Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5685-5690

  Kmita, Katarzyna ^a   Wirth, Christophe ^b   Warnau, Judith ^c   Guerrero Castillo, Sergio ^a,d   Hunte, Carola ^b   Hummer, Gerhard ^c   Kaila, Ville R I ^e   Zwicker, Klaus ^a   Brandt, Ulrich ^a,d   Zickermann, Volker ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Assembly; FeS cluster; Metal protein; NDUFA12; NDUFAF2

Indexed keywords

HYDROGEN; IRON SULFUR PROTEIN; MEMBRANE PROTEIN; METAL; NDUFS6 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; ZINC; CHAPERONE; NDUFS6 PROTEIN, HUMAN; PROTEIN BINDING; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; BINDING SITE; BIOGENESIS; CARBOXY TERMINAL SEQUENCE; CHROMOSOME DELETION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME ACTIVITY; FUNGAL GENOME; HUMAN; HYDROGEN BOND; MITOCHONDRIAL MEMBRANE; MOLECULAR WEIGHT; NEUROSPORA CRASSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; QUANTUM MECHANICS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; TAURINE CATTLE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; X RAY FLUORESCENCE; YARROWIA LIPOLYTICA; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; ELECTROPHORESIS; GENE DELETION; METABOLISM; MITOCHONDRION; MUTATION; PROTEIN TERTIARY STRUCTURE; PROTEOMICS; SPECTROPHOTOMETRY;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRON TRANSPORT COMPLEX I; ELECTROPHORESIS; GENE DELETION; HUMANS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MOLECULAR CHAPERONES; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADH DEHYDROGENASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOMICS; SPECTROPHOTOMETRY; ZINC;

EID: 84928975420     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424353112     Document Type: Article

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