Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate

Nature Communications

Volumn 6, Issue , 2015, Pages

  Hiraoka, Kiriko ^a   Inoue, Takahiro ^a   Taylor, Rhys Dylan ^b   Watanabe, Takayoshi ^a   Koshikawa, Nobuko ^a   Yoda, Hiroyuki ^a   Shinohara, Ken Ichi ^a   Takatori, Atsushi ^a   Sugimoto, Hirokazu ^a   Maru, Yoshiaki ^a   Denda, Tadamichi ^a   Fujiwara, Kyoko ^c   Balmain, Allan ^d   Ozaki, Toshinori ^a   Bando, Toshikazu ^b   Sugiyama, Hiroshi ^b   Nagase, Hiroki ^a  

^a CHIBA CANCER CENTER   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; K RAS PROTEIN; PYRROLE IMIDAZOLE POLYAMIDE INDOLE SECO 1,2,9,9A TETRAHYDROCYCLOPROPA[1,2 C]BENZ[1,2 E]INDOLE 4 ONE CONJUGATE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; IMIDAZOLE DERIVATIVE; KR12 COMPOUND; KRAS PROTEIN, HUMAN; NYLON; PROTEIN P21;

APOPTOSIS; CYTOLOGY; DNA; INHIBITION; MUTATION; TUMOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL AGING; CODON; CONTROLLED STUDY; DNA DAMAGE; GENE MUTATION; GENE SEQUENCE; GROWTH INHIBITION; HUMAN; HUMAN CELL; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; CACO 2 CELL LINE; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENETICS; HT 29 CELL LINE; MUTATION; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CACO-2 CELLS; CELL AGING; DNA DAMAGE; DRUG EVALUATION, PRECLINICAL; FEMALE; HT29 CELLS; HUMANS; IMIDAZOLES; MICE, NUDE; MUTATION; NEOPLASMS, EXPERIMENTAL; NYLONS; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 84928815898     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7706     Document Type: Article

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