Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Weber, Heike ^a   Scholz, Claus Jürgen ^a   Domschke, Katharina ^a,b   Baumann, Christian ^a   Klauke, Benedikt ^b   Jacob, Christian P ^a   Maier, Wolfgang ^c   Fritze, Jürgen ^d   Bandelow, Borwin ^e   Zwanzger, Peter Michael ^b   Lang, Thomas ^f,g   Fehm, Lydia ^h   Ströhle, Andreas ⁱ   Hamm, Alfons ^j   Gerlach, Alexander L ^k   Alpers, Georg W ^a,l   Kircher, Tilo ^m   Wittchen, Hans Ulrich ⁿ   Arolt, Volker ^a   Pauli, Paul ^a   Deckert, Jürgen ^a   Reif, Andreas ^a   more..

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

^f Christoph Dornier Foundation for Clinical Psychology   (Germany)

^g UNIVERSITY OF BREMEN   (Germany)

^h HUMBOLDT UNIVERSITY   (Germany)

ⁱ CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^j UNIVERSITY OF GREIFSWALD   (Germany)

^k UNIVERSITY OF COLOGNE   (Germany)

^l UNIVERSITY OF MANNHEIM   (Germany)

^m PHILIPPS UNIVERSITY MARBURG   (Germany)

ⁿ DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GAD1 GENE; GENE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PANIC; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTAMATE DECARBOXYLASE; HUMANS; MALE; MIDDLE AGED; PANIC DISORDER; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 84861477335     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037651     Document Type: Article

References (49)

1. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, et al. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62: 593-602.
2. Bekker MH, van Mens-Verhulst J, (2007) Anxiety disorders: sex differences in prevalence, degree, and background, but gender-neutral treatment. Gend Med 4 (Suppl B): S178-193.
3. Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS, (2006) A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 163: 857-864.
4. Middeldorp CM, Cath DC, Van Dyck R, Boomsma DI, (2005) The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychol Med 35: 611-624.
5. Zwanzger P, Rupprecht R, (2005) Selective GABAergic treatment for panic? Investigations in experimental panic induction and panic disorder. J Psychiatry Neurosci 30: 167-175.
6. Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, et al. (2001) Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch Gen Psychiatry 58: 556-561.
7. Ham BJ, Sung Y, Kim N, Kim SJ, Kim JE, et al. (2007) Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study. Prog Neuropsychopharmacol Biol Psychiatry 31: 403-411.
8. Cherlyn SY, Woon PS, Liu JJ, Ong WY, Tsai GC, et al. (2010) Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci Biobehav Rev 34: 958-977.
9. McCarthy MM, Kaufman LC, Brooks PJ, Pfaff DW, Schwartz-Giblin S, (1995) Estrogen modulation of mRNA levels for the two forms of glutamic acid decarboxylase (GAD) in female rat brain. J Comp Neurol 360: 685-697.
10. Noriega NC, Eghlidi DH, Garyfallou VT, Kohama SG, Kryger SG, et al. (2010) Influence of 17beta-estradiol and progesterone on GABAergic gene expression in the arcuate nucleus, amygdala and hippocampus of the rhesus macaque. Brain Res 1307: 28-42.
11. Fyer AJ, Hamilton SP, Durner M, Haghighi F, Heiman GA, et al. (2006) A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. Biol Psychiatry 60: 388-401.
12. Hettema JM, An SS, Neale MC, Bukszar J, van den Oord EJ, et al. (2006) Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Mol Psychiatry 11: 752-762.
13. Geller B, Tillman R, Bolhofner K, Hennessy K, Cook EH Jr, (2008) GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype. J Child Adolesc Psychopharmacol 18: 25-29.
14. Lundorf MD, Buttenschon HN, Foldager L, Blackwood DH, Muir WJ, et al. (2005) Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 135B: 94-101.
15. Addington AM, Gornick M, Duckworth J, Sporn A, Gogtay N, et al. (2005) GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss. Mol Psychiatry 10: 581-588.
16. Du J, Duan S, Wang H, Chen W, Zhao X, et al. (2008) Comprehensive analysis of polymorphisms throughout GAD1 gene: a family-based association study in schizophrenia. J Neural Transm 115: 513-519.
17. Straub RE, Lipska BK, Egan MF, Goldberg TE, Callicott JH, et al. (2007) Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression. Mol Psychiatry 12: 854-869.
18. Zhao X, Qin S, Shi Y, Zhang A, Zhang J, et al. (2007) Systematic study of association of four GABAergic genes: glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABA(B) receptor 1 gene and GABA(A) receptor subunit beta2 gene, with schizophrenia using a universal DNA microarray. Schizophr Res 93: 374-384.
19. Utge S, Soronen P, Partonen T, Loukola A, Kronholm E, et al. (2010) A population-based association study of candidate genes for depression and sleep disturbance. Am J Med Genet B Neuropsychiatr Genet 153B: 468-476.
20. Chambless DL, Caputo GC, Bright P, Gallagher R, (1984) Assessment of fear of fear in agoraphobics: the body sensations questionnaire and the agoraphobic cognitions questionnaire. J Consult Clin Psychol 52: 1090-1097.
21. Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, et al. (2004) Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 61: 705-713.
22. Jarius S, Stich O, Speck J, Rasiah C, Wildemann B, et al. (2010) Qualitative and quantitative evidence of anti-glutamic acid decarboxylase-specific intrathecal antibody synthesis in patients with stiff person syndrome. J Neuroimmunol.
23. Koerner C, Wieland B, Richter W, Meinck HM, (2004) Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity. Neurology 62: 1357-1362.
24. Geis C, Weishaupt A, Grunewald B, Wultsch T, Reif A, et al. (2011) Human stiff-person syndrome IgG induces anxious behavior in rats. PLoS One 6: e16775.
25. Donner J, Sipila T, Ripatti S, Kananen L, Chen X, et al. (2012) Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. Am J Med Genet B Neuropsychiatr Genet 159B: 316-327.
26. Marenco S, Savostyanova AA, van der Veen JW, Geramita M, Stern A, et al. (2010) Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT. Neuropsychopharmacology 35: 1708-1717.
27. Yoon JH, Maddock RJ, Rokem A, Silver MA, Minzenberg MJ, et al. (2010) GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. J Neurosci 30: 3777-3781.
28. Lappalainen J, Sanacora G, Kranzler HR, Malison R, Hibbard ES, et al. (2004) Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression. Am J Med Genet B Neuropsychiatr Genet 124B: 81-86.
29. Ikeda M, Ozaki N, Yamanouchi Y, Suzuki T, Kitajima T, et al. (2007) No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. Schizophr Res 91: 22-26.
30. Buttenschon HN, Lauritsen MB, El Daoud A, Hollegaard M, Jorgensen M, et al. (2009) A population-based association study of glutamate decarboxylase 1 as a candidate gene for autism. J Neural Transm 116: 381-388.
31. Rabionet R, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS, et al. (2004) Analysis of the autism chromosome 2 linkage region: GAD1 and other candidate genes. Neurosci Lett 372: 209-214.
32. Mosing MA, Gordon SD, Medland SE, Statham DJ, Nelson EC, et al. (2009) Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin study. Depress Anxiety 26: 1004-1011.
33. Smoller JW, Block SR, Young MM, (2009) Genetics of anxiety disorders: the complex road from DSM to DNA. Depress Anxiety 26: 965-975.
34. Klauke B, Deckert J, Reif A, Pauli P, Domschke K, (2010) Life events in panic disorder-an update on "candidate stressors". Depress Anxiety.
35. Zhang TY, Hellstrom IC, Bagot RC, Wen X, Diorio J, et al. (2010) Maternal care and DNA methylation of a glutamic Acid decarboxylase 1 promoter in rat hippocampus. J Neurosci 30: 13130-13137.
36. Mannuzza S, Fyer AJ, Klein DF, Endicott J, (1986) Schedule for Affective Disorders and Schizophrenia-Lifetime Version modified for the study of anxiety disorders (SADS-LA): rationale and conceptual development. J Psychiatr Res 20: 317-325.
37. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, et al. (1988) The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 45: 1069-1077.
38. Wittchen HU, (1997) SKID-I: Strukturiertes Klinisches Interview für DSM-IV, Achse I: Psychische Störungen Goettingen Hogrefe.
39. Gloster AT, Wittchen HU, Einsle F, Hofler M, Lang T, et al. (2009) Mechanism of action in CBT (MAC): methods of a multi-center randomized controlled trial in 369 patients with panic disorder and agoraphobia. Eur Arch Psychiatry Clin Neurosci 259 (Suppl 2): S155-166.
40. Reiss S, Peterson RA, Gursky DM, McNally RJ, (1986) Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther 24: 1-8.
41. Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, et al. (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449: 851-861.
42. Barrett JC, Fry B, Maller J, Daly MJ, (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
43. Menashe I, Rosenberg PS, Chen BE, (2008) PGA: power calculator for case-control genetic association analyses. BMC Genet 9: 36.
44. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
45. R Development Core Team (2010) R: A Language and Environment for Statistical Computing. 2.11 ed. Vienna, Austria.
46. Coassin S, Brandstatter A, Kronenberg F, (2010) Lost in the space of bioinformatic tools: a constantly updated survival guide for genetic epidemiology. The GenEpi Toolbox. Atherosclerosis 209: 321-335.
47. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, et al. (2005) MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21: 2933-2942.
48. Lee PH, Shatkay H, (2008) F-SNP: computationally predicted functional SNPs for disease association studies. Nucleic Acids Res 36: D820-824.
49. Lee PH, Shatkay H, (2009) An integrative scoring system for ranking SNPs by their potential deleterious effects. Bioinformatics 25: 1048-1055.