Validation of candidate anxiety disorder genes using a carbon dioxide challenge task

Biological Psychology

Volumn 109, Issue , 2015, Pages 61-66

  Savage, Jeanne E ^a   McMichael, Omari ^a,b   Gorlin, Eugenia I ^c   Beadel, Jessica R ^c   Teachman, Bethany ^c   Vladimirov, Vladimir I ^a,b,d,e   Hettema, John M ^a,b   Roberson Nay, Roxann ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acid sensing ion channel 1; Anxiety disorders; ASIC1; Carbon dioxide hypersensitivity; Endophenotype; Panic disorder

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLECYSTOKININ B RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR 1; SEROTONIN TRANSPORTER; ACID SENSING ION CHANNEL; ASIC1 PROTEIN, HUMAN; CARBON DIOXIDE;

ADCYAP1R1 GENE; ADULT; ANXIETY DISORDER; ARTICLE; ASIC1 GENE; ASIC2 GENE; BDNF GENE; BREATHING RATE; CARBON DIOXIDE BREATHING; CCKBR GENE; COMT GENE; CONTROLLED STUDY; CRHR1 GENE; ENDOPHENOTYPE; FEMALE; FKBP5 GENE; GAD1 GENE; GENDER; GENE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN EXPERIMENT; HYPERSENSITIVITY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOLOGICAL DISTRESS ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SLC6A4 GENE; SUBJECTIVE UNITS OF DISTRESS SCALE; TMEM132D GENE; ANXIETY; CAUCASIAN; GENETICS; GENOME-WIDE ASSOCIATION STUDY; STATISTICAL MODEL; YOUNG ADULT;

ACID SENSING ION CHANNELS; ADULT; ANXIETY; ANXIETY DISORDERS; CARBON DIOXIDE; ENDOPHENOTYPES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINEAR MODELS; MALE; RESPIRATORY RATE; YOUNG ADULT;

EID: 84928941533     PISSN: 03010511     EISSN: 18736246     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2015.04.006     Document Type: Article

References (56)

