Conjugating an anticancer drug onto thiolated hyaluronic acid by acid liable hydrazone linkage for its gelation and dual stimuli-response release

Carbohydrate Polymers

Volumn 128, Issue , 2015, Pages 163-170

  Fu, Chaoping ^a   Li, Hailiang ^b   Li, Nannan ^a   Miao, Xiangwan ^b   Xie, Minqiang ^b   Du, Wenjun ^c   Zhang, Li Ming ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

Cancer cell inhibition; Chemical conjugation; Doxorubicin hydrochloride; Gelation Stimuli responsive release; Thiolated hyaluronic acid

Indexed keywords

CELLS; CHEMICAL ANALYSIS; CYTOLOGY; DISEASES; GELATION; HYDROGELS; ORGANIC ACIDS;

ANTICANCER DRUG; CANCER CELLS; DOXORUBICIN HYDROCHLORIDE; ELASTIC RESPONSE; NASOPHARYNGEAL CARCINOMA; RELEASE MEDIA; STIMULI-RESPONSIVE; THIXOTROPIC PROPERTIES;

HYALURONIC ACID;

ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; DOXORUBICIN; HYALURONIC ACID; HYDRAZONE DERIVATIVE; HYDROGEL; THIOL DERIVATIVE;

ADMINISTRATION AND DOSAGE; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG RELEASE; HUMAN; HYDROGEL; PH; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG LIBERATION; HUMANS; HYALURONIC ACID; HYDRAZONES; HYDROGELS; HYDROGEN-ION CONCENTRATION; SULFHYDRYL COMPOUNDS;

EID: 84928812499     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2015.04.024     Document Type: Article

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