Baicalin-induced Akt activation decreases melanogenesis through downregulation of microphthalmia-associated transcription factor and tyrosinase

European Journal of Pharmacology

Volumn 761, Issue , 2015, Pages 19-27

  Jeong, Hyo Soon ^a   Gu, Go Eun ^a   Jo, Ah Reum ^a   Bang, Joon Seok ^b   Yun, Hye Young ^a   Baek, Kwang Jin ^a   Kwon, Nyoun Soo ^a   Park, Kyoung Chan ^c   Kim, Dong Seok ^a  

^a Chung Ang University College of Medicine   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

Author keywords

Akt; Baicalin; Melanocytes; MITF; Tyrosinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BAICALIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MELANIN; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOPHENOL MONOOXYGENASE; PROTEIN KINASE B; FLAVONOID; MITF PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; HYPOPIGMENTATION; MELANOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; MELANOCYTE; METABOLISM; TIME FACTOR;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; FLAVONOIDS; MELANINS; MELANOCYTES; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MONOPHENOL MONOOXYGENASE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84928897525     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.04.028     Document Type: Article

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