Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 1, 1996, Pages 77-81

  Vannucci, Susan J ^a   Seaman, Lisa B ^a   Vannucci, Robert C ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Glucose metabolism; Glucose transporters; Hypoxia ischemia; Perinatal rat

Indexed keywords

GLUCOSE TRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE BRAIN LEVEL; GLUCOSE TRANSPORT SYSTEM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT;

EID: 0030051010     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199601000-00009     Document Type: Article

References (20)

1. Betz AL, Goldstein GW (1981) Developmental changes in metabolism and transport properties of capillaries isolated from rat brain. J Physiol (Lond) 312:365-376
2. Harik SI, Behmand RA, LaManna JC (1994) Hypoxia increases glucose transport at blood-brain barrier in rats. J Appl Physiol 77:896-901
3. Honer WG, Hu L, Davies P (1993) Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res 609:9-20
4. Loike JD, Cao L, Brett J, Ogawa S, Silverstein SC (1992) Hypoxia induces glucose transporter expression in endothelial cells. Am J Physiol 263 (Cell Physiol 32):C326-C333
5. Maher F, Vannucci SJ, Takeda J, Simpson IA (1992) Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain. Biochem Biophys Res Commun 182:703-711
6. Maher F, Vannucci SJ, Simpson IA (1993) Glucose transporter isoforms in brain: Absence of GLUT3 from the blood-brain barrier. J Cereb Blood Flow Metab 13:342-345
7. Maher F, Simpson IA (1994) Modulation of expression of glucose transporters, GLUT3 and GLUT1, by potassium and N-methyl-D-aspartate in cultured cerebellar granule neurons. Mol Cell Neurosci 5:369-375
8. Maher F, Vannucci SJ, Simpson IA (1994) Glucose transporter proteins in brain. FASEB J 8:1003-1011
9. Murakami T, Nishiyama T, Shirotani T, Shinohara T, Kan Y, Ishii M, Kanai K, Nakazuru F, Ebina Y (1992) Identification of two enhancer elements in the gene encoding the type I glucose transporter from the mouse which are responsive to serum, growth factor and oncogenes. J Biol Chem 267:9300-9306
10. Palmer C, Brucklacher RM, Christensen MA, Vannucci RC (1990) Carbohydrate and energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 10:227-235
11. Raichle ME (1983) The pathophysiology of brain ischemia. Ann Neurol 11:499-509
12. Rice JE, Vannucci RC, Brierley JB (1981) The influence of immaturity on hypoxic-ischemia brain damage in the rat. Ann Neural 9:131-141
13. Siesjo BK (1981) Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab 1:155-185
14. Vannucci RC, Christenson MA, Stein DT (1989) Regional cereboral glucose utilization in the immature rat: effect of hypoxia-ischemia. Pediatr Res 26:208-214
15. Vannucci RC (1990) Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. Pediatr Res 27:317-326
16. Vannucci SJ (1994) Developmental expression of GLUT1 and GLUT3 glucose transporters in rat brain. J Neurochem 62:240-246
17. Vannucci RC, Yager JY, Vannucci SJ (1994a) Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 14:279-288
18. Vannucci SJ, Maher F, Koehler E, Simpson IA (1994b) Altered expression of GLUT1 and GLUT3 glucose transporters in the neurohypophysis of water-deprived or diabetic rats. Am J Physiol 261:E605-E611
19. Vannucci SJ, Seaman LB, Brucklacher RM, Vannucci RC (1994c) Glucose transport in developing rat brain: Glucose transporter proteins, rate constants and cerebral glucose utilization. Mol Cell Biochem 140:177-184
20. Wertheimer E, Sasson S, Cerasi E, Ben-Neriah Y (1991) The ubiquitous glucose transporter GLUT1 belongs to the glucose-regulated family of stress-inducible proteins. Proc Natl Acad Sci USA 88:2525-2529