1. Battaglia M., Ogliari A., Harris J., Spatola C.A., Pesenti-Gritti P., Reichborn-Kjennerud T., et al. A genetic study of the acute anxious response to carbon dioxide stimulation in man. Journal of Psychiatric Research 2007, 41(11):906-917.
2. 2 challenge test in patients with social phobia. Psychiatry Research 1997, 71(1):41-48.
3. Cardon L.R., Palmer L.J. Population stratification and spurious allelic association. Lancet 2003, 361(9357):598-604. 10.1016/S0140-6736(03)12520-2.
4. Chen Q., Tang M., Mamiya T., Im H., Xiong X., Joseph A., et al. Bi-directional effect of cholecystokin receptor-2 overexpression on stress-triggered fear memory and anxiety in the mouse. PLoS One 2010, 5(12):e15999. 10.1371/journal.pone.0015999.
5. Coryell W. Hypersensitivity to carbon dioxide as a disease-specific trait marker. Biological Psychiatry 1997, 41(3):259-263.
6. 2 as a trait of familial panic disorder. Biological Psychiatry 2001, 49(7):582-587.
7. Coryell M.W., Ziemann A.E., Westmoreland P.J., Haenfler J.M., Kurjakovic Z., Zha X., et al. Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biological Psychiatry 2007, 62(10):1140-1148.
8. Erhardt A., Akula N., Schumacher J., Czamara D., Karbalai N., Müller-Myhsok B., et al. Replication and meta-analysis of TMEM132D gene variants in panic disorder. Translational Psychiatry 2012, 2(9):e156. 10.1038/tp.2012.85.
9. Fani N., Gutman D., Tone B., Almli L., Mercer K.B., Davis J., et al. FKBP5 and attention bias for threat. JAMA Psychiatry 2013, 70(4):392-400. 10.1001/2013.jamapsychiatry.210.
10. Frustaci A., Pozzi G., Gianfagna F., Manzoli L., Boccia S. Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. Neuropsychobiology 2008, 58(3-4):163-170. 10.1159/000182892.
11. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry 2003, 160(4):636-645. 10.1176/appi.ajp.160.4.636.
12. Gregersen N., Dahl H.A., Buttenschøn H.N., Nyegaard M., Hedemand A., Als T.D., et al. A genome-wide study of panic disorder suggests the amillioride-sensitive cation channel 1 as a candidate gene. European Journal of Human Genetics 2012, 20(1):84-90. 10.1038/ejhg.2011.148.
13. Griez E., de Loof C., Pols H., Zandbergen J., Lousberg H. Specific sensitivity of patients with panic attacks to carbon dioxide inhalation?. Psychiatry Research 1990, 31(2):193-199.
14. Gyawali S., Subaran R., Wissman M.M., Hershkowitz D., McKenna M.C., Talari A., et al. Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. Biological Psychiatry 2010, 67(4):331-338. 10.1016/j.biopsych.2009.10.015.
15. Han B., Eskin E. Multiple testing in genetic epidemiology. Encyclopedia of life sciences (ELS) 2010, John Wiley & Sons, Ltd., Chichester.
16. Hartley C.A., McKenna M.C., Salman R., Holmes A., Casey B.J., Phelps E.A., et al. Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(14):5493-5498. 10.1073/pnas.1202044109.
17. Heitland I., Groenink L., Bijlsma E.Y., Oosting R.S., Baas J.M.P. Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter. PLOS ONE 2013, 8(5):e63772. 10.1371/journal.pone.0063772.
18. Hettema J.M., An S.S., Bukszar J., van den Oord E.J.C.G., Neale M.C., Kendler K.S., et al. COMT contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biological Psychiatry 2008, 64(4):302-310. 10.1016/j.biopsych.2008.03.014.
19. Hettema J.M., An S.S., Neale M.C., Bukszar J., van den Oord E.J.C.G., Kendler K.S., et al. Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Molecular Psychiatry 2006, 11:752-762. 10.1038/sj.mp.4001845.
20. Hettema J.M., Neale M.C., Myers J.M., Prescott C.A., Kendler K.S. A population-based twin study of the relationship between neuroticism and internalizing disorders. American Journal of Psychiatry 2006, 163(5):857-864. 10.1176/appi.ajp.163.5.857.
21. Jovanovic T., Norrholm S.D., Davis J., Mercer K.B., Almli L., Nelson A., et al. PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children. Molecular Psychiatry 2013, 18(7):742-743. 10.1038/mp.2012.98.
22. Keck M.E., Kern N., Erhardt A., Unschuld P.G., Ising M., Salyakina D., et al. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in case/control study for panic disorder. American Journal of Medical Genetics B: Neuropsychiatric Genetics 2008, 147B(7):1196-1204. 10.1002/ajmg.b.30750.
23. Kennedy J.L., Bradwejn J., Koszycki D., King N., Crowe R., Vincent J., et al. Investigation of cholecystokinin system genes in panic disorder. Molecular Psychiatry 1999, 4:284-285.
24. Li J., Ji L. Adjusting multiple testing in multilocus analyses using the Eigenvalues of a correlation matrix. Heredity 2005, 95:221-227.
25. Lonsdorf T.B., Kalisch R. A review on experimental and clinical genetic associations studies on fear conditioning, extinction, and cognitive-behavioral treatment. Translational Psychiatry 2011, 1(9):e41. 10.1038/tp.2011.36.
26. Lonsdorf T.B., Weike A.I., Nikamo P., Schalling M., Hamm A.O., Ohman A. Genetic gating of human fear learning and extinction: Possible implications for gene-environment interaction in anxiety disorder. Psychological Science 2009, 20(2):198-206. 10.1111/j.1467-9280.2009.02280.x.
27. Maddock R.J. The lactic acid response to alkalosis in panic disorder: An integrative review. Journal of Neuropsychiatry and Clinical Neurosciences 2001, 13:22-34.
28. Maron E., Hettema J.M., Shlik J. Advances in molecular genetics of panic disorder. Molecular Psychiatry 2010, 15:681-701. 10.1038/mp.2009.145.
