Increase of glucose transporter densities (Glut1 and Glut3) during chronic administration of nicotine in rat brain

Brain Research

Volumn 782, Issue 1-2, 1998, Pages 36-42

  Duelli, Roman ^a   Staudt, Richard ^a   Grünwald, Frank ^b   Kuschinsky, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Autoradiography; Brain capillary; Chronic nicotine; Immunostaining; Local cerebral glucose utilization

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CAPILLARY DENSITY; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY;

ANIMALS; AUTORADIOGRAPHY; BODY WEIGHT; BRAIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 3; INFUSION PUMPS; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0032567719     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01264-X     Document Type: Article

References (25)

1. Bondy C.A., Lee W.H., Zhou J. Ontogeny and cellular distribution of brain glucose transporter gene expression. Mol. Cell Neurosci. 3:1992;305-314.
2. Brant A.M., Jess T.M., Milligam G., Brown C.M., Gould G.W. Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system. Biochem. Biophys. Res. Commun. 192:1993;1297-1302.
3. Feyerabend C. A rapid gas-liquid chromatographic method for determination of cotinine and nicotine in biological fluids. J. Pharm. Pharmacol. 42:1990;450-452.
4. Gerhart D.Z., LeVasseur R.J., Broderius M.A., Drewes L.R. Glucose transporter localization in brain using light and electron immunocytochemistry. J. Neurosci. Res. 22:1989;464-472.
5. Göbel U., Theilen H., Kuschinsky W. Congruence of total and perfused capillary network in rat brains. Circ. Res. 66:1990;271-281.
6. Grünwald F., Schröck H., Theilen H., Biber A., Kuschinsky W. Local cerebral glucose utilization of the awake rat during chronic administration of nicotine. Brain Res. 456:1988;350-356.
7. Harik N., Harik S.I., Kuo N.T., Sakai K., Przybylski R.J., LaManna J.C. Time-course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter density. Brain Res. 737:1997;335-338.
8. Harik S.I., Kalaria R.N., Andersson L., Lundahl P., Perry G. Immunocytochemical localization of the erythroid glucose transporter: Abundance in tissues with barrier functions. J. Neurosci. 10:1990;3862-3872.
9. Isaacs K.R., Anderson B.J., Alcantara A.A., Black J.E., Greenough W.T. Exercise and the brain: Angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. J. Cereb. Blood Flow Metab. 12:1992;110-119.
10. Klein B., Kuschinsky W., Schröck H., Vetterlein F. Interdependency of local capillary density, blood flow and metabolism in rat brains. Am. J. Physiol. 251:1986;H1333-H1340.
11. Kumagai A.K., Dwyer K.J., Pardridge W.M. Differential glycosylation of the Glut1 glucose transporter in brain capillaries and choroid plexus. Biochim. Biophys. Acta. 1193:1994;24-30.
12. London E.D., Fanelli R.J., Kimes A.S., Moses R.L. Effects of nicotine on cerebral glucose utilization in the rat. Brain Res. 520:1990;208-214.
13. Maher F., Vannucci S.J., Simpson I.A. Glucose transporter isoforms in the brain: Absence of Glut3 from the blood-brain barrier. J. Cereb. Blood Flow Metab. 13:1993;342-345.
14. Maher F., Vannucci S.J., Simpson I.A. Glucose transporter proteins in the brain. FASEB J. 8:1994;1003-1011.
15. McCall A.L., Van Bueren A.M., Moholt-Siebert M., Cherry N.J., Woodward W.R. Immunohistochemical localization of the neuron-specific glucose transporter (Glut3) to neuropil in adult rat brain. Brain Res. 659:1994;292-297.
16. Monteggia L.M., Arneric S.P., Giordano T. Nicotine effects on the regulation of amyloid precursor protein splicing, neurotrophin and glucose transporter RNA levels in aged rats. Int. J. Dev. Neurosci. 12:1994;133-142.
17. Murrin L.C., Ferrer J.R., Zeng W.Y., Haley N.J. Nicotine administration to rats: Methodological considerations. Life Sci. 40:1987;1699-1708.
18. Nagamatsu S., Kornhauser J.M., Burant C.F., Seino S., Mayo K.E., Bell G.I. Glucose transporter expression in the brain: cDNA sequence of mouse Glut3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization. J. Biol. Chem. 267:1992;467-472.
19. Nagamatsu S., Sawa H., Kamada K., Nakamichi Y., Yoshimoto K., Hoshino T. Neuron-specific glucose transporter (NSGT): CNS distribution of Glut3 rat glucose transporter (RGT3) in rat central neurons. FEBS Lett. 334:1993;289-295.
20. 14C)deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anaesthetized albino rat. J. Neurochem. 28:1977;897-916.
21. Theilen H., Kuschinsky W. Fluorescence labelling of the capillary network in rat brains. J. Cereb. Blood Flow Metab. 12:1992;347-350.
22. Wang L., Kittaka M., Sun N., Schreiber S.S., Zlokovic B.V. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J. Cereb. Blood Flow Metab. 17:1997;136-146.
23. Young J.K., Wang C. Glucose transporter immunoreactivity in the hypothalamus and area postrema. Brain Res. Bull. 24:1990;525-528.
24. Zeller K., Duelli R., Vogel J., Schröck H., Kuschinsky W. Autoradiographic analysis of the regional distribution of Glut3 glucose transporters in the rat brain. Brain Res. 698:1995;175-179.
25. Zeller K., Rahner-Welsch S., Kuschinsky W. The distribution of Glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brains. J. Cereb. Blood Flow Metab. 17:1997;204-209.