Intravenous insulin therapy in the maintenance of strict glycemic control in nondiabetic acute stroke patients with mild hyperglycemia

Journal of Stroke and Cerebrovascular Diseases

Volumn 20, Issue 2, 2011, Pages 150-154

  Staszewski, Jacek ^a   Brodacki, Bogdan ^a   Kotowicz, Jerzy ^a   Stepien, Adam ^a  

^a MILITARY INSTITUTE OF MEDICINE   (Poland)

Author keywords

glycemic control; hyperglycemia; insulin; Ischemic stroke; stroke outcome; treatment

Indexed keywords

GLUCOSE; INSULIN;

ACUTE DISEASE; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; DIABETES MELLITUS; DISEASE SEVERITY; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN TREATMENT; MALE; NEUROMONITORING; PRIORITY JOURNAL; RATING SCALE; RISK FACTOR; SCORING SYSTEM; STROKE; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; CHI-SQUARE DISTRIBUTION; DISABILITY EVALUATION; FEMALE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; INSULIN; LOGISTIC MODELS; MALE; MIDDLE AGED; POLAND; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STROKE; TIME FACTORS; TREATMENT OUTCOME;

EID: 79951880894     PISSN: 10523057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2009.11.013     Document Type: Article

References (18)

1. Michel P. General principles of acute stroke management. In: Fisher M, ed. Handbook of Clinical Neurology, Vol 94, Stroke, part III. Amsterdam: Elsevier, 2009:1129-1154.
2. Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001;32:2426-2432. (Pubitemid 32954818)
3. Kawai N, Keep RF, Betz AL. Hyperglycemia and the vascular effects of cerebral ischemia. Stroke 1997;28:149-154. (Pubitemid 27039479)
4. Candelise L, Landi G, Orazio E, et al. Prognostic significance of hyperglycemia in acute stroke. Arch Neurol 1985;45:661-663. (Pubitemid 15062821)
5. European Stroke Organization (ESO) Executive Committee and the ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischemic attack, 2008. Cerebrovasc Dis 2008;25:457-507.
6. Keirs L, Davis SM, Larkins R, et al. Stroke topography and outcome in relation to hyperglycemia and diabetes. J Neurol Neurosurg Psychiatry 1992;52:263-270.
7. Kent TA, Soukup VM, Fabian RH. Heterogeneity affecting outcome from acute stroke therapy: Making reperfusion worse. Stroke 2001;32:2318-2327. (Pubitemid 32954803)
8. Parsons MW, Barber PA, Desmond PM, et al. Acute hyperglycemia adversely affects stroke outcome: A magnetic resonance imaging and spectroscopy study. Ann Neurol 2002;52:20-28. (Pubitemid 34693739)
9. Pulsinelli W, Waldman S, Rawlinson D, et al. Moderate hyperglycemia augments ischemic brain damage: A neuropathologic study in the rat. Neurology 1982;32:1239-1246.
10. Marsh R, Anderson R, Sundt T. Effect of hyperglycemia on brain pH levels in areas of local incomplete cerebral ischemia in monkeys. J Neurosurg 1986;65:693-696. (Pubitemid 17177521)
11. Hamilton MG, Tranmer BI, Auer RN. Insulin reduction of cerebral infarction due to transient focal ischemia. J Neurosurg 1995;82:262-268.
12. Izumi Y, Pinard E, Roussel S, et al. Insulin protects brain tissue against focal cerebral ischemia in rats. Neurosci Lett 1995;197:53-56.
13. Malmerberg K, Rydern L, Efendic S, et al. Randomised trial of insulin glucose infusion followed by subcutaneus insulin treatment in diabetic patients with acute myocardial infarction. J Am Coll Cardiol 1995;26:57-65.
14. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359-1367.
15. Gray CS, Hildreth AJ, Alberti GKMM, et al. Poststroke hyperglycemia: natural history and immediate management. Stroke 2004;35:122-126. (Pubitemid 38057604)
16. Walters MR, Weir CJ, Lees KR. A randomized, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycemic acute stroke patients. Cerebrovasc Dis 2006;22:116-122. (Pubitemid 44114452)
17. Gray CS, Hildreth AJ, Sandercock PA, et al. Glucose-potassium-insulin infusions in the management of poststroke hyperglycemia: The UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol 2007;6:397-406. (Pubitemid 46551852)
18. Bruno A, Kent TA, Coull BM, et al. Treatment of hyperglycemia in ischemic stroke (THIS): A randomized pilot trial. Stroke 2008;39:384-389. (Pubitemid 351619460)