb , vol.12 , Issue.11 , pp. 1305-1312
    • Lin, S.J.1    Hong, C.Y.2    Chang, M.S.3    Chiang, B.N.4    Chien, S.5
  • 53
    • 21344449291 scopus 로고    scopus 로고
    • Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine
    • Lockman PR, Van der Schyf CJ, Abbruscato TJ, Allen DD. Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. J Neurochem. 2005;94(1):37-44.
    • (2005) J Neurochem , vol.94 , Issue.1 , pp. 37-44
    • Lockman, P.R.1    Schyf, C.J.2    Abbruscato, T.J.3    Allen, D.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.