The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue

Experimental Dermatology

Volumn 20, Issue 3, 2011, Pages 237-241

  Lee, Ju Eun ^a   Kim, Su Yeon ^a   Jeong, Yun Mi ^a   Yun, Hye Young ^a   Baek, Kwang Jin ^a   Kwon, Nyoun Soo ^a   Park, Kyoung Chan ^b   Kim, Dong Seok ^a  

^a Chung Ang University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

catenin; FTY720; Melanogenesis; MITF

Indexed keywords

BETA CATENIN; FINGOLIMOD; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOPHENOL MONOOXYGENASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; MELANOCYTE; MELANOGENESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BETA CATENIN; CELL LINE, TRANSFORMED; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; GLYCOGEN SYNTHASE KINASE 3; INDOLES; MALEIMIDES; MELANINS; MELANOCYTES; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MONOPHENOL MONOOXYGENASE; PHOSPHORYLATION; PROPYLENE GLYCOLS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 79951649767     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2010.01148.x     Document Type: Article

References (25)

1. Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol 2004: 15: 513-520.
2. Lee J F, Zeng Q, Ozaki H et al. Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. J Biol Chem 2006: 281: 29190-29200.
3. McVerry B J, Garcia J G. In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal 2005: 17: 131-139.
4. Kim D S, Hwang E S, Lee J E et al. Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. J Cell Sci 2003: 116: 1699-1706.
5. Fujita T, Inoue K, Yamamoto S et al. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) 1994: 47: 208-215.
6. Adachi K, Chiba K. FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology. Perspect Medicin Chem 2008: 1: 11-23.
7. Ando H, Kondoh H, Ichihashi M et al. Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase. J Invest Dermatol 2007: 127: 751-761.
8. Slominski A, Tobin D J, Shibahara S et al. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 2004: 84: 1155-1228.
9. Schallreuter K U, Hasse S, Rokos H et al. Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells. Exp Dermatol 2009: 18: 680-688.
10. Costin G E, Hearing V J. Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J 2007: 21: 976-994.
11. Levy C, Khaled M, Fisher D E. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 2006: 12: 406-414.
12. Villareal M O, Han J, Yamada P et al. Hirseins inhibit melanogenesis by regulating the gene expressions of Mitf and melanogenesis enzymes. Exp Dermatol 2010: 19: 450-457.
13. Aberdam E, Bertolotto C, Sviderskaya E V et al. Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein. J Biol Chem 1998: 273: 19560-19565.
14. Larue L, Delmas V. The WNT/beta-catenin pathway in melanoma. Front Biosci 2006: 11: 733-742.
15. Wu J, Saint-Jeannet J P, Klein P S. Wnt-frizzled signaling in neural crest formation. Trends Neurosci 2003: 26: 40-45.
16. Bellei B, Flori E, Izzo E et al. GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes. Cell Signal 2008: 20: 1750-1761.
17. Dooley T P, Gadwood R C, Kilgore K et al. Development of an in vitro primary screen for skin depigmentation and antimelanoma agents. Skin Pharmacol 1994: 7: 188-200.
18. Tsuboi T, Kondoh H, Hiratsuka J et al. Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. Pigment Cell Res 1998: 11: 275-282.
19. Khaled M, Larribere L, Bille K et al. Glycogen synthase kinase 3beta is activated by cAMP and plays an active role in the regulation of melanogenesis. J Biol Chem 2002: 277: 33690-33697.
20. Kim D S, Park S H, Kwon S B et al. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. Pigment Cell Res 2006: 19: 146-153.
21. Yanase H, Ando H, Horikawa M et al. Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes. Pigment Cell Res 2001: 14: 103-109.
22. Haraguchi K, Ohsugi M, Abe Y et al. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Oncogene 2008: 27: 274-284.
23. Latres E, Chiaur D S, Pagano M. The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene 1999: 18: 849-854.
24. Aberle H, Bauer A, Stappert J et al. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997: 16: 3797-3804.
25. Takeda K, Yasumoto K, Takada R et al. Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a. J Biol Chem 2000: 275: 14013-14016.