29. Meyer-Lindenberg A., Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience 2006, 7:818-827.
30. Middledorp C.M., Slof-Op't Landt M.C.T., Medland S.E., van Beijsterveldt C.E.M., Bartels M., Willemsen G., et al. Anxiety and depression in children and adults: Influence of serotonergic and neurotrophic genes?. Genes Brain Behavior 2010, 9(7):808-816. 10.1111/j.1601-183X.2010.00619.x.
31. Muthén L.K., Muthén B.O. Mplus user's guide 2010, Muthén & Muthén, Los Angeles, CA. 6th ed.
32. Nyholt D.R. A simple correction for multiple testing for SNPs in linkage disequilibrium with each other. American Journal of Human Genetics 2004, 74(4):765-769.
33. 2 challenge in panic and mood disorders. Journal of Affective Disorders 1995, 33(3):189-194.
34. Price M.P., Gong H., Parsons M.G., Kundert J.R., Reznikov L.R., Bernardinelle L., et al. Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes Brain Behavior 2014, 13(2):179-194. 10.1111/gbb.12108.
35. Rassovsky Y., Kushner M.G. Carbon dioxide in the study of panic disorder: Issues of definition, methodology, and outcome. Journal of Anxiety Disorders 2003, 17(1):1-32.
36. Reiss S., Peterson R.A., Gursky D.M., McNally R.J. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behavior Research and Therapy 1986, 24(1):1-8.
37. Ressler K.J., Mercer K.B., Bradley B., Jovanovic T., Mahan A., Kerley K., et al. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 2011, 470(7335):492-497. 10.1038/nature09856.
38. Rothe C., Koszycki D., Bradweijn J., King N., Deluca V., Tharmalingam S., et al. Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder. Neuropsychopharmacology 2006, 31(10):2237-2242. 10.1038/sj.npp.1301048.
39. Sanderson W.C., Rapee R.M., Barlow D.H. The influence of an illusion of control on panic attacks induced via inhalation of 5.5% carbon dioxide-enriched air. Archives of General Psychiatry 1989, 46(2):157-162.
40. 2 challenge reactivity as unique and interactive prospective predictors of anxiety pathology. Depression and Anxiety 2007, 24(8):527-536.
41. Singh L., Lewis A.S., Field M.J., Hughes J., Woodruff G.N. Evidence for an involvement of the brain cholecystokinin B receptor in anxiety. Proceedings of the National Academy of Sciences of the United States of America 1991, 88(4):1130-1133.
42. Smoller J.W., Gallagher P.J., Duncan L.E., McGrath L.M., Haddad S.A., Holmes A.J., et al. The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function. Biological Psychiatry 2014, ePub ahead of print. 10.1016/j.biopsych.2013.12.018.
43. Smoller J.W., Tsuang M.T. Panic and phobic anxiety: Defining phenotypes for genetic studies. American Journal of Psychiatry 1998, 155:1152-1162.
44. Snieder H., Boomsma D.I., Van Doornen L.J., De Geus E.J.C. Heritability of respiratory sinus arrhythmia: Dependency on task and respiration rate. Psychophysiology 1997, 34:317-328.
45. Soliman F., Glatt C.E., Bath K.G., Levita L., Jones R.M., Pattwell S.S., et al. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 2010, 327(5967):863-866. 10.1126/science.1181886.
46. Song N., Zhang G., Geng W., Liu W., Liu Z., Jin W., et al. Acid sensing ion channel 1 in lateral hypothalamus contributes to breathing control. PLoS One 2012, 7(7):e39982. 10.1371/journal.pone.0039982.
47. Strug L.J., Suresh R., Fyer A.J., Talati A., Adams P.B., Li W., et al. Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Molecular Psychiatry 2010, 15(2):166-176. 10.1038/mp.2008.79.
48. Telch M.J., Rosenfield D., Pai A. Emotional reactivity to a single inhalation of 35% carbon dioxide and its association with later symptoms of posttraumatic stress disorder and anxiety in soldiers deployed to Iraq. Archives of General Psychiatry 2012, 69(11):1161-1168. 10.1001/archgenpsychiatry.2012.8.
49. Vickers K., Jafarpour S., Mofidi A., Rafat B., Woznica A. The 35% carbon dioxide test in stress and panic research: Overview of effects and integration of findings. Clinical Psychology Review 2012, 32(3):153-164. 10.1016/j.cpr.2011.12.004.
50. Weber H., Scholz C.J., Domschke K., Baumann C., Klauke B., Jacob C.P. Gender differences in associations of Glutamate Decarboxylase 1 gene (GAD1) variants with panic disorder. PLoS One 2012, 7(5):e37651. 10.1371/journal.pone.0037651.
51. Wemmie J.A. Neurobiology of panic and pH chemosensation in the brain. Dialogues in Clinical Neurosciences 2011, 13(4):475-483.
52. Wemmie J.A., Coryell M.W., Askwith C.C., Lamani E., Leonard A.S., Sigmund C.D., et al. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proceedings of the National Academy of Sciences of the United States of America 2004, 101(10):3621-3626. 10.1073/pnas.0308753101.
53. White M.G., Bogdan R., Fisher P.M., Muñoz K., Williamson D.E., Hariri A.R. FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. Genes Brain Behavior 2012, 11(7):869-878. 10.1111/j.1601-183X.2012.00837.x.
54. Wolpe J. The practice of behavior therapy 1973, Pergamon Press Inc., Elmsford, NY.
55. Wray N.R., James M.R., Gordon S.D., Dumenil T., Ryan L., Coventry W.L., et al. Accurate, large-scale genotyping of 5HTTLPR and flanking SNPs in an association study of depression, anxiety, and personality measures. Biological Psychiatry 2009, 66(5):468-476. 10.1016/j.biopsych.2009.04.030.
56. Ziemann A.E., Allen J.E., Dahdeleh N.S., Drebot I.I., Coryell M., Wunsch A.M., et al. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 2009, 139(5):1012-1021. 10.1016/j.cell.2009.10.029.