Fisetin inhibits listeria monocytogenes virulence by interfering with the oligomerization of listeriolysin O

Journal of Infectious Diseases

Volumn 211, Issue 9, 2015, Pages 1376-1387

  Wang, Jianfeng ^a   Qiu, Jiazhang ^a   Tan, Wei ^a   Zhang, Yu ^a   Wang, Hongshu ^a   Zhou, Xuan ^a   Liu, Shui ^a   Feng, Haihua ^a   Li, Wenhua ^a   Niu, Xiaodi ^b   Deng, Xuming ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

Anti virulence; Infection; Molecular modeling; Toxin

Indexed keywords

FISETIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LISTERIOLYSIN O; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL TOXIN; FLAVONOID; HEAT SHOCK PROTEIN; HEMOLYSIN; HLYA PROTEIN, LISTERIA MONOCYTOGENES;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIAL REPRODUCTION; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; HEMOLYSIS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OLIGOMERIZATION; PHAGOSOME; PRIORITY JOURNAL; SINGLE DRUG DOSE; SURVIVAL TIME; TISSUE CULTURE; ANIMAL; BAGG ALBINO MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOGENICITY; VIRULENCE;

ANIMALS; BACTERIAL TOXINS; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION, BACTERIAL; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; LISTERIA MONOCYTOGENES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR STRUCTURE; VIRULENCE;

EID: 84928881614     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu520     Document Type: Article

References (35)

1. Cossart P. Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes. Proc Natl Acad Sci USA 2011; 108:19484-91.
2. Allerberger F, Wagner M. Listeriosis: a resurgent foodborne infection. Clin Microbiol Infect 2010; 16:16-23.
3. Posfay-Barbe KM, Wald ER. Listeriosis. Semin Fetal Neonatal Med 2009; 14:228-33.
4. Williams MA, Schmidt RL, Lenz LL. Early events regulating immunity and pathogenesis during Listeria monocytogenes infection. Trends Immunol 2012; 33:488-95.
5. Vazquez-Boland JA, Kuhn M, Berche P, et al. Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev 2001; 14:584-640.
6. Schnupf P, Portnoy DA. Listeriolysin O: a phagosome-specific lysin. Microbes Infect 2007; 9:1176-87.
7. Lety MA, Frehel C, Berche P, Charbit A. Critical role of the N-terminal residues of listeriolysin O in phagosomal escape and virulence of Liste-ria monocytogenes. Mol Microbiol 2002; 46:367-79.
8. Cossart P, Vicente MF, Mengaud J, Baquero F, Perez-Diaz JC, Berche P. Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation. Infect Immun 1989; 57:3629-36.
9. Lee KD, Oh YK, Portnoy DA, Swanson JA. Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria mono-cytogenes. J Biol Chem 1996; 271:7249-52.
10. Bielecki J, Youngman P, Connelly P, Portnoy DA. Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells. Nature 1990; 345:175-6.
11. Kayal S, Charbit A. Listeriolysin O: a key protein of Listeria mono-cytogenes with multiple functions. FEMS Microbiol Rev 2006; 30: 514-29.
12. Hamon MA, Ribet D, Stavru F, Cossart P. Listeriolysin O: the Swiss army knife of Listeria. Trends Microbiol 2012; 20:360-8.
13. Rasko DA, Sperandio V. Anti-virulence strategies to combat bacteria-mediated disease. Nat Rev Drug Discov 2010; 9:117-28.
14. Adhami VM, Syed DN, Khan N, Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol 2012; 84:1277-81.
15. Liu D. Identification, subtyping and virulence determination of Listeria monocytogenes, an important foodborne pathogen. J Med Microbiol 2006; 55:645-59.
16. Hara H, Tsuchiya K, Nomura T, Kawamura I, Shoma S, Mitsuyama M. Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phago-some into the cytoplasm. J Immunol 2008; 180:7859-68.
17. Kastbjerg VG, Larsen MH, Gram L, Ingmer H. Influence of sublethal concentrations of common disinfectants on expression of virulence genes in Listeria monocytogenes. Appl Environ Microbiol 2010; 76:303-9.
18. Smith-Palmer A, Stewartt J, Fyfe L. Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils. J Med Microbiol 2002; 51:567-74.
19. Bavdek A, Gekara NO, Priselac D, et al. Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O. Biochemistry 2007; 46:4425-37.
20. Grundling A, Gonzalez MD, Higgins DE. Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during infection of human epithelial cells. J Bacteriol 2003; 185:6295-307.
21. Tilney LG, Portnoy DA. Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocyto-genes. J Cell Biol 1989; 109:1597-608.
22. Schaffner-Barbero C, Gil-Redondo R, Ruiz-Avila LB, et al. Insights into nucleotide recognition by cell division protein FtsZ from a mant-GTP competition assay and molecular dynamics. Biochemistry 2010; 49:10458-72.
23. Punkvang A, Saparpakorn P, Hannongbua S, Wolschann P, Beyer A, Pungpo P. Investigating the structural basis of arylamides to improve potency against M. tuberculosis strain through molecular dynamics simulations. Eur J Med Chem 2010; 45:5585-93.
24. Hu Y-J, Liu Y, Zhang L-X, Zhao R-M, Qu S-S. Studies of interaction between colchicine and bovine serum albumin by fluorescence quenching method. J Mol Struct 2005; 750:174-8.
25. Giddings KS, Johnson AE, Tweten RK. Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins. Proc Natl Acad Sci USA 2003; 100:11315-20.
26. Jacobs T, Darji A, Frahm N, et al. Listeriolysin O: cholesterol inhibits cytolysis but not binding to cellular membranes. Mol Microbiol 1998; 28:1081-9.
27. Kohda C, Yanagawa Y, Shimamura T. Epigallocatechin gallate inhibits intracellular survival of Listeria monocytogenes in macrophages. Bio-chem Biophys Res Commun 2008; 365:310-5.
28. Cellmer T, Buscaglia M, Henry ER, Hofrichter J, Eaton WA. Making connections between ultrafast protein folding kinetics and molecular dynamics simulations. Proc Natl Acad Sci USA 2011; 108:6103-8.
29. Webber MJ, Spivey AC. Molecular modelling: Supporting Saytzeff. Nat Chem 2009; 1:435-6.
30. Vargiu AV, Collu F, Schulz R, et al. Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations. J Am Chem Soc 2011; 133: 10704-7.
31. Olausson BE, Grossfield A, Pitman MC, Brown MF, Feller SE, Vogel A. Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes. J Am Chem Soc 2012; 134:4324-31.
32. Duclert-Savatier N, Poggi L, Miclet E, et al. Insights Into the Enzymatic Mechanism of 6-Phosphogluconolactonase from Trypanosoma brucei Using Structural Data and Molecular Dynamics Simulation. J Mol Biol 2009; 388:1009-21.
33. Perryman AL, Forli S, Morris GM, et al. A dynamic model of HIV integrase inhibition and drug resistance. J Mol Biol 2010; 397: 600-15.
34. Ragle BE, Bubeck Wardenburg J. Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia. Infect Immun 2009; 77:2712-8.
35. Edelson BT, Unanue ER. Intracellular antibody neutralizes Listeria growth. Immunity 2001; 14:503-12.